Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery Article Swipe
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Vesa Cheng
,
Jessica Suna
,
Xin Liu
,
Gregory Moloney
,
Supreet P Marathe
,
Suzanne L. Parker
,
Jacobus Ungerer
,
Brett McWhinney
,
Prem Venugopal
,
Nelson Alphonso
,
Jason A. Roberts
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.accpm.2025.101653
· OA: W4415679083
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.accpm.2025.101653
· OA: W4415679083
Postoperative cefazolin concentrations in paediatric patients undergoing cardiopulmonary bypass are often inadequate to maintain optimal antimicrobial prophylaxis. More frequent postoperative dosing or the use of extended and continuous infusion strategies can ensure effective target attainment, potentially reducing the risk of surgical site infections in this vulnerable population.
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