Porphyromonas gingivalis affects neutrophil pro-inflammatory activities Article Swipe
Agnieszka Zimny
,
Alicja Płonczyńska
,
Witold Jakubowski
,
Natalia Zubrzycka
,
Jan Potempa
,
Maja Sochalska
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2025.1419651
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcell.2025.1419651
Porphyromonas gingivalis is the primary pathogen responsible for the development of periodontal inflammatory disease. Although gingipains are the major virulence factor of the pathogen, their role in impairing apoptosis and immune cell function is not fully understood. To investigate the impact of gingipains on neutrophil viability and function, we conducted studies using murine HoxB8 neutrophils and primary human neutrophils infected with wild-type strains of Porphyromonas gingivalis (W83 and ATCC 33277), or a gingipains-null mutant with deleted gingipains encoding genes, or wild-type bacteria preincubated with specific gingipain inhibitors. Flow cytometry revealed that wild-type Porphyromonas gingivalis had a marked effect on neutrophil viability regulated by anti-apoptotic proteins belonging to the Bcl-2 family; however, these effects were independent of gingipain expression or activity. Importantly, experiments using primary human neutrophils and macrophages revealed that gingipains play a significant role in the disruption of immune cell functions via the induction of reactive oxygen species and inactivation of neutrophil elastase activity. Additionally, although gingipains played a role in modulating the IL-8-dependent inflammatory response of human neutrophils, they did not affect the expression levels of pro-inflammatory cytokines TNF-α and IL-6.
Related Topics
Concepts
Porphyromonas gingivalis
Microbiology
Periodontal pathogen
Immune system
Biology
Innate immune system
Virulence factor
Proinflammatory cytokine
Immunology
Inflammation
Chemistry
Cell biology
Virulence
Bacteria
Gene
Biochemistry
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcell.2025.1419651
- OA Status
- gold
- Cited By
- 1
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406882388
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406882388Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fcell.2025.1419651Digital Object Identifier
- Title
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Porphyromonas gingivalis affects neutrophil pro-inflammatory activitiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-28Full publication date if available
- Authors
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Agnieszka Zimny, Alicja Płonczyńska, Witold Jakubowski, Natalia Zubrzycka, Jan Potempa, Maja SochalskaList of authors in order
- Landing page
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https://doi.org/10.3389/fcell.2025.1419651Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fcell.2025.1419651Direct OA link when available
- Concepts
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Porphyromonas gingivalis, Microbiology, Periodontal pathogen, Immune system, Biology, Innate immune system, Virulence factor, Proinflammatory cytokine, Immunology, Inflammation, Chemistry, Cell biology, Virulence, Bacteria, Gene, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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