Position Statement on Antiplatelet Therapy for East Asians With Coronary Artery Disease Article Swipe
Yanjun Gong
,
Young‐Hoon Jeong
,
Tzung‐Dau Wang
,
Jack Wei Chieh Tan
,
Juying Qian
,
Hongbing Yan
,
Mark Y. Chan
,
Yundai Chen
,
Shuning Zhang
,
Zuyi Yuan
,
Tse-Min Lu
,
Jiyan Chen
,
Yujie Zhou
,
Bin Liu
,
Guosheng Fu
,
Yawei Xu
,
Lang Li
,
Sidney C. Smith
,
Junbo Ge
,
Yong Huo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jacasi.2025.04.010
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.jacasi.2025.04.010
Growing clinical evidence has indicated that East Asian patients have a lower risk for cardiovascular events but a higher risk of serious bleeding during antiplatelet therapy compared with Western populations-referred to as the "East Asian Paradox." The unique risk-benefit tradeoff observed in East Asian populations has been a topic of interest, which may be influenced by a complex interplay of genetic and environmental risk factors-such as specific atherothrombotic cardiovascular risks, helicobacter pylori infection, sites of cranial atherosclerosis, and low body weight. There exist knowledge gaps in the antiplatelet therapy among East Asian populations with coronary artery disease, such as the individualized assessment of ischemic and bleeding risk, de-escalation strategy of dual antiplatelet therapy and the compliance of long-term secondary prevention. A substantial body of positive evidence supporting de-escalation strategies of dual antiplatelet therapy comes from East Asia, possibly caused by the distinct therapeutic range of antiplatelet effects and heightened pharmacodynamic response to potent P2Y12 inhibitors observed in this population. This consensus update focuses on the latest progress and hotspot issues on antiplatelet therapy in the East Asian population with coronary artery disease and therapeutic recommendations based on the best available evidence.
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- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jacasi.2025.04.010
- OA Status
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- Cited By
- 6
- References
- 183
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4411965391Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.jacasi.2025.04.010Digital Object Identifier
- Title
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Position Statement on Antiplatelet Therapy for East Asians With Coronary Artery DiseaseWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-01Full publication date if available
- Authors
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Yanjun Gong, Young‐Hoon Jeong, Tzung‐Dau Wang, Jack Wei Chieh Tan, Juying Qian, Hongbing Yan, Mark Y. Chan, Yundai Chen, Shuning Zhang, Zuyi Yuan, Tse-Min Lu, Jiyan Chen, Yujie Zhou, Bin Liu, Guosheng Fu, Yawei Xu, Lang Li, Sidney C. Smith, Junbo Ge, Yong HuoList of authors in order
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https://doi.org/10.1016/j.jacasi.2025.04.010Publisher landing page
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.jacasi.2025.04.010Direct OA link when available
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Medicine, Coronary artery disease, East Asia, Population, Internal medicine, Intensive care medicine, Cardiology, Environmental health, China, Law, Political scienceTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 6Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | JACC: Asia |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.jacasi.2025.04.010 |
| primary_location.id | doi:10.1016/j.jacasi.2025.04.010 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210201151 |
| primary_location.source.issn | 2772-3747 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2772-3747 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | JACC Asia |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | JACC: Asia |
| primary_location.landing_page_url | https://doi.org/10.1016/j.jacasi.2025.04.010 |
| publication_date | 2025-07-01 |
| publication_year | 2025 |
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