Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunit Article Swipe
Ajna Hamidovic
,
Soojeong Cho
,
John M. Davis
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsbmb.2024.106525
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jsbmb.2024.106525
Gamma-aminobutyric acid A (GABA-A) receptors in the cells of the immune system enhance anti-inflammatory responses by regulating cytokine secretion, cytotoxic responses, and cell activation. In the CNS, the formation of GABA-A subunits into a pentameric structure has been extensively studied; however, no such study has been conducted in the immune system. The objective of the present study was to examine associations between the levels of steroid hormones and GABA-A receptor δ subunit expression in the immune system. We focused on this subunit because GABA-A receptors that contain it become significantly more sensitive to steroid hormones. We collected 80 blood samples from reproductive age women for the purpose of analyzing dehydroepiandrosterone (DHEA), 17β-estradiol, progesterone, and allopregnanolone using liquid chromatography-mass spectrometry (LC-MS). Furthermore, we extracted peripheral blood mononuclear cells (PBMCs) for determining mRNA expression levels of GABA-A receptor genes encoding the δ and ε subunits. We constructed linear mixed effect models for each GABA-A receptor subunit with all 4 steroid hormones, age, and age of menarche as predictors. Whereas DHEA was significantly associated with δ subunit expression (t-value = 2.981; p = 0.003), in line with our hypothesis, none of the steroid hormones were significantly associated with the expression of the ε subunit. Results of this study indicate that significant interactions between hormones from the steroid hormone biosynthesis pathway and GABAergic machinery from the immune cells may be utilized to expand models examining the molecular basis of inflammatory conditions.
Related Topics
Concepts
Dehydroepiandrosterone
Endocrinology
Internal medicine
Receptor
Neuroactive steroid
Immune system
Hormone
Biology
GABAA receptor
Steroid
gamma-Aminobutyric acid
Chemistry
Immunology
Medicine
Androgen
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jsbmb.2024.106525
- OA Status
- hybrid
- Cited By
- 4
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394893296
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394893296Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jsbmb.2024.106525Digital Object Identifier
- Title
-
Positive association between dehydroepiandrosterone (DHEA) and gene expression of the gamma-aminobutyric acid (GABA-A) receptor δ subunitWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-17Full publication date if available
- Authors
-
Ajna Hamidovic, Soojeong Cho, John M. DavisList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jsbmb.2024.106525Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.jsbmb.2024.106525Direct OA link when available
- Concepts
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Dehydroepiandrosterone, Endocrinology, Internal medicine, Receptor, Neuroactive steroid, Immune system, Hormone, Biology, GABAA receptor, Steroid, gamma-Aminobutyric acid, Chemistry, Immunology, Medicine, AndrogenTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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