Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution Article Swipe
Vladimir Jovanović
,
Melanie Sarfert
,
Carlos S. Reyna-Blanco
,
Henrike Indrischek
,
Dulce I. Valdivia
,
Ekaterina Shelest
,
Katja Nowick
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2021.662239
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2021.662239
Gene regulatory factors (GRFs), such as transcription factors, co-factors and histone-modifying enzymes, play many important roles in modifying gene expression in biological processes. They have also been proposed to underlie speciation and adaptation. To investigate potential contributions of GRFs to primate evolution, we analyzed GRF genes in 27 publicly available primate genomes. Genes coding for zinc finger (ZNF) proteins, especially ZNFs with a Krüppel-associated box (KRAB) domain were the most abundant TFs in all genomes. Gene numbers per TF family differed between all species. To detect signs of positive selection in GRF genes we investigated more than 3,000 human GRFs with their more than 70,000 orthologs in 26 non-human primates. We implemented two independent tests for positive selection, the branch-site-model of the PAML suite and aBSREL of the HyPhy suite, focusing on the human and great ape branch. Our workflow included rigorous procedures to reduce the number of false positives: excluding distantly similar orthologs, manual corrections of alignments, and considering only genes and sites detected by both tests for positive selection. Furthermore, we verified the candidate sites for selection by investigating their variation within human and non-human great ape population data. In order to approximately assign a date to positively selected sites in the human lineage, we analyzed archaic human genomes. Our work revealed with high confidence five GRFs that have been positively selected on the human lineage and one GRF that has been positively selected on the great ape lineage. These GRFs are scattered on different chromosomes and have been previously linked to diverse functions. For some of them a role in speciation and/or adaptation can be proposed based on the expression pattern or association with human diseases, but it seems that they all contributed independently to human evolution. Four of the positively selected GRFs are KRAB-ZNF proteins, that induce changes in target genes co-expression and/or through arms race with transposable elements. Since each positively selected GRF contains several sites with evidence for positive selection, we suggest that these GRFs participated pleiotropically to phenotypic adaptations in humans.
Related Topics
Concepts
Biology
Gene
Evolutionary biology
Genome
Genetics
Human genome
Population
Negative selection
1000 Genomes Project
False positive paradox
Selection (genetic algorithm)
Computational biology
Single-nucleotide polymorphism
Demography
Machine learning
Artificial intelligence
Sociology
Computer science
Genotype
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2021.662239
- OA Status
- gold
- Cited By
- 18
- References
- 137
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3162767103
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3162767103Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fgene.2021.662239Digital Object Identifier
- Title
-
Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human EvolutionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-17Full publication date if available
- Authors
-
Vladimir Jovanović, Melanie Sarfert, Carlos S. Reyna-Blanco, Henrike Indrischek, Dulce I. Valdivia, Ekaterina Shelest, Katja NowickList of authors in order
- Landing page
-
https://doi.org/10.3389/fgene.2021.662239Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fgene.2021.662239Direct OA link when available
- Concepts
-
Biology, Gene, Evolutionary biology, Genome, Genetics, Human genome, Population, Negative selection, 1000 Genomes Project, False positive paradox, Selection (genetic algorithm), Computational biology, Single-nucleotide polymorphism, Demography, Machine learning, Artificial intelligence, Sociology, Computer science, GenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 4, 2023: 4, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
137Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3162767103 |
|---|---|
| doi | https://doi.org/10.3389/fgene.2021.662239 |
| ids.doi | https://doi.org/10.17169/refubium-31224 |
| ids.mag | 3162767103 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34079582 |
| ids.openalex | https://openalex.org/W3162767103 |
| fwci | 1.17038913 |
| type | article |
| title | Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution |
| biblio.issue | |
| biblio.volume | 12 |
| biblio.last_page | 662239 |
| biblio.first_page | 662239 |
| topics[0].id | https://openalex.org/T10222 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Genomics and Chromatin Dynamics |
| topics[1].id | https://openalex.org/T10434 |
| topics[1].field.id | https://openalex.org/fields/11 |
| topics[1].field.display_name | Agricultural and Biological Sciences |
| topics[1].score | 0.9998000264167786 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1110 |
| topics[1].subfield.display_name | Plant Science |
| topics[1].display_name | Chromosomal and Genetic Variations |
| topics[2].id | https://openalex.org/T10521 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9976999759674072 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | RNA and protein synthesis mechanisms |
| funders[0].id | https://openalex.org/F4320320879 |
| funders[0].ror | https://ror.org/018mejw64 |
| funders[0].display_name | Deutsche Forschungsgemeinschaft |
| funders[1].id | https://openalex.org/F4320320882 |
| funders[1].ror | https://ror.org/03bsmfz84 |
| funders[1].display_name | Volkswagen Foundation |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 1972 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2126 |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7955895662307739 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C104317684 |
| concepts[1].level | 2 |
| concepts[1].score | 0.601288378238678 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[1].display_name | Gene |
| concepts[2].id | https://openalex.org/C78458016 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5815495848655701 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q840400 |
| concepts[2].display_name | Evolutionary biology |
| concepts[3].id | https://openalex.org/C141231307 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5395992994308472 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[3].display_name | Genome |
| concepts[4].id | https://openalex.org/C54355233 |
| concepts[4].level | 1 |
| concepts[4].score | 0.528801441192627 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[4].display_name | Genetics |
| concepts[5].id | https://openalex.org/C197077220 |
| concepts[5].level | 4 |
| concepts[5].score | 0.4874277412891388 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q720988 |
| concepts[5].display_name | Human genome |
| concepts[6].id | https://openalex.org/C2908647359 |
| concepts[6].level | 2 |
| concepts[6].score | 0.48562517762184143 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2625603 |
| concepts[6].display_name | Population |
| concepts[7].id | https://openalex.org/C7386963 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4821314811706543 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q3954859 |
| concepts[7].display_name | Negative selection |
| concepts[8].id | https://openalex.org/C97425143 |
| concepts[8].level | 5 |
| concepts[8].score | 0.43515199422836304 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q164786 |
| concepts[8].display_name | 1000 Genomes Project |
| concepts[9].id | https://openalex.org/C64869954 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4301193058490753 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1859747 |
| concepts[9].display_name | False positive paradox |
| concepts[10].id | https://openalex.org/C81917197 |
| concepts[10].level | 2 |
| concepts[10].score | 0.41455739736557007 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q628760 |
| concepts[10].display_name | Selection (genetic algorithm) |
| concepts[11].id | https://openalex.org/C70721500 |
| concepts[11].level | 1 |
| concepts[11].score | 0.40473902225494385 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[11].display_name | Computational biology |
| concepts[12].id | https://openalex.org/C153209595 |
| concepts[12].level | 4 |
| concepts[12].score | 0.19877952337265015 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q501128 |
| concepts[12].display_name | Single-nucleotide polymorphism |
| concepts[13].id | https://openalex.org/C149923435 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q37732 |
| concepts[13].display_name | Demography |
| concepts[14].id | https://openalex.org/C119857082 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q2539 |
| concepts[14].display_name | Machine learning |
| concepts[15].id | https://openalex.org/C154945302 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11660 |
| concepts[15].display_name | Artificial intelligence |
| concepts[16].id | https://openalex.org/C144024400 |
| concepts[16].level | 0 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q21201 |
| concepts[16].display_name | Sociology |
| concepts[17].id | https://openalex.org/C41008148 |
| concepts[17].level | 0 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[17].display_name | Computer science |
| concepts[18].id | https://openalex.org/C135763542 |
| concepts[18].level | 3 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[18].display_name | Genotype |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.7955895662307739 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/gene |
| keywords[1].score | 0.601288378238678 |
| keywords[1].display_name | Gene |
| keywords[2].id | https://openalex.org/keywords/evolutionary-biology |
| keywords[2].score | 0.5815495848655701 |
| keywords[2].display_name | Evolutionary biology |
| keywords[3].id | https://openalex.org/keywords/genome |
| keywords[3].score | 0.5395992994308472 |
| keywords[3].display_name | Genome |
| keywords[4].id | https://openalex.org/keywords/genetics |
| keywords[4].score | 0.528801441192627 |
| keywords[4].display_name | Genetics |
| keywords[5].id | https://openalex.org/keywords/human-genome |
| keywords[5].score | 0.4874277412891388 |
| keywords[5].display_name | Human genome |
| keywords[6].id | https://openalex.org/keywords/population |
| keywords[6].score | 0.48562517762184143 |
| keywords[6].display_name | Population |
| keywords[7].id | https://openalex.org/keywords/negative-selection |
| keywords[7].score | 0.4821314811706543 |
| keywords[7].display_name | Negative selection |
| keywords[8].id | https://openalex.org/keywords/1000-genomes-project |
| keywords[8].score | 0.43515199422836304 |
| keywords[8].display_name | 1000 Genomes Project |
| keywords[9].id | https://openalex.org/keywords/false-positive-paradox |
| keywords[9].score | 0.4301193058490753 |
| keywords[9].display_name | False positive paradox |
| keywords[10].id | https://openalex.org/keywords/selection |
| keywords[10].score | 0.41455739736557007 |
| keywords[10].display_name | Selection (genetic algorithm) |
| keywords[11].id | https://openalex.org/keywords/computational-biology |
| keywords[11].score | 0.40473902225494385 |
| keywords[11].display_name | Computational biology |
| keywords[12].id | https://openalex.org/keywords/single-nucleotide-polymorphism |
| keywords[12].score | 0.19877952337265015 |
| keywords[12].display_name | Single-nucleotide polymorphism |
| language | en |
| locations[0].id | doi:10.3389/fgene.2021.662239 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597340651 |
| locations[0].source.issn | 1664-8021 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-8021 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Genetics |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Genetics |
| locations[0].landing_page_url | https://doi.org/10.3389/fgene.2021.662239 |
| locations[1].id | pmid:34079582 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in genetics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34079582 |
| locations[2].id | pmh:oai:refubium.fu-berlin.de:fub188/31492 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306402444 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Refubium (Universitätsbibliothek der Freien Universität Berlin) |
| locations[2].source.host_organization | https://openalex.org/I75951250 |
| locations[2].source.host_organization_name | Freie Universität Berlin |
| locations[2].source.host_organization_lineage | https://openalex.org/I75951250 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://refubium.fu-berlin.de/handle/fub188/31492 |
| locations[2].version | submittedVersion |
| locations[2].raw_type | doc-type:article |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://refubium.fu-berlin.de/handle/fub188/31492 |
| locations[3].id | pmh:oai:researchportal.port.ac.uk:publications/f92bca0f-75fa-4f50-8925-d389706210a9 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401774 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Portsmouth Research Portal (University of Portsmouth) |
| locations[3].source.host_organization | https://openalex.org/I63072094 |
| locations[3].source.host_organization_name | University of Portsmouth |
| locations[3].source.host_organization_lineage | https://openalex.org/I63072094 |
| locations[3].license | other-oa |
| locations[3].pdf_url | https://researchportal.port.ac.uk/portal/en/publications/positive-selection-in-gene-regulatory-factors-suggests-adaptive-pleiotropic-changes-during-human-evolution(f92bca0f-75fa-4f50-8925-d389706210a9).html |
| locations[3].version | submittedVersion |
| locations[3].raw_type | |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | |
| locations[4].id | pmh:oai:doaj.org/article:50891f2924434a0da163498ea06ea42b |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | cc-by-sa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Frontiers in Genetics, Vol 12 (2021) |
| locations[4].landing_page_url | https://doaj.org/article/50891f2924434a0da163498ea06ea42b |
| locations[5].id | pmh:oai:pubmedcentral.nih.gov:8166252 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S2764455111 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | PubMed Central |
| locations[5].source.host_organization | https://openalex.org/I1299303238 |
| locations[5].source.host_organization_name | National Institutes of Health |
| locations[5].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[5].license | other-oa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/other-oa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Front Genet |
| locations[5].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8166252 |
| locations[6].id | doi:10.17169/refubium-31224 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S7407052913 |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver |
| locations[6].source.host_organization | |
| locations[6].source.host_organization_name | |
| locations[6].license | cc-by |
| locations[6].pdf_url | |
| locations[6].version | |
| locations[6].raw_type | article-journal |
| locations[6].license_id | https://openalex.org/licenses/cc-by |
| locations[6].is_accepted | False |
| locations[6].is_published | |
| locations[6].raw_source_name | |
| locations[6].landing_page_url | https://doi.org/10.17169/refubium-31224 |
| indexed_in | crossref, datacite, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5052952637 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8056-5065 |
| authorships[0].author.display_name | Vladimir Jovanović |
| authorships[0].countries | DE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[0].affiliations[0].raw_affiliation_string | Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I75951250 |
| authorships[0].affiliations[1].raw_affiliation_string | Bioinformatics Solution Center, Freie Universität Berlin, Berlin, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I75951250 |
| authorships[0].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[0].institutions[0].country_code | DE |
| authorships[0].institutions[0].display_name | Freie Universität Berlin |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Vladimir M. Jovanovic |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Bioinformatics Solution Center, Freie Universität Berlin, Berlin, Germany, Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| authorships[1].author.id | https://openalex.org/A5036889767 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Melanie Sarfert |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[1].affiliations[0].raw_affiliation_string | Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I75951250 |
| authorships[1].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Freie Universität Berlin |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Melanie Sarfert |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| authorships[2].author.id | https://openalex.org/A5015303830 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7104-1446 |
| authorships[2].author.display_name | Carlos S. Reyna-Blanco |
| authorships[2].countries | CH |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I12708293 |
| authorships[2].affiliations[0].raw_affiliation_string | Swiss Institute of Bioinformatics, Fribourg, Switzerland |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I154338468 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Biology, University of Fribourg, Fribourg, Switzerland |
| authorships[2].institutions[0].id | https://openalex.org/I12708293 |
| authorships[2].institutions[0].ror | https://ror.org/002n09z45 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I12708293 |
| authorships[2].institutions[0].country_code | CH |
| authorships[2].institutions[0].display_name | SIB Swiss Institute of Bioinformatics |
| authorships[2].institutions[1].id | https://openalex.org/I154338468 |
| authorships[2].institutions[1].ror | https://ror.org/022fs9h90 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I154338468 |
| authorships[2].institutions[1].country_code | CH |
| authorships[2].institutions[1].display_name | University of Fribourg |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Carlos S. Reyna-Blanco |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biology, University of Fribourg, Fribourg, Switzerland, Swiss Institute of Bioinformatics, Fribourg, Switzerland |
| authorships[3].author.id | https://openalex.org/A5019431996 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2810-5272 |
| authorships[3].author.display_name | Henrike Indrischek |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210148197 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Systems Biology Dresden, Dresden, Germany |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I4210159854 |
| authorships[3].affiliations[1].raw_affiliation_string | Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I4210111875 |
| authorships[3].affiliations[2].raw_affiliation_string | Max Planck Institute for the Physics of Complex Systems, Dresden, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I4210148197 |
| authorships[3].institutions[0].ror | https://ror.org/05hrn3e05 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I149899117, https://openalex.org/I4210111875, https://openalex.org/I4210148197, https://openalex.org/I4210159854, https://openalex.org/I78650965 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | Center for Systems Biology Dresden |
| authorships[3].institutions[1].id | https://openalex.org/I4210111875 |
| authorships[3].institutions[1].ror | https://ror.org/01bf9rw71 |
| authorships[3].institutions[1].type | facility |
| authorships[3].institutions[1].lineage | https://openalex.org/I149899117, https://openalex.org/I4210111875 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | Max Planck Institute for the Physics of Complex Systems |
| authorships[3].institutions[2].id | https://openalex.org/I4210159854 |
| authorships[3].institutions[2].ror | https://ror.org/05b8d3w18 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I149899117, https://openalex.org/I4210159854 |
| authorships[3].institutions[2].country_code | DE |
| authorships[3].institutions[2].display_name | Max Planck Institute of Molecular Cell Biology and Genetics |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Henrike Indrischek |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Systems Biology Dresden, Dresden, Germany, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany |
| authorships[4].author.id | https://openalex.org/A5081293756 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7702-652X |
| authorships[4].author.display_name | Dulce I. Valdivia |
| authorships[4].countries | MX |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I68368234 |
| authorships[4].affiliations[0].raw_affiliation_string | Evolutionary Genomics Laboratory and Genome Topology and Regulation Laboratory, Genetic Engineering Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-Irapuato), Irapuato, Mexico |
| authorships[4].institutions[0].id | https://openalex.org/I68368234 |
| authorships[4].institutions[0].ror | https://ror.org/009eqmr18 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I59361560, https://openalex.org/I68368234 |
| authorships[4].institutions[0].country_code | MX |
| authorships[4].institutions[0].display_name | Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Dulce I. Valdivia |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Evolutionary Genomics Laboratory and Genome Topology and Regulation Laboratory, Genetic Engineering Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-Irapuato), Irapuato, Mexico |
| authorships[5].author.id | https://openalex.org/A5030772081 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-9751-6702 |
| authorships[5].author.display_name | Ekaterina Shelest |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I63072094 |
| authorships[5].affiliations[0].raw_affiliation_string | Centre for Enzyme Innovation, University of Portsmouth, Portsmouth, United Kingdom |
| authorships[5].institutions[0].id | https://openalex.org/I63072094 |
| authorships[5].institutions[0].ror | https://ror.org/03ykbk197 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I63072094 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | University of Portsmouth |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ekaterina Shelest |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Centre for Enzyme Innovation, University of Portsmouth, Portsmouth, United Kingdom |
| authorships[6].author.id | https://openalex.org/A5078414184 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3993-4479 |
| authorships[6].author.display_name | Katja Nowick |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I75951250 |
| authorships[6].affiliations[0].raw_affiliation_string | Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I75951250 |
| authorships[6].institutions[0].ror | https://ror.org/046ak2485 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I75951250 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Freie Universität Berlin |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Katja Nowick |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Human Biology and Primate Evolution, Freie Universität Berlin, Berlin, Germany |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fgene.2021.662239 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10222 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Genomics and Chromatin Dynamics |
| related_works | https://openalex.org/W1969895229, https://openalex.org/W2108497208, https://openalex.org/W2123445896, https://openalex.org/W4210708634, https://openalex.org/W2105402788, https://openalex.org/W2137351413, https://openalex.org/W2156272823, https://openalex.org/W2279684808, https://openalex.org/W2160515792, https://openalex.org/W2227014354 |
| cited_by_count | 18 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 4 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 2 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 2 |
| locations_count | 7 |
| best_oa_location.id | doi:10.3389/fgene.2021.662239 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597340651 |
| best_oa_location.source.issn | 1664-8021 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-8021 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Genetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Genetics |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fgene.2021.662239 |
| primary_location.id | doi:10.3389/fgene.2021.662239 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597340651 |
| primary_location.source.issn | 1664-8021 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-8021 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Genetics |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Genetics |
| primary_location.landing_page_url | https://doi.org/10.3389/fgene.2021.662239 |
| publication_date | 2021-05-17 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2158757265, https://openalex.org/W2805750982, https://openalex.org/W2951555158, https://openalex.org/W3036685809, https://openalex.org/W2057456873, https://openalex.org/W2054239174, https://openalex.org/W2887556343, https://openalex.org/W3091866222, https://openalex.org/W2047657819, https://openalex.org/W2910586282, https://openalex.org/W2149013762, https://openalex.org/W2102207875, https://openalex.org/W3094967361, https://openalex.org/W2093319492, https://openalex.org/W2009132217, https://openalex.org/W2015350814, https://openalex.org/W2565936489, https://openalex.org/W2170725292, https://openalex.org/W2117790117, https://openalex.org/W1972275087, https://openalex.org/W2118398017, https://openalex.org/W2156643192, https://openalex.org/W2950581144, https://openalex.org/W2542228716, https://openalex.org/W2118569683, https://openalex.org/W2762173626, https://openalex.org/W2145825942, https://openalex.org/W2143019537, https://openalex.org/W2107934935, https://openalex.org/W2081360068, https://openalex.org/W2160714946, https://openalex.org/W2914448591, https://openalex.org/W2167133711, https://openalex.org/W2116100197, https://openalex.org/W3102072560, https://openalex.org/W2152676665, https://openalex.org/W2013565107, https://openalex.org/W2162594452, https://openalex.org/W2125548284, https://openalex.org/W2570437395, https://openalex.org/W1974116356, https://openalex.org/W2167408170, https://openalex.org/W2178663509, https://openalex.org/W2150377670, https://openalex.org/W2065258504, https://openalex.org/W2967767587, https://openalex.org/W2593488635, https://openalex.org/W2594086611, https://openalex.org/W2053117901, https://openalex.org/W1999382115, https://openalex.org/W3087189116, https://openalex.org/W2160378127, https://openalex.org/W2750857187, https://openalex.org/W2148592476, https://openalex.org/W2014279841, https://openalex.org/W2128969076, https://openalex.org/W2154770881, https://openalex.org/W2807521829, https://openalex.org/W2799524357, https://openalex.org/W2982725072, https://openalex.org/W2097101746, https://openalex.org/W2785792383, https://openalex.org/W2013018787, https://openalex.org/W2025943989, https://openalex.org/W2086802511, https://openalex.org/W2144874189, https://openalex.org/W1977765763, https://openalex.org/W2080183225, https://openalex.org/W2158074993, https://openalex.org/W2003515720, https://openalex.org/W2023123230, https://openalex.org/W2118982822, https://openalex.org/W2294521862, https://openalex.org/W2149947519, https://openalex.org/W1987378985, https://openalex.org/W2102791585, https://openalex.org/W2014018250, https://openalex.org/W2048019749, https://openalex.org/W2028106094, https://openalex.org/W2014342923, https://openalex.org/W1541700566, https://openalex.org/W2981415106, https://openalex.org/W2982521190, https://openalex.org/W2883251903, https://openalex.org/W1711977572, https://openalex.org/W2900184763, https://openalex.org/W1994332522, https://openalex.org/W2949335099, https://openalex.org/W1992454389, https://openalex.org/W2283648003, https://openalex.org/W2114794895, https://openalex.org/W2036287649, https://openalex.org/W1976209715, https://openalex.org/W2156866331, https://openalex.org/W2982659388, https://openalex.org/W2068272494, https://openalex.org/W2951796795, https://openalex.org/W2108531576, https://openalex.org/W2921723567, https://openalex.org/W2611898308, https://openalex.org/W2951780082, https://openalex.org/W3009307274, https://openalex.org/W2076617993, https://openalex.org/W2388521039, https://openalex.org/W2950954328, https://openalex.org/W3028418616, https://openalex.org/W2523033879, https://openalex.org/W2046183549, https://openalex.org/W2900569176, https://openalex.org/W2104302872, https://openalex.org/W3136918052, https://openalex.org/W2951911911, https://openalex.org/W1208845046, https://openalex.org/W2132023322, https://openalex.org/W2025253353, https://openalex.org/W1981723163, https://openalex.org/W2077723503, https://openalex.org/W2105754268, https://openalex.org/W3112069035, https://openalex.org/W2070072684, https://openalex.org/W1965409500, https://openalex.org/W2081212776, https://openalex.org/W4251447235, https://openalex.org/W2089806726, https://openalex.org/W2012354488, https://openalex.org/W2805762937, https://openalex.org/W2753973561, https://openalex.org/W2110335151, https://openalex.org/W2029549914, https://openalex.org/W4206037526, https://openalex.org/W2158614739, https://openalex.org/W3090459450, https://openalex.org/W1978811100, https://openalex.org/W4301156742, https://openalex.org/W1965859094, https://openalex.org/W2136119836, https://openalex.org/W2746749479 |
| referenced_works_count | 137 |
| abstract_inverted_index.a | 62, 196, 260 |
| abstract_inverted_index.26 | 107 |
| abstract_inverted_index.27 | 47 |
| abstract_inverted_index.In | 191 |
| abstract_inverted_index.TF | 78 |
| abstract_inverted_index.To | 33, 84 |
| abstract_inverted_index.We | 110 |
| abstract_inverted_index.as | 5 |
| abstract_inverted_index.be | 267 |
| abstract_inverted_index.by | 165, 179 |
| abstract_inverted_index.in | 16, 20, 46, 72, 90, 106, 202, 262, 302, 336 |
| abstract_inverted_index.it | 280 |
| abstract_inverted_index.of | 37, 87, 120, 126, 147, 156, 258, 291 |
| abstract_inverted_index.on | 131, 224, 236, 245, 270 |
| abstract_inverted_index.or | 274 |
| abstract_inverted_index.to | 28, 39, 143, 193, 198, 253, 287, 333 |
| abstract_inverted_index.we | 42, 93, 172, 206, 326 |
| abstract_inverted_index.For | 256 |
| abstract_inverted_index.GRF | 44, 91, 230, 317 |
| abstract_inverted_index.Our | 138, 211 |
| abstract_inverted_index.TFs | 71 |
| abstract_inverted_index.all | 73, 82, 284 |
| abstract_inverted_index.and | 9, 31, 124, 134, 158, 162, 185, 228, 248 |
| abstract_inverted_index.ape | 136, 188, 239 |
| abstract_inverted_index.are | 243, 296 |
| abstract_inverted_index.box | 64 |
| abstract_inverted_index.but | 279 |
| abstract_inverted_index.can | 266 |
| abstract_inverted_index.for | 54, 115, 168, 177, 323 |
| abstract_inverted_index.has | 232 |
| abstract_inverted_index.one | 229 |
| abstract_inverted_index.per | 77 |
| abstract_inverted_index.the | 68, 118, 121, 127, 132, 145, 174, 203, 225, 237, 271, 292 |
| abstract_inverted_index.two | 112 |
| abstract_inverted_index.Four | 290 |
| abstract_inverted_index.GRFs | 38, 99, 218, 242, 295, 330 |
| abstract_inverted_index.Gene | 0, 75 |
| abstract_inverted_index.PAML | 122 |
| abstract_inverted_index.They | 23 |
| abstract_inverted_index.ZNFs | 60 |
| abstract_inverted_index.also | 25 |
| abstract_inverted_index.arms | 308 |
| abstract_inverted_index.been | 26, 221, 233, 250 |
| abstract_inverted_index.both | 166 |
| abstract_inverted_index.date | 197 |
| abstract_inverted_index.each | 314 |
| abstract_inverted_index.five | 217 |
| abstract_inverted_index.gene | 18 |
| abstract_inverted_index.have | 24, 220, 249 |
| abstract_inverted_index.high | 215 |
| abstract_inverted_index.many | 13 |
| abstract_inverted_index.more | 95, 102 |
| abstract_inverted_index.most | 69 |
| abstract_inverted_index.only | 160 |
| abstract_inverted_index.play | 12 |
| abstract_inverted_index.race | 309 |
| abstract_inverted_index.role | 261 |
| abstract_inverted_index.some | 257 |
| abstract_inverted_index.such | 4 |
| abstract_inverted_index.than | 96, 103 |
| abstract_inverted_index.that | 219, 231, 282, 299, 328 |
| abstract_inverted_index.them | 259 |
| abstract_inverted_index.they | 283 |
| abstract_inverted_index.were | 67 |
| abstract_inverted_index.with | 61, 100, 214, 276, 310, 321 |
| abstract_inverted_index.work | 212 |
| abstract_inverted_index.zinc | 55 |
| abstract_inverted_index.(ZNF) | 57 |
| abstract_inverted_index.3,000 | 97 |
| abstract_inverted_index.Genes | 52 |
| abstract_inverted_index.HyPhy | 128 |
| abstract_inverted_index.Since | 313 |
| abstract_inverted_index.These | 241 |
| abstract_inverted_index.based | 269 |
| abstract_inverted_index.data. | 190 |
| abstract_inverted_index.false | 148 |
| abstract_inverted_index.genes | 45, 92, 161, 304 |
| abstract_inverted_index.great | 135, 187, 238 |
| abstract_inverted_index.human | 98, 133, 184, 204, 209, 226, 277, 288 |
| abstract_inverted_index.order | 192 |
| abstract_inverted_index.roles | 15 |
| abstract_inverted_index.seems | 281 |
| abstract_inverted_index.signs | 86 |
| abstract_inverted_index.sites | 163, 176, 201, 320 |
| abstract_inverted_index.suite | 123 |
| abstract_inverted_index.tests | 114, 167 |
| abstract_inverted_index.their | 101, 181 |
| abstract_inverted_index.these | 329 |
| abstract_inverted_index.(KRAB) | 65 |
| abstract_inverted_index.70,000 | 104 |
| abstract_inverted_index.aBSREL | 125 |
| abstract_inverted_index.and/or | 264, 306 |
| abstract_inverted_index.assign | 195 |
| abstract_inverted_index.coding | 53 |
| abstract_inverted_index.detect | 85 |
| abstract_inverted_index.domain | 66 |
| abstract_inverted_index.family | 79 |
| abstract_inverted_index.finger | 56 |
| abstract_inverted_index.induce | 300 |
| abstract_inverted_index.linked | 252 |
| abstract_inverted_index.manual | 154 |
| abstract_inverted_index.number | 146 |
| abstract_inverted_index.reduce | 144 |
| abstract_inverted_index.suite, | 129 |
| abstract_inverted_index.target | 303 |
| abstract_inverted_index.within | 183 |
| abstract_inverted_index.(GRFs), | 3 |
| abstract_inverted_index.archaic | 208 |
| abstract_inverted_index.between | 81 |
| abstract_inverted_index.branch. | 137 |
| abstract_inverted_index.changes | 301 |
| abstract_inverted_index.diverse | 254 |
| abstract_inverted_index.factors | 2 |
| abstract_inverted_index.humans. | 337 |
| abstract_inverted_index.lineage | 227 |
| abstract_inverted_index.numbers | 76 |
| abstract_inverted_index.pattern | 273 |
| abstract_inverted_index.primate | 40, 50 |
| abstract_inverted_index.several | 319 |
| abstract_inverted_index.similar | 152 |
| abstract_inverted_index.suggest | 327 |
| abstract_inverted_index.through | 307 |
| abstract_inverted_index.KRAB-ZNF | 297 |
| abstract_inverted_index.abundant | 70 |
| abstract_inverted_index.analyzed | 43, 207 |
| abstract_inverted_index.contains | 318 |
| abstract_inverted_index.detected | 164 |
| abstract_inverted_index.differed | 80 |
| abstract_inverted_index.enzymes, | 11 |
| abstract_inverted_index.evidence | 322 |
| abstract_inverted_index.factors, | 7 |
| abstract_inverted_index.focusing | 130 |
| abstract_inverted_index.genomes. | 51, 74, 210 |
| abstract_inverted_index.included | 140 |
| abstract_inverted_index.lineage, | 205 |
| abstract_inverted_index.lineage. | 240 |
| abstract_inverted_index.positive | 88, 116, 169, 324 |
| abstract_inverted_index.proposed | 27, 268 |
| abstract_inverted_index.publicly | 48 |
| abstract_inverted_index.revealed | 213 |
| abstract_inverted_index.rigorous | 141 |
| abstract_inverted_index.selected | 200, 223, 235, 294, 316 |
| abstract_inverted_index.species. | 83 |
| abstract_inverted_index.underlie | 29 |
| abstract_inverted_index.verified | 173 |
| abstract_inverted_index.workflow | 139 |
| abstract_inverted_index.available | 49 |
| abstract_inverted_index.candidate | 175 |
| abstract_inverted_index.different | 246 |
| abstract_inverted_index.diseases, | 278 |
| abstract_inverted_index.distantly | 151 |
| abstract_inverted_index.elements. | 312 |
| abstract_inverted_index.excluding | 150 |
| abstract_inverted_index.important | 14 |
| abstract_inverted_index.modifying | 17 |
| abstract_inverted_index.non-human | 108, 186 |
| abstract_inverted_index.orthologs | 105 |
| abstract_inverted_index.potential | 35 |
| abstract_inverted_index.primates. | 109 |
| abstract_inverted_index.proteins, | 58, 298 |
| abstract_inverted_index.scattered | 244 |
| abstract_inverted_index.selection | 89, 178 |
| abstract_inverted_index.variation | 182 |
| abstract_inverted_index.adaptation | 265 |
| abstract_inverted_index.biological | 21 |
| abstract_inverted_index.co-factors | 8 |
| abstract_inverted_index.confidence | 216 |
| abstract_inverted_index.especially | 59 |
| abstract_inverted_index.evolution, | 41 |
| abstract_inverted_index.evolution. | 289 |
| abstract_inverted_index.expression | 19, 272 |
| abstract_inverted_index.functions. | 255 |
| abstract_inverted_index.orthologs, | 153 |
| abstract_inverted_index.phenotypic | 334 |
| abstract_inverted_index.population | 189 |
| abstract_inverted_index.positively | 199, 222, 234, 293, 315 |
| abstract_inverted_index.positives: | 149 |
| abstract_inverted_index.previously | 251 |
| abstract_inverted_index.procedures | 142 |
| abstract_inverted_index.processes. | 22 |
| abstract_inverted_index.regulatory | 1 |
| abstract_inverted_index.selection, | 117, 325 |
| abstract_inverted_index.selection. | 170 |
| abstract_inverted_index.speciation | 30, 263 |
| abstract_inverted_index.adaptation. | 32 |
| abstract_inverted_index.adaptations | 335 |
| abstract_inverted_index.alignments, | 157 |
| abstract_inverted_index.association | 275 |
| abstract_inverted_index.chromosomes | 247 |
| abstract_inverted_index.considering | 159 |
| abstract_inverted_index.contributed | 285 |
| abstract_inverted_index.corrections | 155 |
| abstract_inverted_index.implemented | 111 |
| abstract_inverted_index.independent | 113 |
| abstract_inverted_index.investigate | 34 |
| abstract_inverted_index.Furthermore, | 171 |
| abstract_inverted_index.investigated | 94 |
| abstract_inverted_index.participated | 331 |
| abstract_inverted_index.transposable | 311 |
| abstract_inverted_index.approximately | 194 |
| abstract_inverted_index.co-expression | 305 |
| abstract_inverted_index.contributions | 36 |
| abstract_inverted_index.independently | 286 |
| abstract_inverted_index.investigating | 180 |
| abstract_inverted_index.transcription | 6 |
| abstract_inverted_index.pleiotropically | 332 |
| abstract_inverted_index.branch-site-model | 119 |
| abstract_inverted_index.histone-modifying | 10 |
| abstract_inverted_index.Krüppel-associated | 63 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5078414184 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I75951250 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.75832448 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |