Possible molecular basis of the biochemical effects of cysteine-derived persulfides Article Swipe
Ernesto Cuevasanta
,
Dayana Benchoam
,
Jonathan A. Semelak
,
Matías N. Möller
,
Ari Zeida
,
Madia Trujillo
,
Beatriz Álvarez
,
Darío A. Estrı́n
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2022.975988
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2022.975988
Persulfides (RSSH/RSS − ) are species closely related to thiols (RSH/RS − ) and hydrogen sulfide (H 2 S/HS − ), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds. They are key intermediates in catabolic and biosynthetic processes, and have been proposed to participate in the transduction of hydrogen sulfide effects. Persulfides are acidic, more acidic than thiols, and the persulfide anions are expected to be the predominant species at neutral pH. The persulfide anion has high nucleophilicity, due in part to the alpha effect, i.e., the increased reactivity of a nucleophile when the neighboring atom has high electron density. In addition, persulfides have electrophilic character, a property that is absent in both thiols and hydrogen sulfide. In this article, the biochemistry of persulfides is described, and the possible ways in which the formation of a persulfide could impact on the properties of the biomolecule involved are discussed.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2022.975988
- https://www.frontiersin.org/articles/10.3389/fmolb.2022.975988/pdf
- OA Status
- gold
- Cited By
- 14
- References
- 53
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4297009497Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmolb.2022.975988Digital Object Identifier
- Title
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Possible molecular basis of the biochemical effects of cysteine-derived persulfidesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-23Full publication date if available
- Authors
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Ernesto Cuevasanta, Dayana Benchoam, Jonathan A. Semelak, Matías N. Möller, Ari Zeida, Madia Trujillo, Beatriz Álvarez, Darío A. Estrı́nList of authors in order
- Landing page
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https://doi.org/10.3389/fmolb.2022.975988Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmolb.2022.975988/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmolb.2022.975988/pdfDirect OA link when available
- Concepts
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Chemistry, Nucleophile, Cysteine, Reactivity (psychology), Hydrogen sulfide, Electrophile, Sulfide, Sulfur, Organic chemistry, Enzyme, Catalysis, Medicine, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2, 2023: 8Per-year citation counts (last 5 years)
- References (count)
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53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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