Post COVID-19 condition among individuals hospitalized during Wave 1 and Wave 2 at Mulago National Referral Hospital and Entebbe Regional Referral Hospital, Uganda, 2020-2021 Article Swipe
Allan Komakech
,
Edirisa Nsubuga Juniour
,
Judith Drazidio
,
Stella Martha Migamba
,
Daniel Kadobera
,
Lilian Bulage
,
Benon Kwesiga
,
Alex Ario Riolexus
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3404242/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3404242/v1
Introduction: The presence of long-term symptoms among COVID-19 survivors is referred to as Post COVID-19 condition (PCC). In Uganda, the burden of PCC is unknown. We described the spectrum of and risk factors for PCC among persons hospitalized with COVID-19 to inform decision-making. Methods We conducted a retrospective cohort study among randomly-selected COVID-19 survivors hospitalized at Mulago and Entebbe Referral Hospitals during Wave 1 (October 2020-December 2020) and Wave 2 (May 2021-June 2021) of the pandemic in Uganda. A PCC case was defined as persistent, returning, or new COVID-19 symptoms occurring during the 4–12 weeks after onset for non-severe disease and during the 8–12 weeks from onset for severe disease, without an alternative diagnosis in a person with confirmed SARS-CoV-2 infection. Patients were contacted by phone, and risk factors for PCC were established using modified Poisson regression. Findings: Among 798 COVID-19 survivors (Wave 1: 391; Wave 2: 407), we identified 63 (16%) cases of PCC in Wave 1 and 81 (20%) in Wave 2. In Wave 1, common PCC symptoms included chest pain (14; 18%) and cough (11; 14%), while Wave 2 patients reported fatigue (16; 20%) and cough (16; 20%). Severe disease (aIRR = 2.0, 95%CI: 1.4–2.6) and any comorbidity (aIRR = 1.9, 95%CI: 1.2–2.8) during Wave 1 and any comorbidity (aIRR = 2.6, 95% CI 2.1–3.3) during Wave 2 were associated with PCC. Interpretation: Approximately 1 in 5 previously-hospitalized COVID-19 survivors experienced PCC during both waves, emphasizing the need for close follow-up and appropriate post-COVID-19 care.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3404242/v1
- https://www.researchsquare.com/article/rs-3404242/latest.pdf
- OA Status
- green
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387311329
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387311329Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-3404242/v1Digital Object Identifier
- Title
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Post COVID-19 condition among individuals hospitalized during Wave 1 and Wave 2 at Mulago National Referral Hospital and Entebbe Regional Referral Hospital, Uganda, 2020-2021Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-03Full publication date if available
- Authors
-
Allan Komakech, Edirisa Nsubuga Juniour, Judith Drazidio, Stella Martha Migamba, Daniel Kadobera, Lilian Bulage, Benon Kwesiga, Alex Ario RiolexusList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3404242/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-3404242/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3404242/latest.pdfDirect OA link when available
- Concepts
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Medicine, Referral, Comorbidity, Internal medicine, Poisson regression, Retrospective cohort study, Coronavirus disease 2019 (COVID-19), Cohort, Tertiary referral hospital, Cohort study, Disease, Pediatrics, Population, Family medicine, Infectious disease (medical specialty), Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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18Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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