Posttransplant cyclophosphamide in HLA-matched and 1-2 allele mismatched peripheral blood stem cell transplantation Article Swipe
Takanori Teshima
,
Junichi Sugita
,
Takashi Kuroha
,
Jun Ishikawa
,
Tetsuya Eto
,
Kentaro Fukushima
,
Isao Yokota
,
Koichi Akashi
,
Mine Harada
,
Shuichi Taniguchi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3238671/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3238671/v1
Posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis has been increasingly used in HLA-haploidentical transplantation and recent studies also demonstrated the efficacy of PTCy in HLA-matched transplantation. However, data on PTCy in HLA 1–2 allele mismatched transplants are limited. We conducted a prospective multicenter phase II study to evaluate the safety and efficacy of PTCy with tacrolimus and mycophenolate mofetil in 43 patients who underwent HLA-matched (n = 21) or HLA 1–2 allele mismatched (n = 22) peripheral blood stem cell transplantation (PBSCT) following myeloablative (n = 28) or reduced-intensity (n = 15) conditioning. The incidence of grade III-IV acute GVHD at 100 days was 2.3%. The incidences of grades II-IV acute GVHD, all grade chronic GVHD, and moderate to severe chronic GVHD at 2 years were 16.3%, 14.0%, and 4.7%, respectively. Overall survival, disease-free survival, and non-relapse mortality at 2 years were 75.3%, 74.0%, and 7.0%, respectively. GVHD-free, relapse-free survival at 2 years was 67.0%. The rate of off-immunosuppressants in patients who survived without relapse at 2 years was 85.4%. These results indicate that PTCy is a valid option for GVHD prophylaxis in both HLA-matched and HLA 1–2 allele mismatched PBSCT.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3238671/v1
- https://www.researchsquare.com/article/rs-3238671/latest.pdf
- OA Status
- green
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386951452
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386951452Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3238671/v1Digital Object Identifier
- Title
-
Posttransplant cyclophosphamide in HLA-matched and 1-2 allele mismatched peripheral blood stem cell transplantationWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-22Full publication date if available
- Authors
-
Takanori Teshima, Junichi Sugita, Takashi Kuroha, Jun Ishikawa, Tetsuya Eto, Kentaro Fukushima, Isao Yokota, Koichi Akashi, Mine Harada, Shuichi TaniguchiList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-3238671/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-3238671/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3238671/latest.pdfDirect OA link when available
- Concepts
-
Allele, Human leukocyte antigen, Cyclophosphamide, Peripheral blood, Peripheral, Transplantation, Stem cell, Medicine, Immunology, Biology, Genetics, Internal medicine, Chemotherapy, Antigen, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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