Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico Approaches Article Swipe
Vanderlan Nogueira Holanda
,
Thaíse G. S. Brito
,
João Ricardhis Saturnino de Oliveira
,
Rebeca Xavier da Cunha
,
Ana Paula Sant’Anna da Silva
,
Welson Vicente da Silva
,
Tiago Ferreira da Silva Araújo
,
Josean Fechine Tavares
,
Sócrates Golzio dos Santos
,
Regina Célia Bressan Queiroz de Figueiredo
,
Vera Lúcia de Menezes Lima
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms12010207
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms12010207
In the search for new chemotherapeutic alternatives for cutaneous leishmaniasis (CL), essential oils are promising due to their diverse biological potential. In this study, we aimed to investigate the chemical composition and leishmanicidal and anti-inflammatory potential of the essential oil isolated from the leaves of Plinia cauliflora (PCEO). The chemical composition of PCEO showed β-cis-Caryophyllene (24.4%), epi-γ-Eudesmol (8%), 2-Naphthalenemethanol[decahydro-alpha] (8%), and trans-Calamenene (6.6%) as its major constituents. Our results showed that the PCEO has moderate cytotoxicity (CC50) of 137.4 and 143.7 μg/mL on mice peritoneal exudate cells (mPEC) and Vero cells, respectively. The PCEO was able to significantly decrease mPEC infection by Leishmania amazonensis and Leishmania braziliensis. The value of the inhibitory concentration (IC50) on amastigote forms was about 7.3 µg/mL (L. amazonensis) and 7.2 µg/mL (L. braziliensis). We showed that PCEO induced drastic ultrastructural changes in both species of Leishmania and had a high selectivity index (SI) > 18. The in silico ADMET analysis pointed out that PCEO can be used for the development of oral and/or topical formulation in the treatment of CL. In addition, we also demonstrated the in vivo anti-inflammatory effect, with a 95% reduction in paw edema and a decrease by at least 21.4% in migration immune cells in animals treated with 50 mg/kg of PCEO. Taken together, our results demonstrate that PCEO is a promising topical therapeutic agent against CL.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/microorganisms12010207
- https://www.mdpi.com/2076-2607/12/1/207/pdf?version=1705662235
- OA Status
- gold
- Cited By
- 1
- References
- 100
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391026184
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391026184Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/microorganisms12010207Digital Object Identifier
- Title
-
Potential Effects of Essential Oil from Plinia cauliflora (Mart.) Kausel on Leishmania: In Vivo, In Vitro, and In Silico ApproachesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-19Full publication date if available
- Authors
-
Vanderlan Nogueira Holanda, Thaíse G. S. Brito, João Ricardhis Saturnino de Oliveira, Rebeca Xavier da Cunha, Ana Paula Sant’Anna da Silva, Welson Vicente da Silva, Tiago Ferreira da Silva Araújo, Josean Fechine Tavares, Sócrates Golzio dos Santos, Regina Célia Bressan Queiroz de Figueiredo, Vera Lúcia de Menezes LimaList of authors in order
- Landing page
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https://doi.org/10.3390/microorganisms12010207Publisher landing page
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https://www.mdpi.com/2076-2607/12/1/207/pdf?version=1705662235Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-2607/12/1/207/pdf?version=1705662235Direct OA link when available
- Concepts
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Amastigote, In vivo, In silico, IC50, Leishmania, Leishmania braziliensis, Pharmacology, Cytotoxicity, In vitro, Exudate, Chemistry, Biology, Leishmaniasis, Vero cell, Microbiology, Cutaneous leishmaniasis, Biochemistry, Botany, Immunology, Biotechnology, Parasite hosting, World Wide Web, Computer science, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.143.7 | 80 |
| abstract_inverted_index.21.4% | 198 |
| abstract_inverted_index.ADMET | 153 |
| abstract_inverted_index.PCEO. | 210 |
| abstract_inverted_index.Taken | 211 |
| abstract_inverted_index.about | 118 |
| abstract_inverted_index.agent | 223 |
| abstract_inverted_index.aimed | 25 |
| abstract_inverted_index.cells | 86, 202 |
| abstract_inverted_index.edema | 191 |
| abstract_inverted_index.forms | 116 |
| abstract_inverted_index.index | 146 |
| abstract_inverted_index.least | 197 |
| abstract_inverted_index.major | 65 |
| abstract_inverted_index.mg/kg | 208 |
| abstract_inverted_index.their | 17 |
| abstract_inverted_index.value | 108 |
| abstract_inverted_index.(6.6%) | 62 |
| abstract_inverted_index.(CC50) | 76 |
| abstract_inverted_index.(IC50) | 113 |
| abstract_inverted_index.(mPEC) | 87 |
| abstract_inverted_index.Plinia | 45 |
| abstract_inverted_index.and/or | 167 |
| abstract_inverted_index.cells, | 90 |
| abstract_inverted_index.immune | 201 |
| abstract_inverted_index.leaves | 43 |
| abstract_inverted_index.search | 2 |
| abstract_inverted_index.showed | 53, 69, 129 |
| abstract_inverted_index.silico | 152 |
| abstract_inverted_index.study, | 23 |
| abstract_inverted_index.µg/mL | 120, 125 |
| abstract_inverted_index.μg/mL | 81 |
| abstract_inverted_index.(PCEO). | 47 |
| abstract_inverted_index.against | 224 |
| abstract_inverted_index.animals | 204 |
| abstract_inverted_index.changes | 135 |
| abstract_inverted_index.diverse | 18 |
| abstract_inverted_index.drastic | 133 |
| abstract_inverted_index.effect, | 184 |
| abstract_inverted_index.exudate | 85 |
| abstract_inverted_index.induced | 132 |
| abstract_inverted_index.pointed | 155 |
| abstract_inverted_index.results | 68, 214 |
| abstract_inverted_index.species | 138 |
| abstract_inverted_index.topical | 168, 221 |
| abstract_inverted_index.treated | 205 |
| abstract_inverted_index.(24.4%), | 55 |
| abstract_inverted_index.analysis | 154 |
| abstract_inverted_index.chemical | 29, 49 |
| abstract_inverted_index.decrease | 98, 194 |
| abstract_inverted_index.isolated | 40 |
| abstract_inverted_index.moderate | 74 |
| abstract_inverted_index.addition, | 176 |
| abstract_inverted_index.cutaneous | 8 |
| abstract_inverted_index.essential | 11, 38 |
| abstract_inverted_index.infection | 100 |
| abstract_inverted_index.migration | 200 |
| abstract_inverted_index.potential | 35 |
| abstract_inverted_index.promising | 14, 220 |
| abstract_inverted_index.reduction | 188 |
| abstract_inverted_index.together, | 212 |
| abstract_inverted_index.treatment | 172 |
| abstract_inverted_index.Leishmania | 102, 105, 140 |
| abstract_inverted_index.amastigote | 115 |
| abstract_inverted_index.biological | 19 |
| abstract_inverted_index.cauliflora | 46 |
| abstract_inverted_index.inhibitory | 111 |
| abstract_inverted_index.peritoneal | 84 |
| abstract_inverted_index.potential. | 20 |
| abstract_inverted_index.amazonensis | 103 |
| abstract_inverted_index.composition | 30, 50 |
| abstract_inverted_index.demonstrate | 215 |
| abstract_inverted_index.development | 164 |
| abstract_inverted_index.formulation | 169 |
| abstract_inverted_index.investigate | 27 |
| abstract_inverted_index.selectivity | 145 |
| abstract_inverted_index.therapeutic | 222 |
| abstract_inverted_index.alternatives | 6 |
| abstract_inverted_index.amazonensis) | 122 |
| abstract_inverted_index.cytotoxicity | 75 |
| abstract_inverted_index.demonstrated | 179 |
| abstract_inverted_index.braziliensis. | 106 |
| abstract_inverted_index.concentration | 112 |
| abstract_inverted_index.constituents. | 66 |
| abstract_inverted_index.leishmaniasis | 9 |
| abstract_inverted_index.respectively. | 91 |
| abstract_inverted_index.significantly | 97 |
| abstract_inverted_index.braziliensis). | 127 |
| abstract_inverted_index.leishmanicidal | 32 |
| abstract_inverted_index.epi-γ-Eudesmol | 56 |
| abstract_inverted_index.ultrastructural | 134 |
| abstract_inverted_index.chemotherapeutic | 5 |
| abstract_inverted_index.trans-Calamenene | 61 |
| abstract_inverted_index.anti-inflammatory | 34, 183 |
| abstract_inverted_index.β-cis-Caryophyllene | 54 |
| abstract_inverted_index.2-Naphthalenemethanol[decahydro-alpha] | 58 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5056180426, https://openalex.org/A5069983719 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I25112270 |
| citation_normalized_percentile.value | 0.67322067 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |