Potential effects of Linh Loc Son hard capsule – a Vietnamese herbal combination in immunodeficiency induced by cyclophosphamide on mice Article Swipe
Binh Quoc Pham
,
Thị Kim Ngân Nguyên
,
Su Quoc Pham
,
Duy Cuong Nguyen
,
Lam Vu Trinh
,
Đinh Thị Thu Hằng
,
Quang Vinh Trịnh
,
Pham Thi Van Anh
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.56499/jppres23.1751_12.5.892
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.56499/jppres23.1751_12.5.892
Context: Traditional medicine and herbal extracts have long been recognized for their immunomodulatory effects, enhancing patient immune responses. The use of traditional medicine to target specific pathogens and support the immune system is increasingly studied. Linh Loc Son (LLS) hard capsule, a product derived from nature, consists of the main four natural ingredients: Curculigo orchioides Gaertn., Dioscorea persimilis Prain et Burk., Morinda officinalis F.C.How. and Fallopia multiflora (Thunb.) Haraldson. Aims: To evaluate the potential effects of LLS hard capsules in complementary treatment of immunodeficiency state in mice. Methods: An experiment was conducted to assess the impact of LLS hard capsules on an immunosuppressed model of cyclophosphamide-induced Swiss mice of either sex. Two doses of LLS hard capsules (0.69 and 1.38 g/kg body weight) and levamisole (100 mg/kg body weight), serving as a positive control, were administered orally for seven consecutive days; cyclophosphamide (200 mg/kg i.p.) was administered on the fourth day. Results: Both doses of LLS hard capsule did insignificantly ameliorate the immunosuppressive effects of cyclophosphamide on the delayed-type hypersensitivity response but maintained leukocyte counts, relative organ weight, and cytokines as compared to the levamisole group and showed a significant improvement in micro-histological images. Conclusions: This study has demonstrated in vivo the immunostimulatory effect of LLS hard capsules, highlighting their potential to boost and regulate the immune response in mice models of immunodeficiency.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.56499/jppres23.1751_12.5.892
- https://jppres.com/jppres/pdf/vol12/jppres23.1751_12.5.892.pdf
- OA Status
- diamond
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394903508
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394903508Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.56499/jppres23.1751_12.5.892Digital Object Identifier
- Title
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Potential effects of Linh Loc Son hard capsule – a Vietnamese herbal combination in immunodeficiency induced by cyclophosphamide on miceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-17Full publication date if available
- Authors
-
Binh Quoc Pham, Thị Kim Ngân Nguyên, Su Quoc Pham, Duy Cuong Nguyen, Lam Vu Trinh, Đinh Thị Thu Hằng, Quang Vinh Trịnh, Pham Thi Van AnhList of authors in order
- Landing page
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https://doi.org/10.56499/jppres23.1751_12.5.892Publisher landing page
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https://jppres.com/jppres/pdf/vol12/jppres23.1751_12.5.892.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://jppres.com/jppres/pdf/vol12/jppres23.1751_12.5.892.pdfDirect OA link when available
- Concepts
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Levamisole, Cyclophosphamide, Traditional medicine, Context (archaeology), Immune system, Pharmacology, Medicine, Immunodeficiency, Capsule, Immunology, Biology, Internal medicine, Botany, Chemotherapy, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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22Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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