Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) Article Swipe
Michela Perrone
,
Martina Pagano
,
Carmela Belardo
,
Flavia Ricciardi
,
Federica Ricciardi
,
Antimo Fusco
,
Maria Consiglia Trotta
,
Rosmara Infantino
,
Francesca Gargano
,
Andrea Parente
,
Rosa Giacca
,
Gorizio Pieretti
,
Livio Luongo
,
Sabatino Maione
,
Serena Boccella
,
Francesca Guida
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neuropharm.2023.109456
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.neuropharm.2023.109456
Following insults or injury, microglia cells are activated contributing to the cytotoxic response or by promoting an immune-mediated damage resolution. Microglia cells express HCA2R, a hydroxy carboxylic acid (HCA) receptor, which has been shown to mediate neuroprotective and anti-inflammatory effects. In this study we found that HCAR2 expression levels were increased in cultured rat microglia cells after Lipopolysaccharide (LPS) exposure. In a similar fashion, the treatment with MK 1903, a potent full agonist of HCAR2, increased the receptor protein levels. Moreover, HCAR2 stimulation prevented i) cells viability ii) morphological activation iii) pro/anti-inflammatory mediators production in LPS-treated cells. Likewise, HCAR2 stimulation reduced the proinflammatory mediators mRNA expression induced by neuronal chemokine fractalkine (FKN), a neuronal derived chemokine activating its unique receptor, chemokine receptor 1 (CX3CR1) on microglia surface. Interestingly, electrophysiological recordings in vivo revealed that MK1903 was able to prevent the increase of the nociceptive neurons (NS) firing activity mediated by the spinal FKN application in healthy rats. Collectively, our data demonstrate that HCAR2 is functionally expressed in microglia, by showing its capability to shift microglia toward an anti-inflammatory phenotype. Moreover, we indicated the contribute of HCAR2 in the FKN signaling and suggested a possible HCAR2/CX3CR1 functional interaction. This study paves the way for further investigations aimed at understanding the role HCAR2 as potential target in neuroinflammation-based CNS disorders. This article is part of the Special Issue on "The receptor-receptor interaction as a new target for therapy".
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.neuropharm.2023.109456
- OA Status
- hybrid
- Cited By
- 12
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4320718912
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4320718912Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.neuropharm.2023.109456Digital Object Identifier
- Title
-
Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1)Work title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-14Full publication date if available
- Authors
-
Michela Perrone, Martina Pagano, Carmela Belardo, Flavia Ricciardi, Federica Ricciardi, Antimo Fusco, Maria Consiglia Trotta, Rosmara Infantino, Francesca Gargano, Andrea Parente, Rosa Giacca, Gorizio Pieretti, Livio Luongo, Sabatino Maione, Serena Boccella, Francesca GuidaList of authors in order
- Landing page
-
https://doi.org/10.1016/j.neuropharm.2023.109456Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.neuropharm.2023.109456Direct OA link when available
- Concepts
-
Microglia, CX3CR1, Neuroinflammation, Chemokine, Neuroprotection, Receptor, Agonist, Cell biology, Lipopolysaccharide, Chemokine receptor, Stimulation, Chemistry, Biology, Pharmacology, Immunology, Neuroscience, Inflammation, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 2, 2023: 6Per-year citation counts (last 5 years)
- References (count)
-
41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4320718912 |
|---|---|
| doi | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| ids.doi | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36796675 |
| ids.openalex | https://openalex.org/W4320718912 |
| fwci | 2.66730455 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D051381 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Rats |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D017628 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Microglia |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D019743 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Chemokines, CXC |
| mesh[4].qualifier_ui | Q000494 |
| mesh[4].descriptor_ui | D019743 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | pharmacology |
| mesh[4].descriptor_name | Chemokines, CXC |
| mesh[5].qualifier_ui | Q000494 |
| mesh[5].descriptor_ui | D008070 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pharmacology |
| mesh[5].descriptor_name | Lipopolysaccharides |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D000073883 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | CX3C Chemokine Receptor 1 |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D054428 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Chemokine CX3CL1 |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D019707 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Receptors, Chemokine |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D019707 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Receptors, Chemokine |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D051381 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Rats |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000818 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Animals |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D017628 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Microglia |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D019743 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Chemokines, CXC |
| mesh[14].qualifier_ui | Q000494 |
| mesh[14].descriptor_ui | D019743 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | pharmacology |
| mesh[14].descriptor_name | Chemokines, CXC |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D008070 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Lipopolysaccharides |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D000073883 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | CX3C Chemokine Receptor 1 |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D054428 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Chemokine CX3CL1 |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D019707 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Receptors, Chemokine |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D019707 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Receptors, Chemokine |
| type | review |
| title | Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) |
| biblio.issue | |
| biblio.volume | 228 |
| biblio.last_page | 109456 |
| biblio.first_page | 109456 |
| topics[0].id | https://openalex.org/T11266 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2808 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| topics[1].id | https://openalex.org/T11193 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9929999709129333 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1314 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Adenosine and Purinergic Signaling |
| topics[2].id | https://openalex.org/T10608 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.9919999837875366 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2806 |
| topics[2].subfield.display_name | Developmental Neuroscience |
| topics[2].display_name | Neurogenesis and neuroplasticity mechanisms |
| is_xpac | False |
| apc_list.value | 4050 |
| apc_list.currency | USD |
| apc_list.value_usd | 4050 |
| apc_paid.value | 4050 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4050 |
| concepts[0].id | https://openalex.org/C2779830541 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8812582492828369 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1622829 |
| concepts[0].display_name | Microglia |
| concepts[1].id | https://openalex.org/C31179232 |
| concepts[1].level | 5 |
| concepts[1].score | 0.8744432926177979 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14911549 |
| concepts[1].display_name | CX3CR1 |
| concepts[2].id | https://openalex.org/C87753298 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6796329617500305 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q17157137 |
| concepts[2].display_name | Neuroinflammation |
| concepts[3].id | https://openalex.org/C13373296 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6683295965194702 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q421866 |
| concepts[3].display_name | Chemokine |
| concepts[4].id | https://openalex.org/C25498285 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6328739523887634 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1981368 |
| concepts[4].display_name | Neuroprotection |
| concepts[5].id | https://openalex.org/C170493617 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5339682698249817 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[5].display_name | Receptor |
| concepts[6].id | https://openalex.org/C2778938600 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5334197878837585 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q389934 |
| concepts[6].display_name | Agonist |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4996767044067383 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C2778754761 |
| concepts[8].level | 2 |
| concepts[8].score | 0.46207740902900696 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q421804 |
| concepts[8].display_name | Lipopolysaccharide |
| concepts[9].id | https://openalex.org/C12823836 |
| concepts[9].level | 4 |
| concepts[9].score | 0.4593830704689026 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q24720618 |
| concepts[9].display_name | Chemokine receptor |
| concepts[10].id | https://openalex.org/C24998067 |
| concepts[10].level | 2 |
| concepts[10].score | 0.4429031014442444 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q4114622 |
| concepts[10].display_name | Stimulation |
| concepts[11].id | https://openalex.org/C185592680 |
| concepts[11].level | 0 |
| concepts[11].score | 0.39216405153274536 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[11].display_name | Chemistry |
| concepts[12].id | https://openalex.org/C86803240 |
| concepts[12].level | 0 |
| concepts[12].score | 0.38516485691070557 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[12].display_name | Biology |
| concepts[13].id | https://openalex.org/C98274493 |
| concepts[13].level | 1 |
| concepts[13].score | 0.3668411374092102 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[13].display_name | Pharmacology |
| concepts[14].id | https://openalex.org/C203014093 |
| concepts[14].level | 1 |
| concepts[14].score | 0.3444124460220337 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[14].display_name | Immunology |
| concepts[15].id | https://openalex.org/C169760540 |
| concepts[15].level | 1 |
| concepts[15].score | 0.3279992938041687 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[15].display_name | Neuroscience |
| concepts[16].id | https://openalex.org/C2776914184 |
| concepts[16].level | 2 |
| concepts[16].score | 0.3007403612136841 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[16].display_name | Inflammation |
| concepts[17].id | https://openalex.org/C55493867 |
| concepts[17].level | 1 |
| concepts[17].score | 0.10916492342948914 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[17].display_name | Biochemistry |
| keywords[0].id | https://openalex.org/keywords/microglia |
| keywords[0].score | 0.8812582492828369 |
| keywords[0].display_name | Microglia |
| keywords[1].id | https://openalex.org/keywords/cx3cr1 |
| keywords[1].score | 0.8744432926177979 |
| keywords[1].display_name | CX3CR1 |
| keywords[2].id | https://openalex.org/keywords/neuroinflammation |
| keywords[2].score | 0.6796329617500305 |
| keywords[2].display_name | Neuroinflammation |
| keywords[3].id | https://openalex.org/keywords/chemokine |
| keywords[3].score | 0.6683295965194702 |
| keywords[3].display_name | Chemokine |
| keywords[4].id | https://openalex.org/keywords/neuroprotection |
| keywords[4].score | 0.6328739523887634 |
| keywords[4].display_name | Neuroprotection |
| keywords[5].id | https://openalex.org/keywords/receptor |
| keywords[5].score | 0.5339682698249817 |
| keywords[5].display_name | Receptor |
| keywords[6].id | https://openalex.org/keywords/agonist |
| keywords[6].score | 0.5334197878837585 |
| keywords[6].display_name | Agonist |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.4996767044067383 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/lipopolysaccharide |
| keywords[8].score | 0.46207740902900696 |
| keywords[8].display_name | Lipopolysaccharide |
| keywords[9].id | https://openalex.org/keywords/chemokine-receptor |
| keywords[9].score | 0.4593830704689026 |
| keywords[9].display_name | Chemokine receptor |
| keywords[10].id | https://openalex.org/keywords/stimulation |
| keywords[10].score | 0.4429031014442444 |
| keywords[10].display_name | Stimulation |
| keywords[11].id | https://openalex.org/keywords/chemistry |
| keywords[11].score | 0.39216405153274536 |
| keywords[11].display_name | Chemistry |
| keywords[12].id | https://openalex.org/keywords/biology |
| keywords[12].score | 0.38516485691070557 |
| keywords[12].display_name | Biology |
| keywords[13].id | https://openalex.org/keywords/pharmacology |
| keywords[13].score | 0.3668411374092102 |
| keywords[13].display_name | Pharmacology |
| keywords[14].id | https://openalex.org/keywords/immunology |
| keywords[14].score | 0.3444124460220337 |
| keywords[14].display_name | Immunology |
| keywords[15].id | https://openalex.org/keywords/neuroscience |
| keywords[15].score | 0.3279992938041687 |
| keywords[15].display_name | Neuroscience |
| keywords[16].id | https://openalex.org/keywords/inflammation |
| keywords[16].score | 0.3007403612136841 |
| keywords[16].display_name | Inflammation |
| keywords[17].id | https://openalex.org/keywords/biochemistry |
| keywords[17].score | 0.10916492342948914 |
| keywords[17].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1016/j.neuropharm.2023.109456 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S160566677 |
| locations[0].source.issn | 0028-3908, 1873-7064 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0028-3908 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Neuropharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Neuropharmacology |
| locations[0].landing_page_url | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| locations[1].id | pmid:36796675 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Neuropharmacology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36796675 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5024703117 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3284-9944 |
| authorships[0].author.display_name | Michela Perrone |
| authorships[0].countries | IT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[0].institutions[0].id | https://openalex.org/I197809005 |
| authorships[0].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[0].institutions[0].country_code | IT |
| authorships[0].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Michela Perrone |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[1].author.id | https://openalex.org/A5103924946 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Martina Pagano |
| authorships[1].countries | IT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[1].institutions[0].id | https://openalex.org/I197809005 |
| authorships[1].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[1].institutions[0].country_code | IT |
| authorships[1].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Martina Pagano |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[2].author.id | https://openalex.org/A5058587477 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7588-462X |
| authorships[2].author.display_name | Carmela Belardo |
| authorships[2].countries | IT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[2].institutions[0].id | https://openalex.org/I197809005 |
| authorships[2].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[2].institutions[0].country_code | IT |
| authorships[2].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Carmela Belardo |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[3].author.id | https://openalex.org/A5037181770 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7914-0054 |
| authorships[3].author.display_name | Flavia Ricciardi |
| authorships[3].countries | IT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[3].institutions[0].id | https://openalex.org/I197809005 |
| authorships[3].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[3].institutions[0].country_code | IT |
| authorships[3].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Flavia Ricciardi |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[4].author.id | https://openalex.org/A5030405728 |
| authorships[4].author.orcid | https://orcid.org/0009-0007-0036-7610 |
| authorships[4].author.display_name | Federica Ricciardi |
| authorships[4].countries | IT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[4].institutions[0].id | https://openalex.org/I197809005 |
| authorships[4].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[4].institutions[0].country_code | IT |
| authorships[4].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Federica Ricciardi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[5].author.id | https://openalex.org/A5088443427 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Antimo Fusco |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[5].institutions[0].id | https://openalex.org/I197809005 |
| authorships[5].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Antimo Fusco |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[6].author.id | https://openalex.org/A5071787420 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9813-5955 |
| authorships[6].author.display_name | Maria Consiglia Trotta |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I197809005 |
| authorships[6].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Maria Consiglia Trotta |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[7].author.id | https://openalex.org/A5075697614 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-1266-6881 |
| authorships[7].author.display_name | Rosmara Infantino |
| authorships[7].countries | IT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[7].institutions[0].id | https://openalex.org/I197809005 |
| authorships[7].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[7].institutions[0].country_code | IT |
| authorships[7].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Rosmara Infantino |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[8].author.id | https://openalex.org/A5029420275 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-5415-9776 |
| authorships[8].author.display_name | Francesca Gargano |
| authorships[8].countries | IT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I155125353 |
| authorships[8].affiliations[0].raw_affiliation_string | Unit of Anaesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University of Rome, 00128, Rome, Italy |
| authorships[8].institutions[0].id | https://openalex.org/I155125353 |
| authorships[8].institutions[0].ror | https://ror.org/04gqx4x78 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I155125353 |
| authorships[8].institutions[0].country_code | IT |
| authorships[8].institutions[0].display_name | Università Campus Bio-Medico |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Francesca Gargano |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Unit of Anaesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University of Rome, 00128, Rome, Italy |
| authorships[9].author.id | https://openalex.org/A5031527816 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-0153-7419 |
| authorships[9].author.display_name | Andrea Parente |
| authorships[9].countries | IT |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Precision Medicine, Division of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[9].institutions[0].id | https://openalex.org/I197809005 |
| authorships[9].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[9].institutions[0].country_code | IT |
| authorships[9].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Andrea Parente |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Precision Medicine, Division of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[10].author.id | https://openalex.org/A5073744583 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Rosa Giacca |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Precision Medicine, Division of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[10].institutions[0].id | https://openalex.org/I197809005 |
| authorships[10].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Rosa Giacca |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Precision Medicine, Division of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[11].author.id | https://openalex.org/A5038716705 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Gorizio Pieretti |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[11].affiliations[0].raw_affiliation_string | Multidisciplinary Department of Surgical and Dental Specialities, University of Campania "Luigi Vanvitelli", Naples, Italy |
| authorships[11].institutions[0].id | https://openalex.org/I197809005 |
| authorships[11].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Gorizio Pieretti |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Multidisciplinary Department of Surgical and Dental Specialities, University of Campania "Luigi Vanvitelli", Naples, Italy |
| authorships[12].author.id | https://openalex.org/A5052789598 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-1949-2039 |
| authorships[12].author.display_name | Livio Luongo |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[12].institutions[0].id | https://openalex.org/I197809005 |
| authorships[12].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Livio Luongo |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[13].author.id | https://openalex.org/A5061433350 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-3850-6704 |
| authorships[13].author.display_name | Sabatino Maione |
| authorships[13].countries | IT |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[13].institutions[0].id | https://openalex.org/I197809005 |
| authorships[13].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[13].institutions[0].country_code | IT |
| authorships[13].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Sabatino Maione |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[14].author.id | https://openalex.org/A5049717032 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-3632-3536 |
| authorships[14].author.display_name | Serena Boccella |
| authorships[14].countries | IT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[14].institutions[0].id | https://openalex.org/I197809005 |
| authorships[14].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[14].institutions[0].country_code | IT |
| authorships[14].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Serena Boccella |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[15].author.id | https://openalex.org/A5002742138 |
| authorships[15].author.orcid | https://orcid.org/0000-0003-0759-9602 |
| authorships[15].author.display_name | Francesca Guida |
| authorships[15].countries | IT |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I197809005 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| authorships[15].institutions[0].id | https://openalex.org/I197809005 |
| authorships[15].institutions[0].ror | https://ror.org/02kqnpp86 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I197809005 |
| authorships[15].institutions[0].country_code | IT |
| authorships[15].institutions[0].display_name | University of Campania "Luigi Vanvitelli" |
| authorships[15].author_position | last |
| authorships[15].raw_author_name | Francesca Guida |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Experimental Medicine, Division of Pharmacology, University of Campania "L. Vanvitelli", Naples, Italy |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11266 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2808 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| related_works | https://openalex.org/W2965172925, https://openalex.org/W4230243208, https://openalex.org/W2086776463, https://openalex.org/W2804482952, https://openalex.org/W1534609954, https://openalex.org/W4310076785, https://openalex.org/W3107395714, https://openalex.org/W2914543850, https://openalex.org/W2759712270, https://openalex.org/W2162232325 |
| cited_by_count | 12 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 4 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1016/j.neuropharm.2023.109456 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S160566677 |
| best_oa_location.source.issn | 0028-3908, 1873-7064 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0028-3908 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Neuropharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Neuropharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| primary_location.id | doi:10.1016/j.neuropharm.2023.109456 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S160566677 |
| primary_location.source.issn | 0028-3908, 1873-7064 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0028-3908 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Neuropharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Neuropharmacology |
| primary_location.landing_page_url | https://doi.org/10.1016/j.neuropharm.2023.109456 |
| publication_date | 2023-02-14 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3151462065, https://openalex.org/W2002879327, https://openalex.org/W2885291208, https://openalex.org/W2033663189, https://openalex.org/W2164655074, https://openalex.org/W2003299171, https://openalex.org/W2056688527, https://openalex.org/W1970167467, https://openalex.org/W2787493940, https://openalex.org/W2104996587, https://openalex.org/W2097703897, https://openalex.org/W2791714167, https://openalex.org/W3023008267, https://openalex.org/W2165451741, https://openalex.org/W3165686315, https://openalex.org/W2163179762, https://openalex.org/W2067267561, https://openalex.org/W2044219916, https://openalex.org/W1973251099, https://openalex.org/W1891953138, https://openalex.org/W2068128655, https://openalex.org/W2108995593, https://openalex.org/W1588041244, https://openalex.org/W2004243328, https://openalex.org/W2137225377, https://openalex.org/W1768846296, https://openalex.org/W2970175082, https://openalex.org/W2151241903, https://openalex.org/W1995089232, https://openalex.org/W2296643995, https://openalex.org/W2053141700, https://openalex.org/W6798630817, https://openalex.org/W6718150349, https://openalex.org/W2554390311, https://openalex.org/W2135340760, https://openalex.org/W1602487811, https://openalex.org/W2158025896, https://openalex.org/W2035340550, https://openalex.org/W2052193782, https://openalex.org/W2434245728, https://openalex.org/W3183462396 |
| referenced_works_count | 41 |
| abstract_inverted_index.1 | 122 |
| abstract_inverted_index.a | 24, 61, 69, 112, 192, 231 |
| abstract_inverted_index.In | 40, 60 |
| abstract_inverted_index.MK | 67 |
| abstract_inverted_index.an | 16, 176 |
| abstract_inverted_index.as | 211, 230 |
| abstract_inverted_index.at | 206 |
| abstract_inverted_index.by | 14, 107, 149, 168 |
| abstract_inverted_index.i) | 84 |
| abstract_inverted_index.in | 51, 94, 130, 154, 166, 186, 214 |
| abstract_inverted_index.is | 163, 220 |
| abstract_inverted_index.of | 73, 141, 184, 222 |
| abstract_inverted_index.on | 124, 226 |
| abstract_inverted_index.or | 2, 13 |
| abstract_inverted_index.to | 9, 34, 137, 172 |
| abstract_inverted_index.we | 43, 180 |
| abstract_inverted_index.CNS | 216 |
| abstract_inverted_index.FKN | 152, 188 |
| abstract_inverted_index.and | 37, 190 |
| abstract_inverted_index.are | 6 |
| abstract_inverted_index.for | 202, 234 |
| abstract_inverted_index.has | 31 |
| abstract_inverted_index.ii) | 87 |
| abstract_inverted_index.its | 117, 170 |
| abstract_inverted_index.new | 232 |
| abstract_inverted_index.our | 158 |
| abstract_inverted_index.rat | 53 |
| abstract_inverted_index.the | 10, 64, 76, 101, 139, 142, 150, 182, 187, 200, 208, 223 |
| abstract_inverted_index.was | 135 |
| abstract_inverted_index.way | 201 |
| abstract_inverted_index."The | 227 |
| abstract_inverted_index.(NS) | 145 |
| abstract_inverted_index.This | 197, 218 |
| abstract_inverted_index.able | 136 |
| abstract_inverted_index.acid | 27 |
| abstract_inverted_index.been | 32 |
| abstract_inverted_index.data | 159 |
| abstract_inverted_index.full | 71 |
| abstract_inverted_index.iii) | 90 |
| abstract_inverted_index.mRNA | 104 |
| abstract_inverted_index.part | 221 |
| abstract_inverted_index.role | 209 |
| abstract_inverted_index.that | 45, 133, 161 |
| abstract_inverted_index.this | 41 |
| abstract_inverted_index.vivo | 131 |
| abstract_inverted_index.were | 49 |
| abstract_inverted_index.with | 66 |
| abstract_inverted_index.(HCA) | 28 |
| abstract_inverted_index.(LPS) | 58 |
| abstract_inverted_index.1903, | 68 |
| abstract_inverted_index.HCAR2 | 46, 81, 98, 162, 185, 210 |
| abstract_inverted_index.Issue | 225 |
| abstract_inverted_index.after | 56 |
| abstract_inverted_index.aimed | 205 |
| abstract_inverted_index.cells | 5, 21, 55, 85 |
| abstract_inverted_index.found | 44 |
| abstract_inverted_index.paves | 199 |
| abstract_inverted_index.rats. | 156 |
| abstract_inverted_index.shift | 173 |
| abstract_inverted_index.shown | 33 |
| abstract_inverted_index.study | 42, 198 |
| abstract_inverted_index.which | 30 |
| abstract_inverted_index.(FKN), | 111 |
| abstract_inverted_index.HCA2R, | 23 |
| abstract_inverted_index.HCAR2, | 74 |
| abstract_inverted_index.MK1903 | 134 |
| abstract_inverted_index.cells. | 96 |
| abstract_inverted_index.damage | 18 |
| abstract_inverted_index.firing | 146 |
| abstract_inverted_index.levels | 48 |
| abstract_inverted_index.potent | 70 |
| abstract_inverted_index.spinal | 151 |
| abstract_inverted_index.target | 213, 233 |
| abstract_inverted_index.toward | 175 |
| abstract_inverted_index.unique | 118 |
| abstract_inverted_index.Special | 224 |
| abstract_inverted_index.agonist | 72 |
| abstract_inverted_index.article | 219 |
| abstract_inverted_index.derived | 114 |
| abstract_inverted_index.express | 22 |
| abstract_inverted_index.further | 203 |
| abstract_inverted_index.healthy | 155 |
| abstract_inverted_index.hydroxy | 25 |
| abstract_inverted_index.induced | 106 |
| abstract_inverted_index.injury, | 3 |
| abstract_inverted_index.insults | 1 |
| abstract_inverted_index.levels. | 79 |
| abstract_inverted_index.mediate | 35 |
| abstract_inverted_index.neurons | 144 |
| abstract_inverted_index.prevent | 138 |
| abstract_inverted_index.protein | 78 |
| abstract_inverted_index.reduced | 100 |
| abstract_inverted_index.showing | 169 |
| abstract_inverted_index.similar | 62 |
| abstract_inverted_index.(CX3CR1) | 123 |
| abstract_inverted_index.activity | 147 |
| abstract_inverted_index.cultured | 52 |
| abstract_inverted_index.effects. | 39 |
| abstract_inverted_index.fashion, | 63 |
| abstract_inverted_index.increase | 140 |
| abstract_inverted_index.mediated | 148 |
| abstract_inverted_index.neuronal | 108, 113 |
| abstract_inverted_index.possible | 193 |
| abstract_inverted_index.receptor | 77, 121 |
| abstract_inverted_index.response | 12 |
| abstract_inverted_index.revealed | 132 |
| abstract_inverted_index.surface. | 126 |
| abstract_inverted_index.Following | 0 |
| abstract_inverted_index.Likewise, | 97 |
| abstract_inverted_index.Microglia | 20 |
| abstract_inverted_index.Moreover, | 80, 179 |
| abstract_inverted_index.activated | 7 |
| abstract_inverted_index.chemokine | 109, 115, 120 |
| abstract_inverted_index.cytotoxic | 11 |
| abstract_inverted_index.exposure. | 59 |
| abstract_inverted_index.expressed | 165 |
| abstract_inverted_index.increased | 50, 75 |
| abstract_inverted_index.indicated | 181 |
| abstract_inverted_index.mediators | 92, 103 |
| abstract_inverted_index.microglia | 4, 54, 125, 174 |
| abstract_inverted_index.potential | 212 |
| abstract_inverted_index.prevented | 83 |
| abstract_inverted_index.promoting | 15 |
| abstract_inverted_index.receptor, | 29, 119 |
| abstract_inverted_index.signaling | 189 |
| abstract_inverted_index.suggested | 191 |
| abstract_inverted_index.therapy". | 235 |
| abstract_inverted_index.treatment | 65 |
| abstract_inverted_index.viability | 86 |
| abstract_inverted_index.activating | 116 |
| abstract_inverted_index.activation | 89 |
| abstract_inverted_index.capability | 171 |
| abstract_inverted_index.carboxylic | 26 |
| abstract_inverted_index.contribute | 183 |
| abstract_inverted_index.disorders. | 217 |
| abstract_inverted_index.expression | 47, 105 |
| abstract_inverted_index.functional | 195 |
| abstract_inverted_index.microglia, | 167 |
| abstract_inverted_index.phenotype. | 178 |
| abstract_inverted_index.production | 93 |
| abstract_inverted_index.recordings | 129 |
| abstract_inverted_index.LPS-treated | 95 |
| abstract_inverted_index.application | 153 |
| abstract_inverted_index.demonstrate | 160 |
| abstract_inverted_index.fractalkine | 110 |
| abstract_inverted_index.interaction | 229 |
| abstract_inverted_index.nociceptive | 143 |
| abstract_inverted_index.resolution. | 19 |
| abstract_inverted_index.stimulation | 82, 99 |
| abstract_inverted_index.HCAR2/CX3CR1 | 194 |
| abstract_inverted_index.contributing | 8 |
| abstract_inverted_index.functionally | 164 |
| abstract_inverted_index.interaction. | 196 |
| abstract_inverted_index.Collectively, | 157 |
| abstract_inverted_index.morphological | 88 |
| abstract_inverted_index.understanding | 207 |
| abstract_inverted_index.Interestingly, | 127 |
| abstract_inverted_index.investigations | 204 |
| abstract_inverted_index.immune-mediated | 17 |
| abstract_inverted_index.neuroprotective | 36 |
| abstract_inverted_index.proinflammatory | 102 |
| abstract_inverted_index.anti-inflammatory | 38, 177 |
| abstract_inverted_index.receptor-receptor | 228 |
| abstract_inverted_index.Lipopolysaccharide | 57 |
| abstract_inverted_index.electrophysiological | 128 |
| abstract_inverted_index.pro/anti-inflammatory | 91 |
| abstract_inverted_index.neuroinflammation-based | 215 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5061433350, https://openalex.org/A5052789598 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I197809005 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.84723305 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |