Potential Role of the Micro-Immunotherapy Medicine 2LALERG in the Treatment of Pollen-Induced Allergic Inflammation Article Swipe
Ilaria Floris
,
Pauline Chenuet
,
Dieudonnée Togbe
,
Christelle Volteau
,
Béatrice Lejeune
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1177/1559325820914092
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1177/1559325820914092
In this study, we evaluated the efficacy of a micro-immunotherapy medicine (MIM), 2LALERG, in a preclinical model of allergic respiratory disease sensitized with birch pollen extract (BPE). BALB/c mice were immunized with BPE, or saline solution, and were then challenged. Micro-immunotherapy medicine pillules were diluted in water, and 3 doses (0.75; 1.5; 3 mg/mouse) were tested and compared to vehicle control (3 mg/mouse). Treatments and vehicle were orally administered by gavage for 10 days. Micro-immunotherapy medicine (0.75 mg/mouse) reduced the number of total cells as well as the levels of interleukin (IL)-13 in bronchoalveolar lavage fluid (BALF) compared to vehicle control. Eosinophils in BALF tended to be lower compared to vehicle group, and the difference is close to significance. Histological analysis in the lungs confirms a moderate effect of MIM (0.75 mg/mice) on inflammatory infiltration and mucus production. Serum levels of IL-5 in MIM (0.75 mg/mouse)-treated mice were lower compared to vehicle; IL-4 levels tended to be lower too. Total immunoglobulin E (IgE) decreased in serum of MIM (1.5 and 0.75 mg/mouse) groups compared to vehicle control. Micro-immunotherapy medicine exerted the highest effect at the lowest dose tested. Micro-immunotherapy medicine resolved the local and systemic inflammation, even if partially, in a model of pollen-induced, IgE-mediated inflammation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1559325820914092
- https://journals.sagepub.com/doi/pdf/10.1177/1559325820914092
- OA Status
- gold
- Cited By
- 18
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3013168088
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3013168088Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/1559325820914092Digital Object Identifier
- Title
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Potential Role of the Micro-Immunotherapy Medicine 2LALERG in the Treatment of Pollen-Induced Allergic InflammationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-01Full publication date if available
- Authors
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Ilaria Floris, Pauline Chenuet, Dieudonnée Togbe, Christelle Volteau, Béatrice LejeuneList of authors in order
- Landing page
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https://doi.org/10.1177/1559325820914092Publisher landing page
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https://journals.sagepub.com/doi/pdf/10.1177/1559325820914092Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://journals.sagepub.com/doi/pdf/10.1177/1559325820914092Direct OA link when available
- Concepts
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Immunotherapy, Bronchoalveolar lavage, Medicine, Immunoglobulin E, Inflammation, Immunology, Saline, Pharmacology, Immune system, Antibody, Internal medicine, LungTop concepts (fields/topics) attached by OpenAlex
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18Total citation count in OpenAlex
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2025: 2, 2024: 5, 2023: 2, 2022: 4, 2021: 4Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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