bioRxiv (Cold Spring Harbor Laboratory)
Potentiation of Adipogenesis by Reactive Oxygen Species is a Unifying Mechanism in the Pro-adipogenic Properties of Bisphenol A and its New Structural Analogues
September 2022 • Radha Dutt Singh, Jessica L. Wager, Taylor B. Scheidl, Liam Connors, Sarah Easson, Mikyla A. Callaghan, Samuel Alatorre-Hinojosa, Lucy Swift, Pina Co…
ABSTRACT Aims Structural analogues of bisphenol A (BPA), including BPS and BPF, are emerging environmental toxicants as their presence in the environment is rising since new regulatory restrictions were placed on BPA-containing infant products. The adipogenesis-enhancing effect of bisphenols may explain the link between human exposure and metabolic disease; however, underlying molecular pathways remain unresolved. Results Exposure to BPS, BPF, BPA or ROS generators enhanced lipid droplet formation and expression o…