Practical Considerations in Dose Extrapolation from Animals to Humans Article Swipe
Anthony J. Hickey
,
Sara E. Maloney
,
Philip J. Kuehl
,
Jonathan E. Phillips
,
Ronald K. Wolff
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1089/jamp.2023.0041
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1089/jamp.2023.0041
Animal studies are an important component of drug product development and the regulatory review process since modern practices have been in place, for almost a century. A variety of experimental systems are available to generate aerosols for delivery to animals in both liquid and solid forms. The extrapolation of deposited dose in the lungs from laboratory animals to humans is challenging because of genetic, anatomical, physiological, pharmacological, and other biological differences between species. Inhaled drug delivery extrapolation requires scrutiny as the aerodynamic behavior, and its role in lung deposition is influenced not only by the properties of the drug aerosol but also by the anatomy and pulmonary function of the species in which it is being evaluated. Sources of variability between species include the formulation, delivery system, and species-specific biological factors. It is important to acknowledge the underlying variables that contribute to estimates of dose scaling between species.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1089/jamp.2023.0041
- OA Status
- green
- Cited By
- 10
- References
- 97
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390967822
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390967822Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1089/jamp.2023.0041Digital Object Identifier
- Title
-
Practical Considerations in Dose Extrapolation from Animals to HumansWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-18Full publication date if available
- Authors
-
Anthony J. Hickey, Sara E. Maloney, Philip J. Kuehl, Jonathan E. Phillips, Ronald K. WolffList of authors in order
- Landing page
-
https://doi.org/10.1089/jamp.2023.0041Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11807867Direct OA link when available
- Concepts
-
Extrapolation, Animal species, Scrutiny, Deposition (geology), Biology, Zoology, Mathematics, Political science, Sediment, Law, Paleontology, Mathematical analysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
97Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4390967822 |
|---|---|
| doi | https://doi.org/10.1089/jamp.2023.0041 |
| ids.doi | https://doi.org/10.1089/jamp.2023.0041 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38237032 |
| ids.openalex | https://openalex.org/W4390967822 |
| fwci | 8.62623141 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D006801 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Humans |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000280 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Administration, Inhalation |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000336 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Aerosols |
| mesh[4].qualifier_ui | Q000502 |
| mesh[4].descriptor_ui | D008168 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | physiology |
| mesh[4].descriptor_name | Lung |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D016503 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Drug Delivery Systems |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D000818 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Animals |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D006801 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Humans |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000280 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Administration, Inhalation |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000336 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Aerosols |
| mesh[10].qualifier_ui | Q000502 |
| mesh[10].descriptor_ui | D008168 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | physiology |
| mesh[10].descriptor_name | Lung |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D016503 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Drug Delivery Systems |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D000818 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Animals |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D006801 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Humans |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000280 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Administration, Inhalation |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D000336 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Aerosols |
| mesh[16].qualifier_ui | Q000502 |
| mesh[16].descriptor_ui | D008168 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | physiology |
| mesh[16].descriptor_name | Lung |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D016503 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Drug Delivery Systems |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000818 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Animals |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006801 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Humans |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000280 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Administration, Inhalation |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000336 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Aerosols |
| mesh[22].qualifier_ui | Q000502 |
| mesh[22].descriptor_ui | D008168 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | physiology |
| mesh[22].descriptor_name | Lung |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D016503 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Drug Delivery Systems |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000818 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Animals |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D006801 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Humans |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000280 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Administration, Inhalation |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000336 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Aerosols |
| mesh[28].qualifier_ui | Q000502 |
| mesh[28].descriptor_ui | D008168 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | physiology |
| mesh[28].descriptor_name | Lung |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D016503 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Drug Delivery Systems |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D000818 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Animals |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D006801 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Humans |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D000280 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Administration, Inhalation |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D000336 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Aerosols |
| mesh[34].qualifier_ui | Q000502 |
| mesh[34].descriptor_ui | D008168 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | physiology |
| mesh[34].descriptor_name | Lung |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D016503 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Drug Delivery Systems |
| type | review |
| title | Practical Considerations in Dose Extrapolation from Animals to Humans |
| biblio.issue | 2 |
| biblio.volume | 37 |
| biblio.last_page | 89 |
| biblio.first_page | 77 |
| topics[0].id | https://openalex.org/T11651 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Inhalation and Respiratory Drug Delivery |
| topics[1].id | https://openalex.org/T11255 |
| topics[1].field.id | https://openalex.org/fields/22 |
| topics[1].field.display_name | Engineering |
| topics[1].score | 0.9527999758720398 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2204 |
| topics[1].subfield.display_name | Biomedical Engineering |
| topics[1].display_name | Microfluidic and Bio-sensing Technologies |
| topics[2].id | https://openalex.org/T13338 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.9297000169754028 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1103 |
| topics[2].subfield.display_name | Animal Science and Zoology |
| topics[2].display_name | Pharmacological Effects and Assays |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C132459708 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7217447757720947 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q744069 |
| concepts[0].display_name | Extrapolation |
| concepts[1].id | https://openalex.org/C2993056352 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5112571716308594 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7432 |
| concepts[1].display_name | Animal species |
| concepts[2].id | https://openalex.org/C2776050585 |
| concepts[2].level | 2 |
| concepts[2].score | 0.4288560450077057 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7439360 |
| concepts[2].display_name | Scrutiny |
| concepts[3].id | https://openalex.org/C64297162 |
| concepts[3].level | 3 |
| concepts[3].score | 0.4141963720321655 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1987070 |
| concepts[3].display_name | Deposition (geology) |
| concepts[4].id | https://openalex.org/C86803240 |
| concepts[4].level | 0 |
| concepts[4].score | 0.41319340467453003 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[4].display_name | Biology |
| concepts[5].id | https://openalex.org/C90856448 |
| concepts[5].level | 1 |
| concepts[5].score | 0.24290090799331665 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q431 |
| concepts[5].display_name | Zoology |
| concepts[6].id | https://openalex.org/C33923547 |
| concepts[6].level | 0 |
| concepts[6].score | 0.10852783918380737 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q395 |
| concepts[6].display_name | Mathematics |
| concepts[7].id | https://openalex.org/C17744445 |
| concepts[7].level | 0 |
| concepts[7].score | 0.0 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q36442 |
| concepts[7].display_name | Political science |
| concepts[8].id | https://openalex.org/C2816523 |
| concepts[8].level | 2 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q180184 |
| concepts[8].display_name | Sediment |
| concepts[9].id | https://openalex.org/C199539241 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7748 |
| concepts[9].display_name | Law |
| concepts[10].id | https://openalex.org/C151730666 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7205 |
| concepts[10].display_name | Paleontology |
| concepts[11].id | https://openalex.org/C134306372 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7754 |
| concepts[11].display_name | Mathematical analysis |
| keywords[0].id | https://openalex.org/keywords/extrapolation |
| keywords[0].score | 0.7217447757720947 |
| keywords[0].display_name | Extrapolation |
| keywords[1].id | https://openalex.org/keywords/animal-species |
| keywords[1].score | 0.5112571716308594 |
| keywords[1].display_name | Animal species |
| keywords[2].id | https://openalex.org/keywords/scrutiny |
| keywords[2].score | 0.4288560450077057 |
| keywords[2].display_name | Scrutiny |
| keywords[3].id | https://openalex.org/keywords/deposition |
| keywords[3].score | 0.4141963720321655 |
| keywords[3].display_name | Deposition (geology) |
| keywords[4].id | https://openalex.org/keywords/biology |
| keywords[4].score | 0.41319340467453003 |
| keywords[4].display_name | Biology |
| keywords[5].id | https://openalex.org/keywords/zoology |
| keywords[5].score | 0.24290090799331665 |
| keywords[5].display_name | Zoology |
| keywords[6].id | https://openalex.org/keywords/mathematics |
| keywords[6].score | 0.10852783918380737 |
| keywords[6].display_name | Mathematics |
| language | en |
| locations[0].id | doi:10.1089/jamp.2023.0041 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S148726610 |
| locations[0].source.issn | 1941-2703, 1941-2711 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1941-2703 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| locations[0].source.host_organization | https://openalex.org/P4310320443 |
| locations[0].source.host_organization_name | Mary Ann Liebert, Inc. |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320443 |
| locations[0].source.host_organization_lineage_names | Mary Ann Liebert, Inc. |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| locations[0].landing_page_url | https://doi.org/10.1089/jamp.2023.0041 |
| locations[1].id | pmid:38237032 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of aerosol medicine and pulmonary drug delivery |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38237032 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11807867 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Aerosol Med Pulm Drug Deliv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11807867 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5071846305 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-3324-9326 |
| authorships[0].author.display_name | Anthony J. Hickey |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Technology Advancement and Commercialization, RTI International, Research Triangle Park, North Carolina, USA. |
| authorships[0].institutions[0].id | https://openalex.org/I180297670 |
| authorships[0].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | RTI International |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Anthony J. Hickey |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Technology Advancement and Commercialization, RTI International, Research Triangle Park, North Carolina, USA. |
| authorships[1].author.id | https://openalex.org/A5015092281 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0114-0550 |
| authorships[1].author.display_name | Sara E. Maloney |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I180297670 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Technology Advancement and Commercialization, RTI International, Research Triangle Park, North Carolina, USA. |
| authorships[1].institutions[0].id | https://openalex.org/I180297670 |
| authorships[1].institutions[0].ror | https://ror.org/052tfza37 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I180297670 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | RTI International |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sara E. Maloney |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Technology Advancement and Commercialization, RTI International, Research Triangle Park, North Carolina, USA. |
| authorships[2].author.id | https://openalex.org/A5007070596 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-7567-3002 |
| authorships[2].author.display_name | Philip J. Kuehl |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1305258596, https://openalex.org/I99978038 |
| authorships[2].affiliations[0].raw_affiliation_string | Division: Scientific Core Laboratories; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I99978038 |
| authorships[2].affiliations[1].raw_affiliation_string | Division: Scientific Core Laboratories |
| authorships[2].institutions[0].id | https://openalex.org/I99978038 |
| authorships[2].institutions[0].ror | https://ror.org/00scjy223 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I99978038 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Core Laboratories (United States) |
| authorships[2].institutions[1].id | https://openalex.org/I1305258596 |
| authorships[2].institutions[1].ror | https://ror.org/038qbqz41 |
| authorships[2].institutions[1].type | nonprofit |
| authorships[2].institutions[1].lineage | https://openalex.org/I1305258596 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Lovelace Respiratory Research Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Philip J. Kuehl |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division: Scientific Core Laboratories, Division: Scientific Core Laboratories; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA. |
| authorships[3].author.id | https://openalex.org/A5077397336 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9036-649X |
| authorships[3].author.display_name | Jonathan E. Phillips |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1320553840 |
| authorships[3].affiliations[0].raw_affiliation_string | Amgen, Inc., Inflammation Discovery Research, Thousand Oaks, California, USA. |
| authorships[3].institutions[0].id | https://openalex.org/I1320553840 |
| authorships[3].institutions[0].ror | https://ror.org/03g03ge92 |
| authorships[3].institutions[0].type | company |
| authorships[3].institutions[0].lineage | https://openalex.org/I1320553840 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Amgen (United States) |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jonathan E. Phillips |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Amgen, Inc., Inflammation Discovery Research, Thousand Oaks, California, USA. |
| authorships[4].author.id | https://openalex.org/A5052240995 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0083-7559 |
| authorships[4].author.display_name | Ronald K. Wolff |
| authorships[4].affiliations[0].raw_affiliation_string | RK Wolff Safety Consulting, Inc., Sanibel, Florida, USA. |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Ronald K. Wolff |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | RK Wolff Safety Consulting, Inc., Sanibel, Florida, USA. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11807867 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Practical Considerations in Dose Extrapolation from Animals to Humans |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11651 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Inhalation and Respiratory Drug Delivery |
| related_works | https://openalex.org/W2082860237, https://openalex.org/W1968270095, https://openalex.org/W1987888524, https://openalex.org/W2119695867, https://openalex.org/W2415594679, https://openalex.org/W2220129715, https://openalex.org/W4296478327, https://openalex.org/W2042397106, https://openalex.org/W4361730764, https://openalex.org/W2130076355 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 9 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11807867 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | J Aerosol Med Pulm Drug Deliv |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11807867 |
| primary_location.id | doi:10.1089/jamp.2023.0041 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S148726610 |
| primary_location.source.issn | 1941-2703, 1941-2711 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1941-2703 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| primary_location.source.host_organization | https://openalex.org/P4310320443 |
| primary_location.source.host_organization_name | Mary Ann Liebert, Inc. |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320443 |
| primary_location.source.host_organization_lineage_names | Mary Ann Liebert, Inc. |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| primary_location.landing_page_url | https://doi.org/10.1089/jamp.2023.0041 |
| publication_date | 2024-01-18 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W1869177231, https://openalex.org/W2506940243, https://openalex.org/W3017834715, https://openalex.org/W2116670791, https://openalex.org/W1988083910, https://openalex.org/W2142513442, https://openalex.org/W2103128166, https://openalex.org/W27482439, https://openalex.org/W2082536219, https://openalex.org/W2027865617, https://openalex.org/W3202146938, https://openalex.org/W12858941, https://openalex.org/W1967620942, https://openalex.org/W2163465871, https://openalex.org/W2072022722, https://openalex.org/W2085530326, https://openalex.org/W3084317835, https://openalex.org/W2174332922, https://openalex.org/W1555950098, https://openalex.org/W2981811394, https://openalex.org/W2304678643, https://openalex.org/W2921215631, https://openalex.org/W2074850707, https://openalex.org/W2043599529, https://openalex.org/W4235063847, https://openalex.org/W2094621138, https://openalex.org/W2049271043, https://openalex.org/W2116790427, https://openalex.org/W2077446764, https://openalex.org/W2025283445, https://openalex.org/W2974055570, https://openalex.org/W2010291348, https://openalex.org/W127263118, https://openalex.org/W2498880630, https://openalex.org/W2037714073, https://openalex.org/W2008152807, https://openalex.org/W4234768112, https://openalex.org/W2342967196, https://openalex.org/W3197998503, https://openalex.org/W2171417511, https://openalex.org/W2265803435, https://openalex.org/W2178658875, https://openalex.org/W1984449569, https://openalex.org/W2470042529, https://openalex.org/W2484754032, https://openalex.org/W2080274119, https://openalex.org/W2070613025, https://openalex.org/W2605403970, https://openalex.org/W2120166044, https://openalex.org/W2091439004, https://openalex.org/W2059934442, https://openalex.org/W2418347507, https://openalex.org/W3044407280, https://openalex.org/W2963914914, https://openalex.org/W4385970594, https://openalex.org/W2741011619, https://openalex.org/W2954562608, https://openalex.org/W2015113396, https://openalex.org/W2988753812, https://openalex.org/W2117229986, https://openalex.org/W1613434511, https://openalex.org/W2072455585, https://openalex.org/W2016644650, https://openalex.org/W4244659296, https://openalex.org/W1992429563, https://openalex.org/W2605000431, https://openalex.org/W2344228894, https://openalex.org/W2518165966, https://openalex.org/W2071997933, https://openalex.org/W4247810498, https://openalex.org/W2141979074, https://openalex.org/W2052947420, https://openalex.org/W2005216394, https://openalex.org/W2057682847, https://openalex.org/W187655416, https://openalex.org/W2104884279, https://openalex.org/W3081488288, https://openalex.org/W2052109061, https://openalex.org/W1997451627, https://openalex.org/W2988951125, https://openalex.org/W3216568031, https://openalex.org/W3033550936, https://openalex.org/W2082232923, https://openalex.org/W2016565975, https://openalex.org/W3202377778, https://openalex.org/W3040114045, https://openalex.org/W2127596827, https://openalex.org/W3030748957, https://openalex.org/W2236096632, https://openalex.org/W2153900948, https://openalex.org/W201716594, https://openalex.org/W2947397495, https://openalex.org/W2047869803, https://openalex.org/W3023355788, https://openalex.org/W2521557118, https://openalex.org/W52274533, https://openalex.org/W2031755423 |
| referenced_works_count | 97 |
| abstract_inverted_index.A | 26 |
| abstract_inverted_index.a | 24 |
| abstract_inverted_index.It | 131 |
| abstract_inverted_index.an | 3 |
| abstract_inverted_index.as | 79 |
| abstract_inverted_index.by | 93, 102 |
| abstract_inverted_index.in | 20, 40, 51, 86, 111 |
| abstract_inverted_index.is | 59, 89, 114, 132 |
| abstract_inverted_index.it | 113 |
| abstract_inverted_index.of | 6, 28, 48, 62, 96, 108, 118, 143 |
| abstract_inverted_index.to | 33, 38, 57, 134, 141 |
| abstract_inverted_index.The | 46 |
| abstract_inverted_index.and | 10, 43, 67, 83, 105, 127 |
| abstract_inverted_index.are | 2, 31 |
| abstract_inverted_index.but | 100 |
| abstract_inverted_index.for | 22, 36 |
| abstract_inverted_index.its | 84 |
| abstract_inverted_index.not | 91 |
| abstract_inverted_index.the | 11, 52, 80, 94, 97, 103, 109, 123, 136 |
| abstract_inverted_index.also | 101 |
| abstract_inverted_index.been | 19 |
| abstract_inverted_index.both | 41 |
| abstract_inverted_index.dose | 50, 144 |
| abstract_inverted_index.drug | 7, 74, 98 |
| abstract_inverted_index.from | 54 |
| abstract_inverted_index.have | 18 |
| abstract_inverted_index.lung | 87 |
| abstract_inverted_index.only | 92 |
| abstract_inverted_index.role | 85 |
| abstract_inverted_index.that | 139 |
| abstract_inverted_index.being | 115 |
| abstract_inverted_index.lungs | 53 |
| abstract_inverted_index.other | 68 |
| abstract_inverted_index.since | 15 |
| abstract_inverted_index.solid | 44 |
| abstract_inverted_index.which | 112 |
| abstract_inverted_index.Animal | 0 |
| abstract_inverted_index.almost | 23 |
| abstract_inverted_index.forms. | 45 |
| abstract_inverted_index.humans | 58 |
| abstract_inverted_index.liquid | 42 |
| abstract_inverted_index.modern | 16 |
| abstract_inverted_index.place, | 21 |
| abstract_inverted_index.review | 13 |
| abstract_inverted_index.Inhaled | 73 |
| abstract_inverted_index.Sources | 117 |
| abstract_inverted_index.aerosol | 99 |
| abstract_inverted_index.anatomy | 104 |
| abstract_inverted_index.animals | 39, 56 |
| abstract_inverted_index.because | 61 |
| abstract_inverted_index.between | 71, 120, 146 |
| abstract_inverted_index.include | 122 |
| abstract_inverted_index.process | 14 |
| abstract_inverted_index.product | 8 |
| abstract_inverted_index.scaling | 145 |
| abstract_inverted_index.species | 110, 121 |
| abstract_inverted_index.studies | 1 |
| abstract_inverted_index.system, | 126 |
| abstract_inverted_index.systems | 30 |
| abstract_inverted_index.variety | 27 |
| abstract_inverted_index.aerosols | 35 |
| abstract_inverted_index.century. | 25 |
| abstract_inverted_index.delivery | 37, 75, 125 |
| abstract_inverted_index.factors. | 130 |
| abstract_inverted_index.function | 107 |
| abstract_inverted_index.generate | 34 |
| abstract_inverted_index.genetic, | 63 |
| abstract_inverted_index.requires | 77 |
| abstract_inverted_index.scrutiny | 78 |
| abstract_inverted_index.species. | 72, 147 |
| abstract_inverted_index.available | 32 |
| abstract_inverted_index.behavior, | 82 |
| abstract_inverted_index.component | 5 |
| abstract_inverted_index.deposited | 49 |
| abstract_inverted_index.estimates | 142 |
| abstract_inverted_index.important | 4, 133 |
| abstract_inverted_index.practices | 17 |
| abstract_inverted_index.pulmonary | 106 |
| abstract_inverted_index.variables | 138 |
| abstract_inverted_index.biological | 69, 129 |
| abstract_inverted_index.contribute | 140 |
| abstract_inverted_index.deposition | 88 |
| abstract_inverted_index.evaluated. | 116 |
| abstract_inverted_index.influenced | 90 |
| abstract_inverted_index.laboratory | 55 |
| abstract_inverted_index.properties | 95 |
| abstract_inverted_index.regulatory | 12 |
| abstract_inverted_index.underlying | 137 |
| abstract_inverted_index.acknowledge | 135 |
| abstract_inverted_index.aerodynamic | 81 |
| abstract_inverted_index.anatomical, | 64 |
| abstract_inverted_index.challenging | 60 |
| abstract_inverted_index.development | 9 |
| abstract_inverted_index.differences | 70 |
| abstract_inverted_index.variability | 119 |
| abstract_inverted_index.experimental | 29 |
| abstract_inverted_index.formulation, | 124 |
| abstract_inverted_index.extrapolation | 47, 76 |
| abstract_inverted_index.physiological, | 65 |
| abstract_inverted_index.pharmacological, | 66 |
| abstract_inverted_index.species-specific | 128 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5071846305 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I180297670 |
| citation_normalized_percentile.value | 0.96131319 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |