Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA Nanoparticles Article Swipe
Hanaa H. Ahmed
,
Soheir E. Kotob
,
Ahmed Abdrabou
,
Hadeer A. Aglan
,
Gamal A. Elmegeed
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.13005/bpj/2274
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.13005/bpj/2274
This research aimed to formulate quercetin (Qu) and curcumin (CUR)-loaded PLGA NPs coated with chitosan (CS) & PEG and to explore their therapeutic effect against obesity in rats. Qu and CUR nanostructures were prepared and characterized by Zetasizer and TEM. Then, the formulated nanoparticles and their free couterparts were employed for mitigation of obesity in female rats. The size of NPs was in nanometer range with an average size distribution 307.9 nm for Qu NPs and 322.5 nm for CUR NPs. The Qu NPs and CUR NPs were appeared in the TEM image containing core in which the Qu or CUR was localized and surrounded by the coat of PLGA-CS-PEG. The Qu NPs exhibited negative zeta potential at -8.5 mV, while, CUR NPs exhibited positive zeta potential at +0.916 mV. Treatment with orlistat, free Qu, Qu NPs, free CURor CUR NPs elicited significant decline in body weight, BMI and Lee index. Orlistat and CUR NPs significantly diminished liver, heart and visceral adipose tissue weights. Furthermore, the suggested treatments significantly reduced the gonadal and subcutaneous adipose tissue weights. Orlistat significantly lessened kidney and adrenal weights. All treatments significantly minimized serum Chol., TG, LDL, glucose, INS, HOMA-IR, LH, MDA, TLR4 and NF-κB levels and elevated serum HDL, E2 and TAC levels. Orlistat significantly enhanced serum IL-10 level. Conclusively, Qu and CUR nanoformulations offer anti-obesity potency through their hypolipidemic, hypoglycemic,antioxidative and anti-inflammatory effects. Both Qu and CUR NPs manifested superior effect than their free counterparts, may be because of solubility elevation as well as bioavailability of the nanoencapsulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.13005/bpj/2274
- OA Status
- diamond
- Cited By
- 11
- References
- 179
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4206022213
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4206022213Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.13005/bpj/2274Digital Object Identifier
- Title
-
Pre-Clinical Evidence for the Anti-Obesity Potential of Quercetin and Curcumin Loaded Chitosan/PEG Blended PLGA NanoparticlesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-12-30Full publication date if available
- Authors
-
Hanaa H. Ahmed, Soheir E. Kotob, Ahmed Abdrabou, Hadeer A. Aglan, Gamal A. ElmegeedList of authors in order
- Landing page
-
https://doi.org/10.13005/bpj/2274Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.13005/bpj/2274Direct OA link when available
- Concepts
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Quercetin, Orlistat, Curcumin, Chemistry, Zeta potential, Adipose tissue, PEG ratio, Pharmacology, In vivo, Chitosan, Nanoparticle, Nuclear chemistry, Endocrinology, Antioxidant, Obesity, Biochemistry, Nanotechnology, Medicine, Weight loss, Materials science, Biology, Finance, Biotechnology, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 2, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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179Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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