Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.3390/v15071458
The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug resistance (PDR) patterns, effect of viral clades on PDR, and programmatic implications on first-line regimens in Cameroon. A sentinel surveillance of PDR was conducted from 2014 to 2019. Sequencing of HIV-1 protease and reverse transcriptase was performed, and HIVDR was interpreted using Stanford HIVdb.v.9.4. In total, 379 sequences were obtained from participants (62% female, mean age 36 ± 10 years). The overall PDR rate was 15.0% [95% CI: 11.8–19.0] nationwide, with significant disparity between regions (p = 0.03). NNRTI PDR was highest (12.4%), of which 7.9% had DRMs to EFV/NVP. Two regions had EFV/NVP PDR above the 10% critical threshold, namely the Far North (15%) and East (10.9%). Eighteen viral strains were identified, predominated by CRF02_AG (65.4%), with no influence of genetic diversity PDR occurrence. TDF-3TC-DTG predictive efficacy was superior (98.4%) to TDF-3TC-EFV (92%), p < 0.0001. The overall high rate of PDR in Cameroon, not substantially affected by the wide HIV-1 genetic diversity, underscores the poor efficacy of EFV/NVP-based first-line ART nationwide, with major implications in two regions of the country. This supports the need for a rapid transition to NNRTI-sparing regimens, with TDF-3TC-DTG having optimal efficacy at the programmatic level.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v15071458
- https://www.mdpi.com/1999-4915/15/7/1458/pdf?version=1687929955
- OA Status
- gold
- Cited By
- 12
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382403327
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4382403327Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v15071458Digital Object Identifier
- Title
-
Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line RegimensWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-06-28Full publication date if available
- Authors
-
Joseph Fokam, Collins Ambe Chenwi, Valère Tala, Désiré Takou, Maria Mercedes Santoro, G. Teto, Béatrice Dambaya, Felix Anubodem, Ezéchiel Ngoufack Jagni Semengue, Grâce Beloumou, Sandrine Djupsa, Edgar Assomo, Charles Fokunang, Claudia Alteri, Serge Clotaire Billong, Nounouce Pamen Bouba, Rogers Ajeh, Vittorio Colizzi, Dora Mbanya, Francesca Ceccherini‐Silberstein, Carlo Federico Perno, Alexis NdjoloList of authors in order
- Landing page
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https://doi.org/10.3390/v15071458Publisher landing page
- PDF URL
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https://www.mdpi.com/1999-4915/15/7/1458/pdf?version=1687929955Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/15/7/1458/pdf?version=1687929955Direct OA link when available
- Concepts
-
HIV drug resistance, Drug resistance, Human immunodeficiency virus (HIV), Genetic diversity, Antiretroviral therapy, Viral load, Virology, Medicine, Internal medicine, Biology, Microbiology, Environmental health, PopulationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 8, 2024: 4Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.East | 129 |
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| abstract_inverted_index.rate | 86, 163 |
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| abstract_inverted_index.(PDR) | 24 |
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| abstract_inverted_index.0.03). | 100 |
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| abstract_inverted_index.(65.4%), | 139 |
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| corresponding_author_ids | https://openalex.org/A5084242627, https://openalex.org/A5078478462 |
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| institutions_distinct_count | 22 |
| corresponding_institution_ids | https://openalex.org/I116067653, https://openalex.org/I1331070479, https://openalex.org/I144693123, https://openalex.org/I4210091290, https://openalex.org/I4210137632 |
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