Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathway Article Swipe
Marcia Morita‐Sherman
,
Eugen Trinka
,
Patrick Kwan
,
Akio Ikeda
,
Min Cho
,
Harald Hampel
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2025.1644835
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2025.1644835
Epilepsies are a common, but heterogeneous group of brain disorders, characterized by an enduring predisposition to recurrent epileptic seizures. Recognizing epilepsies as a disease spectrum offers compelling opportunities to implement precision medicine in routine care. In this narrative review, we assess the status and development of precision epilepsy, compare its implementation with the advanced model of precision oncology, and discuss strategies to advance the implementation of precision medicine in epilepsy care. We aim to raise awareness about the current state-of-the-art approaches in precision epilepsy, emphasizing their potential to optimize epilepsy care. Rapid technological innovations provide the foundation to improve epilepsy research and management including the establishment of multi-dimensional biomarkers to aid disease subtyping and treatment decision. We also introduce emerging digital health technologies that will transform seizure monitoring and prediction. Advances in data science and artificial intelligence will deepen our knowledge of epilepsies, and may deconstruct and systematize historical, clinical, and descriptive concepts. Following a thorough examination of the current epilepsy landscape – including obstacles against precision medicine implementation and clinical adoption - we envision that the path toward precision epilepsy care lies in studies uncovering the mechanisms underlying systems-biology and neurophysiology-based epileptogenesis using technological innovations, such as genetic testing, fluid indicators, neuroimaging, neurophysiology, and wearable devices. We review the literature based on four core pillars - biomarkers, digital technologies, systems medicine, and data science - to pinpoint the unmet need for epilepsies and thus revolutionize disease management strategies.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2025.1644835
- https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdf
- OA Status
- gold
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414138365
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4414138365Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fneur.2025.1644835Digital Object Identifier
- Title
-
Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathwayWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-11Full publication date if available
- Authors
-
Marcia Morita‐Sherman, Eugen Trinka, Patrick Kwan, Akio Ikeda, Min Cho, Harald HampelList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2025.1644835Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
85Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4414138365 |
|---|---|
| doi | https://doi.org/10.3389/fneur.2025.1644835 |
| ids.doi | https://doi.org/10.3389/fneur.2025.1644835 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41018203 |
| ids.openalex | https://openalex.org/W4414138365 |
| fwci | 0.0 |
| type | review |
| title | Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathway |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1644835 |
| biblio.first_page | 1644835 |
| topics[0].id | https://openalex.org/T10094 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2738 |
| topics[0].subfield.display_name | Psychiatry and Mental health |
| topics[0].display_name | Epilepsy research and treatment |
| topics[1].id | https://openalex.org/T11642 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1311 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Genomics and Rare Diseases |
| topics[2].id | https://openalex.org/T12267 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9955999851226807 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2737 |
| topics[2].subfield.display_name | Physiology |
| topics[2].display_name | Diet and metabolism studies |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| language | en |
| locations[0].id | doi:10.3389/fneur.2025.1644835 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S96975567 |
| locations[0].source.issn | 1664-2295 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-2295 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Neurology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Neurology |
| locations[0].landing_page_url | https://doi.org/10.3389/fneur.2025.1644835 |
| locations[1].id | pmid:41018203 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in neurology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41018203 |
| locations[2].id | pmh:oai:doaj.org/article:6e7a7c1ea6c64f1496ba95b7b93343b2 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Neurology, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/6e7a7c1ea6c64f1496ba95b7b93343b2 |
| locations[3].id | pmh:oai:europepmc.org:11268834 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12460136 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5072150609 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8531-3916 |
| authorships[0].author.display_name | Marcia Morita‐Sherman |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210151718 |
| authorships[0].affiliations[0].raw_affiliation_string | Eisai Inc., Nutley, NJ, United States |
| authorships[0].institutions[0].id | https://openalex.org/I4210151718 |
| authorships[0].institutions[0].ror | https://ror.org/0469x1750 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210151718, https://openalex.org/I55881946 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Eisai (United States) |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Marcia Morita-Sherman |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Eisai Inc., Nutley, NJ, United States |
| authorships[1].author.id | https://openalex.org/A5076045134 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5950-2692 |
| authorships[1].author.display_name | Eugen Trinka |
| authorships[1].countries | AT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I27945538 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neurology, Neurointensive Care, and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Member of EpiCARE, Salzburg, Austria |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I4210106988 |
| authorships[1].affiliations[1].raw_affiliation_string | Neuroscience Institute, Center for Cognitive Neuroscience, Christian Doppler University Hospital, Salzburg, Austria |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I4210161345 |
| authorships[1].affiliations[2].raw_affiliation_string | Karl Landsteiner Institute for Clinical Neurosciences, Salzburg, Austria |
| authorships[1].institutions[0].id | https://openalex.org/I4210106988 |
| authorships[1].institutions[0].ror | https://ror.org/01fpkt395 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210106988 |
| authorships[1].institutions[0].country_code | AT |
| authorships[1].institutions[0].display_name | Christian Doppler Klinik |
| authorships[1].institutions[1].id | https://openalex.org/I4210161345 |
| authorships[1].institutions[1].ror | https://ror.org/05r0e4p82 |
| authorships[1].institutions[1].type | other |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210161345 |
| authorships[1].institutions[1].country_code | AT |
| authorships[1].institutions[1].display_name | Karl Landsteiner Society |
| authorships[1].institutions[2].id | https://openalex.org/I27945538 |
| authorships[1].institutions[2].ror | https://ror.org/03z3mg085 |
| authorships[1].institutions[2].type | education |
| authorships[1].institutions[2].lineage | https://openalex.org/I27945538 |
| authorships[1].institutions[2].country_code | AT |
| authorships[1].institutions[2].display_name | Paracelsus Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Eugen Trinka |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neurology, Neurointensive Care, and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University, Member of EpiCARE, Salzburg, Austria, Karl Landsteiner Institute for Clinical Neurosciences, Salzburg, Austria, Neuroscience Institute, Center for Cognitive Neuroscience, Christian Doppler University Hospital, Salzburg, Austria |
| authorships[2].author.id | https://openalex.org/A5067443324 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7310-276X |
| authorships[2].author.display_name | Patrick Kwan |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210163178 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurology, Alfred Health, Melbourne, VIC, Australia |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I1320473756, https://openalex.org/I165779595 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I56590836 |
| authorships[2].affiliations[2].raw_affiliation_string | Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia |
| authorships[2].institutions[0].id | https://openalex.org/I4210163178 |
| authorships[2].institutions[0].ror | https://ror.org/04scfb908 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210163178 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | Alfred Health |
| authorships[2].institutions[1].id | https://openalex.org/I56590836 |
| authorships[2].institutions[1].ror | https://ror.org/02bfwt286 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I56590836 |
| authorships[2].institutions[1].country_code | AU |
| authorships[2].institutions[1].display_name | Monash University |
| authorships[2].institutions[2].id | https://openalex.org/I1320473756 |
| authorships[2].institutions[2].ror | https://ror.org/005bvs909 |
| authorships[2].institutions[2].type | healthcare |
| authorships[2].institutions[2].lineage | https://openalex.org/I1320473756, https://openalex.org/I4210158168 |
| authorships[2].institutions[2].country_code | AU |
| authorships[2].institutions[2].display_name | The Royal Melbourne Hospital |
| authorships[2].institutions[3].id | https://openalex.org/I165779595 |
| authorships[2].institutions[3].ror | https://ror.org/01ej9dk98 |
| authorships[2].institutions[3].type | education |
| authorships[2].institutions[3].lineage | https://openalex.org/I165779595 |
| authorships[2].institutions[3].country_code | AU |
| authorships[2].institutions[3].display_name | The University of Melbourne |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Patrick Kwan |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurology, Alfred Health, Melbourne, VIC, Australia, Department of Neurology, Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia, Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia |
| authorships[3].author.id | https://openalex.org/A5069265637 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0790-2598 |
| authorships[3].author.display_name | Akio Ikeda |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I22299242 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Epilepsy, Movement Disorders and Physiology Kyoto University Graduate School of Medicine Shogoin, Kyoto, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I22299242 |
| authorships[3].institutions[0].ror | https://ror.org/02kpeqv85 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I22299242 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Kyoto University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Akio Ikeda |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Epilepsy, Movement Disorders and Physiology Kyoto University Graduate School of Medicine Shogoin, Kyoto, Japan |
| authorships[4].author.id | https://openalex.org/A5045518493 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-4696-0173 |
| authorships[4].author.display_name | Min Cho |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210151718 |
| authorships[4].affiliations[0].raw_affiliation_string | Eisai Inc., Nutley, NJ, United States |
| authorships[4].institutions[0].id | https://openalex.org/I4210151718 |
| authorships[4].institutions[0].ror | https://ror.org/0469x1750 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210151718, https://openalex.org/I55881946 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Eisai (United States) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Min Cho |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Eisai Inc., Nutley, NJ, United States |
| authorships[5].author.id | https://openalex.org/A5037109052 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0894-8982 |
| authorships[5].author.display_name | Harald Hampel |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210151718 |
| authorships[5].affiliations[0].raw_affiliation_string | Eisai Inc., Nutley, NJ, United States |
| authorships[5].institutions[0].id | https://openalex.org/I4210151718 |
| authorships[5].institutions[0].ror | https://ror.org/0469x1750 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210151718, https://openalex.org/I55881946 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Eisai (United States) |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Harald Hampel |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Eisai Inc., Nutley, NJ, United States |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Precision medicine for epilepsy: challenges and perspectives for an optimized clinical care pathway |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10094 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2738 |
| primary_topic.subfield.display_name | Psychiatry and Mental health |
| primary_topic.display_name | Epilepsy research and treatment |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W3108674512, https://openalex.org/W1506200166 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fneur.2025.1644835 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S96975567 |
| best_oa_location.source.issn | 1664-2295 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-2295 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Neurology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Neurology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fneur.2025.1644835 |
| primary_location.id | doi:10.3389/fneur.2025.1644835 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S96975567 |
| primary_location.source.issn | 1664-2295 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-2295 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Neurology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1644835/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Neurology |
| primary_location.landing_page_url | https://doi.org/10.3389/fneur.2025.1644835 |
| publication_date | 2025-09-11 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W1978437325, https://openalex.org/W3157419554, https://openalex.org/W4364378540, https://openalex.org/W3177289043, https://openalex.org/W2038888907, https://openalex.org/W4391754373, https://openalex.org/W3172791707, https://openalex.org/W4211147755, https://openalex.org/W2965355603, https://openalex.org/W4407981971, https://openalex.org/W3092129232, https://openalex.org/W3130702037, https://openalex.org/W3098363273, https://openalex.org/W2060427373, https://openalex.org/W2748267505, https://openalex.org/W2227079180, https://openalex.org/W4315871740, https://openalex.org/W2773309042, https://openalex.org/W2963414887, https://openalex.org/W4368361301, https://openalex.org/W4320033918, https://openalex.org/W4306664926, https://openalex.org/W2765754703, https://openalex.org/W4292263691, https://openalex.org/W3179061525, https://openalex.org/W4291019249, https://openalex.org/W4387101868, https://openalex.org/W3035511928, https://openalex.org/W4225248989, https://openalex.org/W1506837790, https://openalex.org/W3019362658, https://openalex.org/W3000036802, https://openalex.org/W3000653518, https://openalex.org/W2020336128, https://openalex.org/W2073057919, https://openalex.org/W3196201435, https://openalex.org/W2792752177, https://openalex.org/W4282962604, https://openalex.org/W4408544011, https://openalex.org/W4319661528, https://openalex.org/W2326415576, https://openalex.org/W3199572846, https://openalex.org/W4391707247, https://openalex.org/W3004542520, https://openalex.org/W4410039029, https://openalex.org/W4297802295, https://openalex.org/W3045329727, https://openalex.org/W3023664471, https://openalex.org/W3198627257, https://openalex.org/W4200207316, https://openalex.org/W4298122295, https://openalex.org/W2562561808, https://openalex.org/W3217226680, https://openalex.org/W4385630444, https://openalex.org/W4205617866, https://openalex.org/W3179475981, https://openalex.org/W3133716463, https://openalex.org/W2276567012, https://openalex.org/W2120853742, https://openalex.org/W4280516165, https://openalex.org/W2162142051, https://openalex.org/W2945704071, https://openalex.org/W2611138580, https://openalex.org/W4367186564, https://openalex.org/W4291398401, https://openalex.org/W3179683710, https://openalex.org/W3103554383, https://openalex.org/W3195935404, https://openalex.org/W3012009865, https://openalex.org/W3197896347, https://openalex.org/W4293458356, https://openalex.org/W4297989470, https://openalex.org/W4293413307, https://openalex.org/W2961058847, https://openalex.org/W2968494487, https://openalex.org/W4307930851, https://openalex.org/W2617669016, https://openalex.org/W3160746195, https://openalex.org/W3012501605, https://openalex.org/W2594644573, https://openalex.org/W2592509339, https://openalex.org/W3200322762, https://openalex.org/W2033760933, https://openalex.org/W4200609332, https://openalex.org/W3086590218 |
| referenced_works_count | 85 |
| abstract_inverted_index.- | 172, 216, 225 |
| abstract_inverted_index.a | 2, 22, 154 |
| abstract_inverted_index.In | 35 |
| abstract_inverted_index.We | 71, 116, 207 |
| abstract_inverted_index.an | 12 |
| abstract_inverted_index.as | 21, 197 |
| abstract_inverted_index.by | 11 |
| abstract_inverted_index.in | 32, 68, 81, 131, 183 |
| abstract_inverted_index.of | 7, 45, 55, 65, 106, 141, 157 |
| abstract_inverted_index.on | 212 |
| abstract_inverted_index.to | 15, 28, 61, 73, 87, 97, 109, 226 |
| abstract_inverted_index.we | 39, 173 |
| abstract_inverted_index.aid | 110 |
| abstract_inverted_index.aim | 72 |
| abstract_inverted_index.and | 43, 58, 101, 113, 128, 134, 143, 146, 150, 169, 190, 204, 222, 233 |
| abstract_inverted_index.are | 1 |
| abstract_inverted_index.but | 4 |
| abstract_inverted_index.for | 231 |
| abstract_inverted_index.its | 49 |
| abstract_inverted_index.may | 144 |
| abstract_inverted_index.our | 139 |
| abstract_inverted_index.the | 41, 52, 63, 77, 95, 104, 158, 176, 186, 209, 228 |
| abstract_inverted_index.– | 162 |
| abstract_inverted_index.also | 117 |
| abstract_inverted_index.care | 181 |
| abstract_inverted_index.core | 214 |
| abstract_inverted_index.data | 132, 223 |
| abstract_inverted_index.four | 213 |
| abstract_inverted_index.lies | 182 |
| abstract_inverted_index.need | 230 |
| abstract_inverted_index.path | 177 |
| abstract_inverted_index.such | 196 |
| abstract_inverted_index.that | 123, 175 |
| abstract_inverted_index.this | 36 |
| abstract_inverted_index.thus | 234 |
| abstract_inverted_index.will | 124, 137 |
| abstract_inverted_index.with | 51 |
| abstract_inverted_index.Rapid | 91 |
| abstract_inverted_index.about | 76 |
| abstract_inverted_index.based | 211 |
| abstract_inverted_index.brain | 8 |
| abstract_inverted_index.care. | 34, 70, 90 |
| abstract_inverted_index.fluid | 200 |
| abstract_inverted_index.group | 6 |
| abstract_inverted_index.model | 54 |
| abstract_inverted_index.raise | 74 |
| abstract_inverted_index.their | 85 |
| abstract_inverted_index.unmet | 229 |
| abstract_inverted_index.using | 193 |
| abstract_inverted_index.assess | 40 |
| abstract_inverted_index.deepen | 138 |
| abstract_inverted_index.health | 121 |
| abstract_inverted_index.offers | 25 |
| abstract_inverted_index.review | 208 |
| abstract_inverted_index.status | 42 |
| abstract_inverted_index.toward | 178 |
| abstract_inverted_index.advance | 62 |
| abstract_inverted_index.against | 165 |
| abstract_inverted_index.common, | 3 |
| abstract_inverted_index.compare | 48 |
| abstract_inverted_index.current | 78, 159 |
| abstract_inverted_index.digital | 120, 218 |
| abstract_inverted_index.discuss | 59 |
| abstract_inverted_index.disease | 23, 111, 236 |
| abstract_inverted_index.genetic | 198 |
| abstract_inverted_index.improve | 98 |
| abstract_inverted_index.pillars | 215 |
| abstract_inverted_index.provide | 94 |
| abstract_inverted_index.review, | 38 |
| abstract_inverted_index.routine | 33 |
| abstract_inverted_index.science | 133, 224 |
| abstract_inverted_index.seizure | 126 |
| abstract_inverted_index.studies | 184 |
| abstract_inverted_index.systems | 220 |
| abstract_inverted_index.Advances | 130 |
| abstract_inverted_index.adoption | 171 |
| abstract_inverted_index.advanced | 53 |
| abstract_inverted_index.clinical | 170 |
| abstract_inverted_index.devices. | 206 |
| abstract_inverted_index.emerging | 119 |
| abstract_inverted_index.enduring | 13 |
| abstract_inverted_index.envision | 174 |
| abstract_inverted_index.epilepsy | 69, 89, 99, 160, 180 |
| abstract_inverted_index.medicine | 31, 67, 167 |
| abstract_inverted_index.optimize | 88 |
| abstract_inverted_index.pinpoint | 227 |
| abstract_inverted_index.research | 100 |
| abstract_inverted_index.spectrum | 24 |
| abstract_inverted_index.testing, | 199 |
| abstract_inverted_index.thorough | 155 |
| abstract_inverted_index.wearable | 205 |
| abstract_inverted_index.Following | 153 |
| abstract_inverted_index.awareness | 75 |
| abstract_inverted_index.clinical, | 149 |
| abstract_inverted_index.concepts. | 152 |
| abstract_inverted_index.decision. | 115 |
| abstract_inverted_index.epilepsy, | 47, 83 |
| abstract_inverted_index.epileptic | 17 |
| abstract_inverted_index.implement | 29 |
| abstract_inverted_index.including | 103, 163 |
| abstract_inverted_index.introduce | 118 |
| abstract_inverted_index.knowledge | 140 |
| abstract_inverted_index.landscape | 161 |
| abstract_inverted_index.medicine, | 221 |
| abstract_inverted_index.narrative | 37 |
| abstract_inverted_index.obstacles | 164 |
| abstract_inverted_index.oncology, | 57 |
| abstract_inverted_index.potential | 86 |
| abstract_inverted_index.precision | 30, 46, 56, 66, 82, 166, 179 |
| abstract_inverted_index.recurrent | 16 |
| abstract_inverted_index.seizures. | 18 |
| abstract_inverted_index.subtyping | 112 |
| abstract_inverted_index.transform | 125 |
| abstract_inverted_index.treatment | 114 |
| abstract_inverted_index.Epilepsies | 0 |
| abstract_inverted_index.approaches | 80 |
| abstract_inverted_index.artificial | 135 |
| abstract_inverted_index.biomarkers | 108 |
| abstract_inverted_index.compelling | 26 |
| abstract_inverted_index.disorders, | 9 |
| abstract_inverted_index.epilepsies | 20, 232 |
| abstract_inverted_index.foundation | 96 |
| abstract_inverted_index.literature | 210 |
| abstract_inverted_index.management | 102, 237 |
| abstract_inverted_index.mechanisms | 187 |
| abstract_inverted_index.monitoring | 127 |
| abstract_inverted_index.strategies | 60 |
| abstract_inverted_index.uncovering | 185 |
| abstract_inverted_index.underlying | 188 |
| abstract_inverted_index.Recognizing | 19 |
| abstract_inverted_index.biomarkers, | 217 |
| abstract_inverted_index.deconstruct | 145 |
| abstract_inverted_index.descriptive | 151 |
| abstract_inverted_index.development | 44 |
| abstract_inverted_index.emphasizing | 84 |
| abstract_inverted_index.epilepsies, | 142 |
| abstract_inverted_index.examination | 156 |
| abstract_inverted_index.historical, | 148 |
| abstract_inverted_index.indicators, | 201 |
| abstract_inverted_index.innovations | 93 |
| abstract_inverted_index.prediction. | 129 |
| abstract_inverted_index.strategies. | 238 |
| abstract_inverted_index.systematize | 147 |
| abstract_inverted_index.innovations, | 195 |
| abstract_inverted_index.intelligence | 136 |
| abstract_inverted_index.technologies | 122 |
| abstract_inverted_index.characterized | 10 |
| abstract_inverted_index.establishment | 105 |
| abstract_inverted_index.heterogeneous | 5 |
| abstract_inverted_index.neuroimaging, | 202 |
| abstract_inverted_index.opportunities | 27 |
| abstract_inverted_index.revolutionize | 235 |
| abstract_inverted_index.technological | 92, 194 |
| abstract_inverted_index.technologies, | 219 |
| abstract_inverted_index.implementation | 50, 64, 168 |
| abstract_inverted_index.predisposition | 14 |
| abstract_inverted_index.epileptogenesis | 192 |
| abstract_inverted_index.systems-biology | 189 |
| abstract_inverted_index.neurophysiology, | 203 |
| abstract_inverted_index.state-of-the-art | 79 |
| abstract_inverted_index.multi-dimensional | 107 |
| abstract_inverted_index.neurophysiology-based | 191 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5037109052 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I4210151718 |
| citation_normalized_percentile.value | 0.49842648 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |