Predatory Strategies of Myxococcus xanthus: Prey Susceptibility to OMVs and Moonlighting Enzymes Article Swipe
Allison S. Zwarycz
,
Thomas Page
,
Gabriela Nikolova
,
Emily Jade Radford
,
David E. Whitworth
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms11040874
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/microorganisms11040874
Predatory outer membrane vesicles (OMVs) secreted by myxobacteria fuse readily with the outer membranes of Gram-negative bacteria, introducing toxic cargo into their prey. Here we used a strain of the myxobacterium Myxococcus xanthus that produces fluorescent OMVs to assay the uptake of OMVs by a panel of Gram-negative bacteria. M. xanthus strains took up significantly less OMV material than the tested prey strains, suggesting that re-fusion of OMVs with producing organisms is somehow inhibited. The OMV killing activity against different prey correlated strongly with the predatory activity of myxobacterial cells, however, there was no correlation between OMV killing activity and their propensity to fuse with different prey. It has previously been proposed that M. xanthus GAPDH stimulates the predatory activity of OMVs by enhancing OMV fusion with prey cells. Therefore, we expressed and purified active fusion proteins of M. xanthus glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase (GAPDH and PGK; moonlighting enzymes with additional activities beyond their roles in glycolysis/gluconeogenesis) to investigate any involvement in OMV-mediated predation. Neither GAPDH nor PGK caused lysis of prey cells or enhanced OMV-mediated lysis of prey cells. However, both enzymes were found to inhibit the growth of Escherichia coli, even in the absence of OMVs. Our results suggest that fusion efficiency is not a determinant of prey killing, but instead resistance to the cargo of OMVs and co-secreted enzymes dictates whether organisms can be preyed upon by myxobacteria.
Related Topics
Concepts
Myxococcus xanthus
Biology
Myxobacteria
Microbiology
Bacterial outer membrane
Bacteria
Enzyme
Biochemistry
Cell biology
Escherichia coli
Mutant
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/microorganisms11040874
- https://www.mdpi.com/2076-2607/11/4/874/pdf?version=1680065914
- OA Status
- gold
- Cited By
- 12
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4361291522
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4361291522Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/microorganisms11040874Digital Object Identifier
- Title
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Predatory Strategies of Myxococcus xanthus: Prey Susceptibility to OMVs and Moonlighting EnzymesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-29Full publication date if available
- Authors
-
Allison S. Zwarycz, Thomas Page, Gabriela Nikolova, Emily Jade Radford, David E. WhitworthList of authors in order
- Landing page
-
https://doi.org/10.3390/microorganisms11040874Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-2607/11/4/874/pdf?version=1680065914Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-2607/11/4/874/pdf?version=1680065914Direct OA link when available
- Concepts
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Myxococcus xanthus, Biology, Myxobacteria, Microbiology, Bacterial outer membrane, Bacteria, Enzyme, Biochemistry, Cell biology, Escherichia coli, Mutant, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 5, 2023: 4Per-year citation counts (last 5 years)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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