Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression Article Swipe
Ali Afgar
,
Sattarzadeh Bardsiri Mahla
,
Reza Vahidi
,
Alireza Farsinejad
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1515/jib-2021-0016
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1515/jib-2021-0016
Aberrant expression of genes involved in methylation, including DNA methyltransferase 3 Beta ( DNMT3B ), can cause hypermethylation of various tumor suppressor genes. In this regard, various molecular factors such as microRNAs can play a critical role in regulating these methyltransferase enzymes and eventually downstream genes such as growth arrest specific 7 ( GAS7 ). Accordingly, in the present study we aimed to predict regulatory effect of miRNAs on DNMT3B and GAS7 genes expression in melanoma cell line. hsa-miR-203a-3p and hsa-miR-29a-3p were predicted and selected using bioinformatics software. The Real-time PCR technique was performed to investigate the regulatory effect of these molecules on the DNMT3B and GAS7 genes expression. Expression analysis of DNMT3B gene in A375 cell line showed that there was a significant increase compared to control ( p value = 0.0015). Analysis of hsa-miR-203a-3p and hsa-miR-29a-3p indicated the insignificant decreased expression in melanoma cell line compared to control ( p value < 0.05). Compared to control, the expression of GAS7 gene in melanoma cells showed a significant decrease ( p value = 0.0323). Finally, our findings showed that the decreased expression of hsa-miR-203a-3p and hsa-miR-29a-3p can hypothesize that their aberrant expression caused DNMT3B dysfunction, possible methylation of the GAS7 gene, and ultimately decreased its expression. However, complementary studies are necessary to definite comment.
Related Topics
Concepts
DNMT3B
microRNA
DNA methylation
Gene
Gene expression
Biology
Methylation
EGR1
Regulation of gene expression
Molecular biology
Cancer research
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/jib-2021-0016
- https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdf
- OA Status
- diamond
- Cited By
- 3
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200412600
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4200412600Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1515/jib-2021-0016Digital Object Identifier
- Title
-
Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expressionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-16Full publication date if available
- Authors
-
Ali Afgar, Sattarzadeh Bardsiri Mahla, Reza Vahidi, Alireza FarsinejadList of authors in order
- Landing page
-
https://doi.org/10.1515/jib-2021-0016Publisher landing page
- PDF URL
-
https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdfDirect OA link when available
- Concepts
-
DNMT3B, microRNA, DNA methylation, Gene, Gene expression, Biology, Methylation, EGR1, Regulation of gene expression, Molecular biology, Cancer research, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4200412600 |
|---|---|
| doi | https://doi.org/10.1515/jib-2021-0016 |
| ids.doi | https://doi.org/10.1515/jib-2021-0016 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34914337 |
| ids.openalex | https://openalex.org/W4200412600 |
| fwci | 0.29259728 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D019295 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Computational Biology |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D019175 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | DNA Methylation |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D015972 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D035683 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | MicroRNAs |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D035683 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | MicroRNAs |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D019295 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Computational Biology |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D019175 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | DNA Methylation |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D015972 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D035683 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | MicroRNAs |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D035683 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | MicroRNAs |
| type | article |
| title | Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression |
| biblio.issue | 1 |
| biblio.volume | 19 |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10269 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9958999752998352 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Epigenetics and DNA Methylation |
| topics[1].id | https://openalex.org/T10062 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.992900013923645 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1306 |
| topics[1].subfield.display_name | Cancer Research |
| topics[1].display_name | MicroRNA in disease regulation |
| topics[2].id | https://openalex.org/T13157 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9750999808311462 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Cancer-related gene regulation |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2777142704 |
| concepts[0].level | 5 |
| concepts[0].score | 0.7406822443008423 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q15313456 |
| concepts[0].display_name | DNMT3B |
| concepts[1].id | https://openalex.org/C145059251 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6485939621925354 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q310899 |
| concepts[1].display_name | microRNA |
| concepts[2].id | https://openalex.org/C190727270 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6177558898925781 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q874745 |
| concepts[2].display_name | DNA methylation |
| concepts[3].id | https://openalex.org/C104317684 |
| concepts[3].level | 2 |
| concepts[3].score | 0.584225058555603 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[3].display_name | Gene |
| concepts[4].id | https://openalex.org/C150194340 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5444920063018799 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[4].display_name | Gene expression |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5017492771148682 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C33288867 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4900580644607544 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q518328 |
| concepts[6].display_name | Methylation |
| concepts[7].id | https://openalex.org/C2780600689 |
| concepts[7].level | 4 |
| concepts[7].score | 0.46589624881744385 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q14864821 |
| concepts[7].display_name | EGR1 |
| concepts[8].id | https://openalex.org/C165864922 |
| concepts[8].level | 3 |
| concepts[8].score | 0.46302974224090576 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q411391 |
| concepts[8].display_name | Regulation of gene expression |
| concepts[9].id | https://openalex.org/C153911025 |
| concepts[9].level | 1 |
| concepts[9].score | 0.4401721954345703 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[9].display_name | Molecular biology |
| concepts[10].id | https://openalex.org/C502942594 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3874119222164154 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[10].display_name | Cancer research |
| concepts[11].id | https://openalex.org/C54355233 |
| concepts[11].level | 1 |
| concepts[11].score | 0.32587766647338867 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[11].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/dnmt3b |
| keywords[0].score | 0.7406822443008423 |
| keywords[0].display_name | DNMT3B |
| keywords[1].id | https://openalex.org/keywords/microrna |
| keywords[1].score | 0.6485939621925354 |
| keywords[1].display_name | microRNA |
| keywords[2].id | https://openalex.org/keywords/dna-methylation |
| keywords[2].score | 0.6177558898925781 |
| keywords[2].display_name | DNA methylation |
| keywords[3].id | https://openalex.org/keywords/gene |
| keywords[3].score | 0.584225058555603 |
| keywords[3].display_name | Gene |
| keywords[4].id | https://openalex.org/keywords/gene-expression |
| keywords[4].score | 0.5444920063018799 |
| keywords[4].display_name | Gene expression |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.5017492771148682 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/methylation |
| keywords[6].score | 0.4900580644607544 |
| keywords[6].display_name | Methylation |
| keywords[7].id | https://openalex.org/keywords/egr1 |
| keywords[7].score | 0.46589624881744385 |
| keywords[7].display_name | EGR1 |
| keywords[8].id | https://openalex.org/keywords/regulation-of-gene-expression |
| keywords[8].score | 0.46302974224090576 |
| keywords[8].display_name | Regulation of gene expression |
| keywords[9].id | https://openalex.org/keywords/molecular-biology |
| keywords[9].score | 0.4401721954345703 |
| keywords[9].display_name | Molecular biology |
| keywords[10].id | https://openalex.org/keywords/cancer-research |
| keywords[10].score | 0.3874119222164154 |
| keywords[10].display_name | Cancer research |
| keywords[11].id | https://openalex.org/keywords/genetics |
| keywords[11].score | 0.32587766647338867 |
| keywords[11].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.1515/jib-2021-0016 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4393917359 |
| locations[0].source.issn | 1432-4385, 1613-4516 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1432-4385 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].source.host_organization_lineage | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Integrative Bioinformatics |
| locations[0].landing_page_url | https://doi.org/10.1515/jib-2021-0016 |
| locations[1].id | pmid:34914337 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of integrative bioinformatics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34914337 |
| locations[2].id | pmh:oai:doaj.org/article:4bf562def10a40c784bac4372f4771a1 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Integrative Bioinformatics, Vol 19, Iss 1, Pp 112-11 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/4bf562def10a40c784bac4372f4771a1 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9069646 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | J Integr Bioinform |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9069646 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5057060526 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4487-8523 |
| authorships[0].author.display_name | Ali Afgar |
| authorships[0].countries | IR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I235686326 |
| authorships[0].affiliations[0].raw_affiliation_string | Research Center for Hydatid Disease in Iran , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[0].institutions[0].id | https://openalex.org/I235686326 |
| authorships[0].institutions[0].ror | https://ror.org/02kxbqc24 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I235686326 |
| authorships[0].institutions[0].country_code | IR |
| authorships[0].institutions[0].display_name | Kerman University of Medical Sciences |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Afgar Ali |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Research Center for Hydatid Disease in Iran , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[1].author.id | https://openalex.org/A5067871059 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Sattarzadeh Bardsiri Mahla |
| authorships[1].countries | IR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I235686326 |
| authorships[1].affiliations[0].raw_affiliation_string | Student Research Committee, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I235686326 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I235686326 |
| authorships[1].affiliations[2].raw_affiliation_string | Cell Therapy and Regenerative Medicine Comprehensive Center , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[1].institutions[0].id | https://openalex.org/I235686326 |
| authorships[1].institutions[0].ror | https://ror.org/02kxbqc24 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I235686326 |
| authorships[1].institutions[0].country_code | IR |
| authorships[1].institutions[0].display_name | Kerman University of Medical Sciences |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sattarzadeh Bardsiri Mahla |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Cell Therapy and Regenerative Medicine Comprehensive Center , Kerman University of Medical Sciences , Kerman , Iran, Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran, Student Research Committee, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[2].author.id | https://openalex.org/A5044315342 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8990-289X |
| authorships[2].author.display_name | Reza Vahidi |
| authorships[2].countries | IR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I235686326 |
| authorships[2].affiliations[0].raw_affiliation_string | Research Center for Hydatid Disease in Iran , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[2].institutions[0].id | https://openalex.org/I235686326 |
| authorships[2].institutions[0].ror | https://ror.org/02kxbqc24 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I235686326 |
| authorships[2].institutions[0].country_code | IR |
| authorships[2].institutions[0].display_name | Kerman University of Medical Sciences |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Vahidi Reza |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Research Center for Hydatid Disease in Iran , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[3].author.id | https://openalex.org/A5003661933 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0276-6881 |
| authorships[3].author.display_name | Alireza Farsinejad |
| authorships[3].countries | IR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I235686326 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I235686326 |
| authorships[3].affiliations[1].raw_affiliation_string | Cell Therapy and Regenerative Medicine Comprehensive Center , Kerman University of Medical Sciences , Kerman , Iran |
| authorships[3].institutions[0].id | https://openalex.org/I235686326 |
| authorships[3].institutions[0].ror | https://ror.org/02kxbqc24 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I235686326 |
| authorships[3].institutions[0].country_code | IR |
| authorships[3].institutions[0].display_name | Kerman University of Medical Sciences |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Farsinejad Alireza |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Cell Therapy and Regenerative Medicine Comprehensive Center , Kerman University of Medical Sciences , Kerman , Iran, Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine , Kerman University of Medical Sciences , Kerman , Iran |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2021-12-31T00:00:00 |
| display_name | Predicting the possible effect of miR-203a-3p and miR-29a-3p on DNMT3B and GAS7 genes expression |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10269 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9958999752998352 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Epigenetics and DNA Methylation |
| related_works | https://openalex.org/W2902329290, https://openalex.org/W2052355316, https://openalex.org/W2046964473, https://openalex.org/W2107880877, https://openalex.org/W2151182744, https://openalex.org/W2024490794, https://openalex.org/W2221018455, https://openalex.org/W2054863651, https://openalex.org/W1998349112, https://openalex.org/W2775119606 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1515/jib-2021-0016 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4393917359 |
| best_oa_location.source.issn | 1432-4385, 1613-4516 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1432-4385 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.source.host_organization_lineage | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Integrative Bioinformatics |
| best_oa_location.landing_page_url | https://doi.org/10.1515/jib-2021-0016 |
| primary_location.id | doi:10.1515/jib-2021-0016 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4393917359 |
| primary_location.source.issn | 1432-4385, 1613-4516 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1432-4385 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.source.host_organization_lineage | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.degruyter.com/document/doi/10.1515/jib-2021-0016/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Integrative Bioinformatics |
| primary_location.landing_page_url | https://doi.org/10.1515/jib-2021-0016 |
| publication_date | 2021-12-16 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2154683287, https://openalex.org/W1881660869, https://openalex.org/W4211020617, https://openalex.org/W2130330090, https://openalex.org/W4255367584, https://openalex.org/W2009121506, https://openalex.org/W2605077517, https://openalex.org/W2060446375, https://openalex.org/W2279047507, https://openalex.org/W2192681205, https://openalex.org/W2159325140, https://openalex.org/W2075811312, https://openalex.org/W2168785906, https://openalex.org/W3080970792, https://openalex.org/W1997431917, https://openalex.org/W2154906308, https://openalex.org/W2141410747, https://openalex.org/W2525702246, https://openalex.org/W3002154790, https://openalex.org/W2428898098, https://openalex.org/W2089337258, https://openalex.org/W2148974089, https://openalex.org/W1904795858, https://openalex.org/W2079597727, https://openalex.org/W2161222316, https://openalex.org/W1977724195, https://openalex.org/W2037160755, https://openalex.org/W2035369297, https://openalex.org/W2046299975, https://openalex.org/W2026570544, https://openalex.org/W2050869737 |
| referenced_works_count | 31 |
| abstract_inverted_index.( | 13, 53, 129, 151, 171 |
| abstract_inverted_index.3 | 11 |
| abstract_inverted_index.7 | 52 |
| abstract_inverted_index.= | 132, 174 |
| abstract_inverted_index.a | 35, 123, 168 |
| abstract_inverted_index.p | 130, 152, 172 |
| abstract_inverted_index.), | 15 |
| abstract_inverted_index.). | 55 |
| abstract_inverted_index.In | 24 |
| abstract_inverted_index.as | 31, 48 |
| abstract_inverted_index.in | 6, 38, 57, 75, 115, 144, 164 |
| abstract_inverted_index.of | 3, 19, 67, 100, 112, 135, 161, 184, 199 |
| abstract_inverted_index.on | 69, 103 |
| abstract_inverted_index.to | 63, 95, 127, 149, 157, 213 |
| abstract_inverted_index.we | 61 |
| abstract_inverted_index.DNA | 9 |
| abstract_inverted_index.PCR | 91 |
| abstract_inverted_index.The | 89 |
| abstract_inverted_index.and | 43, 71, 80, 84, 106, 137, 186, 203 |
| abstract_inverted_index.are | 211 |
| abstract_inverted_index.can | 16, 33, 188 |
| abstract_inverted_index.its | 206 |
| abstract_inverted_index.our | 177 |
| abstract_inverted_index.the | 58, 97, 104, 140, 159, 181, 200 |
| abstract_inverted_index.was | 93, 122 |
| abstract_inverted_index.< | 154 |
| abstract_inverted_index.A375 | 116 |
| abstract_inverted_index.Beta | 12 |
| abstract_inverted_index.GAS7 | 54, 72, 107, 162, 201 |
| abstract_inverted_index.cell | 77, 117, 146 |
| abstract_inverted_index.gene | 114, 163 |
| abstract_inverted_index.line | 118, 147 |
| abstract_inverted_index.play | 34 |
| abstract_inverted_index.role | 37 |
| abstract_inverted_index.such | 30, 47 |
| abstract_inverted_index.that | 120, 180, 190 |
| abstract_inverted_index.this | 25 |
| abstract_inverted_index.were | 82 |
| abstract_inverted_index.aimed | 62 |
| abstract_inverted_index.cause | 17 |
| abstract_inverted_index.cells | 166 |
| abstract_inverted_index.gene, | 202 |
| abstract_inverted_index.genes | 4, 46, 73, 108 |
| abstract_inverted_index.line. | 78 |
| abstract_inverted_index.study | 60 |
| abstract_inverted_index.their | 191 |
| abstract_inverted_index.there | 121 |
| abstract_inverted_index.these | 40, 101 |
| abstract_inverted_index.tumor | 21 |
| abstract_inverted_index.using | 86 |
| abstract_inverted_index.value | 131, 153, 173 |
| abstract_inverted_index.0.05). | 155 |
| abstract_inverted_index.DNMT3B | 14, 70, 105, 113, 195 |
| abstract_inverted_index.arrest | 50 |
| abstract_inverted_index.caused | 194 |
| abstract_inverted_index.effect | 66, 99 |
| abstract_inverted_index.genes. | 23 |
| abstract_inverted_index.growth | 49 |
| abstract_inverted_index.miRNAs | 68 |
| abstract_inverted_index.showed | 119, 167, 179 |
| abstract_inverted_index.control | 128, 150 |
| abstract_inverted_index.enzymes | 42 |
| abstract_inverted_index.factors | 29 |
| abstract_inverted_index.predict | 64 |
| abstract_inverted_index.present | 59 |
| abstract_inverted_index.regard, | 26 |
| abstract_inverted_index.studies | 210 |
| abstract_inverted_index.various | 20, 27 |
| abstract_inverted_index.0.0015). | 133 |
| abstract_inverted_index.0.0323). | 175 |
| abstract_inverted_index.Aberrant | 1 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Analysis | 134 |
| abstract_inverted_index.Compared | 156 |
| abstract_inverted_index.Finally, | 176 |
| abstract_inverted_index.However, | 208 |
| abstract_inverted_index.aberrant | 192 |
| abstract_inverted_index.analysis | 111 |
| abstract_inverted_index.comment. | 215 |
| abstract_inverted_index.compared | 126, 148 |
| abstract_inverted_index.control, | 158 |
| abstract_inverted_index.critical | 36 |
| abstract_inverted_index.decrease | 170 |
| abstract_inverted_index.definite | 214 |
| abstract_inverted_index.findings | 178 |
| abstract_inverted_index.increase | 125 |
| abstract_inverted_index.involved | 5 |
| abstract_inverted_index.melanoma | 76, 145, 165 |
| abstract_inverted_index.possible | 197 |
| abstract_inverted_index.selected | 85 |
| abstract_inverted_index.specific | 51 |
| abstract_inverted_index.Real-time | 90 |
| abstract_inverted_index.decreased | 142, 182, 205 |
| abstract_inverted_index.including | 8 |
| abstract_inverted_index.indicated | 139 |
| abstract_inverted_index.microRNAs | 32 |
| abstract_inverted_index.molecular | 28 |
| abstract_inverted_index.molecules | 102 |
| abstract_inverted_index.necessary | 212 |
| abstract_inverted_index.performed | 94 |
| abstract_inverted_index.predicted | 83 |
| abstract_inverted_index.software. | 88 |
| abstract_inverted_index.technique | 92 |
| abstract_inverted_index.Expression | 110 |
| abstract_inverted_index.downstream | 45 |
| abstract_inverted_index.eventually | 44 |
| abstract_inverted_index.expression | 2, 74, 143, 160, 183, 193 |
| abstract_inverted_index.regulating | 39 |
| abstract_inverted_index.regulatory | 65, 98 |
| abstract_inverted_index.suppressor | 22 |
| abstract_inverted_index.ultimately | 204 |
| abstract_inverted_index.expression. | 109, 207 |
| abstract_inverted_index.hypothesize | 189 |
| abstract_inverted_index.investigate | 96 |
| abstract_inverted_index.methylation | 198 |
| abstract_inverted_index.significant | 124, 169 |
| abstract_inverted_index.Accordingly, | 56 |
| abstract_inverted_index.dysfunction, | 196 |
| abstract_inverted_index.methylation, | 7 |
| abstract_inverted_index.complementary | 209 |
| abstract_inverted_index.insignificant | 141 |
| abstract_inverted_index.bioinformatics | 87 |
| abstract_inverted_index.hsa-miR-29a-3p | 81, 138, 187 |
| abstract_inverted_index.hsa-miR-203a-3p | 79, 136, 185 |
| abstract_inverted_index.hypermethylation | 18 |
| abstract_inverted_index.methyltransferase | 10, 41 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5067871059, https://openalex.org/A5044315342 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I235686326 |
| citation_normalized_percentile.value | 0.55777231 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |