Predictive Value of Arterial Blood Lactic Acid Concentration on the Risk of in‐Hospital All‐Cause Death in Patients with Acute Heart Failure Article Swipe
Weiwei Hu
,
Lei Yuan
,
Xiaotong Wang
,
Baohe Zang
,
Yang Zhang
,
Xianliang Yan
,
Wenjing Zhao
,
Yali Chao
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/7644535
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1155/2022/7644535
The study aims to examine the predictive value of arterial blood lactic acid concentration for in‐hospital all‐cause mortality in the intensive care unit (ICU) for patients with acute heart failure (AHF). We retrospectively analyzed the clinical data of 7558 AHF patients in the Medical Information Mart for Intensive Care IV (MIMIC‐IV) database. The exposure variable of the present study was arterial blood lactic acid concentration and the outcome variable was in‐hospital all‐cause death. The patients were divided into those who survived ( n = 6792) and those who died ( n = 766). The multivariate logistic regression model, restricted cubic spline (RCS) plot, and subgroup analysis were used to evaluate the association between lactic acid and in‐hospital all‐cause mortality. In addition, receiver operating curve (ROC) analysis also was performed. Finally, we further explore the association between NT‐proBNP and lactic acid and in‐hospital all‐cause mortality. Compared with the lowest quartiles, the odds ratios with 95% confidence intervals for in‐hospital all‐cause mortality across the quartiles were 1.46 (1.07–2.00), 1.48 (1.09–2.00), and 2.36 (1.73–3.22) for lactic acid, and in‐hospital all‐cause mortality was gradually increased with lactic acid levels increasing ( P for trend <0.05). The RCS plot revealed a positive and linear connection between lactic acid and in‐hospital all‐cause mortality. A combination of lactic acid concentration and the Simplified Acute Physiology Score (SAPS) II may improve the predictive value of in‐hospital all‐cause mortality in patients with AHF (AUC = 0.696). Among subgroups, respiratory failure interacted with an association between lactic acid and in‐hospital all‐cause mortality ( P for interaction <0.05). The correlation heatmap revealed that NT‐proBNP was positively correlated with lactic acid ( r = 0.07) and positively correlated with in‐hospital all‐cause mortality ( r = 0.18). There was an inverse L‐shaped curve relationship between NT‐proBNP and in‐hospital all‐cause mortality, respectively. Mediation analysis suggested that a positive relationship between lactic acid and in‐hospital all‐cause death was mediated by NT‐proBNP. For AHF patients in the ICU, the arterial blood lactic acid concentration during hospitalization was a significant independent predictor of in‐hospital all‐cause mortality. The combination of lactic acid and SAPS II can improve the predictive value of the risk of in‐hospital all‐cause mortality in patients with AHF.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2022/7644535
- https://downloads.hindawi.com/journals/ijclp/2022/7644535.pdf
- OA Status
- gold
- Cited By
- 10
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309324512
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4309324512Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1155/2022/7644535Digital Object Identifier
- Title
-
Predictive Value of Arterial Blood Lactic Acid Concentration on the Risk of in‐Hospital All‐Cause Death in Patients with Acute Heart FailureWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-01-01Full publication date if available
- Authors
-
Weiwei Hu, Lei Yuan, Xiaotong Wang, Baohe Zang, Yang Zhang, Xianliang Yan, Wenjing Zhao, Yali ChaoList of authors in order
- Landing page
-
https://doi.org/10.1155/2022/7644535Publisher landing page
- PDF URL
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https://downloads.hindawi.com/journals/ijclp/2022/7644535.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://downloads.hindawi.com/journals/ijclp/2022/7644535.pdfDirect OA link when available
- Concepts
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Medicine, Quartile, Lactic acid, Odds ratio, Intensive care unit, Logistic regression, Internal medicine, Mortality rate, Receiver operating characteristic, Heart failure, Intensive care, Confidence interval, Intensive care medicine, Biology, Genetics, BacteriaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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