Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism Article Swipe
L. Reid
,
Bala Muthukrishnan
,
Dilip Patel
,
Jonathan R. Seckl
,
Fraser W. Gibb
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1210/jc.2018-02483
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1210/jc.2018-02483
Context Primary hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with increased risk of cardiovascular disease and mortality. Objective To identify risk factors for nephrolithiasis, osteoporosis, and mortality in PHPT. Design Retrospective cohort study. Setting University teaching hospital. Patients Presented with PHPT between 2006 and 2014 (n = 611). Main Outcome Measure Assessment of nephrolithiasis, osteoporosis, and mortality. Results Of patients with PHPT, 13.9% had nephrolithiasis. Most had previously documented stone disease, and only 4.7% of asymptomatic patients who were screened for renal stones had calculi identified, not very dissimilar to the rate in the non-PHPT population. Younger age (P < 0.001) and male sex (P = 0.003) were the only independent predictors of nephrolithiasis. Of patients with dual-energy X-ray absorptiometry data, 48.4% had osteoporosis (223/461). Older age (P < 0.001), lower body mass index (P = 0.002), and lower creatinine (P = 0.006) were independently associated with a diagnosis of osteoporosis. Higher PTH was independently associated with lower z score at the hip (P = 0.009); otherwise, calcium and PTH were not associated with lower z scores. Mortality in PHPT was associated with older age (P < 0.008), social deprivation (P = 0.028), and adjusted calcium (P = 0.009) but not independently with PTH at diagnosis. Conclusions Screening for nephrolithiasis has a low yield, particularly in lower risk patients. Osteoporosis is only minimally associated with biochemical indices of PHPT. Mortality is associated with higher calcium (and possibly vitamin D deficiency) but not PTH.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1210/jc.2018-02483
- https://academic.oup.com/jcem/article-pdf/104/9/3692/28969498/jc.2018-02483.pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2925000007Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/jc.2018-02483Digital Object Identifier
- Title
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Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary HyperparathyroidismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-03-27Full publication date if available
- Authors
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L. Reid, Bala Muthukrishnan, Dilip Patel, Jonathan R. Seckl, Fraser W. GibbList of authors in order
- Landing page
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https://doi.org/10.1210/jc.2018-02483Publisher landing page
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https://academic.oup.com/jcem/article-pdf/104/9/3692/28969498/jc.2018-02483.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/jcem/article-pdf/104/9/3692/28969498/jc.2018-02483.pdfDirect OA link when available
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Primary hyperparathyroidism, Medicine, Osteoporosis, Hyperparathyroidism, Internal medicine, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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43Total citation count in OpenAlex
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2025: 5, 2024: 3, 2023: 4, 2022: 11, 2021: 7Per-year citation counts (last 5 years)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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