Pregabalin poisoning: Evaluation of dose‐toxicity relationship Article Swipe
Saskia J. Rietjens
,
Maaike A. Sikma
,
Claudine C. Hunault
,
Dylan W. de Lange
,
Laura Hondebrink
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/bcp.15073
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/bcp.15073
Context Pregabalin poisoning is mostly benign, although coma and convulsions occasionally occur. Aim To determine the dose‐toxicity relationship of pregabalin. Methods Dose‐toxicity data of isolated pregabalin poisonings were collected from (1) a prospective study performed by the Dutch Poisons Information Centre (4 April 2014 to 4 October 2016) and from (2) case reports and case series reported in literature. Poisonings were graded using the Poisoning Severity Score (PSS) and the relationship between dose (mg kg −1 ) and PSS was evaluated. Results In our study (n = 21 patients), the most commonly observed symptoms were drowsiness (62%), confusion (29%) and apathy (24%). PSS was none in three (14%), minor in 15 (71%), and moderate in three patients (14%). Most case series also reported a PSS of none to minor in the majority of poisonings (69‐100%). For 34 individual patients (21 from our study and 13 from literature), detailed data on dose and clinical course were available to examine the dose‐toxicity relationship. The median dose was significantly lower in the PSS none‐minor group (“benign”) (8.6 mg kg −1 , interquartile range (IQ25‐75) 5.0‐17.6 mg kg −1 ) than in the PSS moderate‐severe group (“significant toxicity”) (46.7 mg kg −1 , IQ25‐75 21.3‐64.3 mg kg −1 ); estimate of the median difference = 27.3 mg kg −1 (95% confidence interval (CI): 10‐48.6). Conclusions In general, higher pregabalin doses result in more severe poisonings. Below 20 mg kg −1 the majority of patients (83%) only suffer from mild poisoning. However, large interindividual differences exist in pregabalin‐induced toxicity. Therefore, pre‐hospital triage should not only include pregabalin dose, but also underlying illnesses, co‐exposures and reported symptoms.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1111/bcp.15073
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.15073
- OA Status
- hybrid
- Cited By
- 15
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3197526146
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3197526146Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/bcp.15073Digital Object Identifier
- Title
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Pregabalin poisoning: Evaluation of dose‐toxicity relationshipWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-09-10Full publication date if available
- Authors
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Saskia J. Rietjens, Maaike A. Sikma, Claudine C. Hunault, Dylan W. de Lange, Laura HondebrinkList of authors in order
- Landing page
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https://doi.org/10.1111/bcp.15073Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.15073Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.15073Direct OA link when available
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Pregabalin, Medicine, Toxicity, Interquartile range, Coma (optics), Prospective cohort study, Anesthesia, Internal medicine, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
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15Total citation count in OpenAlex
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2025: 4, 2024: 2, 2023: 4, 2022: 4, 2021: 1Per-year citation counts (last 5 years)
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17Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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