Pregnancy exposure to synthetic phenols and placental DNA methylation — An epigenome-wide association study in male infants from the EDEN cohort Article Swipe
Paulina Jedynak
,
Jörg Tost
,
Antonia M. Calafat
,
Ekaterina Bourova-Flin
,
Florence Busato
,
Anne Forhan
,
Barbara Heude
,
Milan Jakobi
,
Sophie Rousseaux
,
Joel Schwartz
,
Rémy Slama
,
Daniel Vaiman
,
Claire Philippat
,
Johanna Lepeule
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.envpol.2021.118024
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1016/j.envpol.2021.118024
In utero exposure to environmental chemicals, such as synthetic phenols, may alter DNA methylation in different tissues, including placenta - a critical organ for fetal development. We studied associations between prenatal urinary biomarker concentrations of synthetic phenols and placental DNA methylation. Our study involved 202 mother-son pairs from the French EDEN cohort. Nine phenols were measured in spot urine samples collected between 22 and 29 gestational weeks. We performed DNA methylation analysis of the fetal side of placental tissues using the IlluminaHM450 BeadChips. We evaluated methylation changes of individual CpGs in an adjusted epigenome-wide association study (EWAS) and identified differentially methylated regions (DMRs). We performed mediation analysis to test whether placental tissue heterogeneity mediated the association between urinary phenol concentrations and DNA methylation. We identified 46 significant DMRs (≥5 CpGs) associated with triclosan (37 DMRs), 2,4-dichlorophenol (3), benzophenone-3 (3), methyl- (2) and propylparaben (1). All but 2 DMRs were positively associated with phenol concentrations. Out of the 46 identified DMRs, 7 (6 for triclosan) encompassed imprinted genes (APC, FOXG1, GNAS, GNASAS, MIR886, PEG10, SGCE), which represented a significant enrichment. Other identified DMRs encompassed genes encoding proteins responsible for cell signaling, transmembrane transport, cell adhesion, inflammatory, apoptotic and immunological response, genes encoding transcription factors, histones, tumor suppressors, genes involved in tumorigenesis and several cancer risk biomarkers. Mediation analysis suggested that placental cell heterogeneity may partly explain these associations. This is the first study describing the genome-wide modifications of placental DNA methylation associated with pregnancy exposure to synthetic phenols or their precursors. Our results suggest that cell heterogeneity might mediate the effects of triclosan exposure on placental DNA methylation. Additionally, the enrichment of imprinted genes within the DMRs suggests mechanisms by which certain exposures, mainly to triclosan, could affect fetal development.
Related Topics
Concepts
DNA methylation
Differentially methylated regions
Biology
Epigenome
Epigenetics
Methylation
Genetics
Gene
Gene expression
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.envpol.2021.118024
- OA Status
- hybrid
- Cited By
- 39
- References
- 130
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3193443227
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3193443227Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.envpol.2021.118024Digital Object Identifier
- Title
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Pregnancy exposure to synthetic phenols and placental DNA methylation — An epigenome-wide association study in male infants from the EDEN cohortWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-08-21Full publication date if available
- Authors
-
Paulina Jedynak, Jörg Tost, Antonia M. Calafat, Ekaterina Bourova-Flin, Florence Busato, Anne Forhan, Barbara Heude, Milan Jakobi, Sophie Rousseaux, Joel Schwartz, Rémy Slama, Daniel Vaiman, Claire Philippat, Johanna LepeuleList of authors in order
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https://doi.org/10.1016/j.envpol.2021.118024Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.envpol.2021.118024Direct OA link when available
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DNA methylation, Differentially methylated regions, Biology, Epigenome, Epigenetics, Methylation, Genetics, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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39Total citation count in OpenAlex
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2024: 13, 2023: 12, 2022: 14Per-year citation counts (last 5 years)
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130Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.triclosan, | 284 |
| abstract_inverted_index.association | 94, 115 |
| abstract_inverted_index.biomarkers. | 214 |
| abstract_inverted_index.encompassed | 164, 182 |
| abstract_inverted_index.enrichment. | 178 |
| abstract_inverted_index.genome-wide | 234 |
| abstract_inverted_index.gestational | 65 |
| abstract_inverted_index.methylation | 13, 70, 85, 239 |
| abstract_inverted_index.precursors. | 249 |
| abstract_inverted_index.represented | 175 |
| abstract_inverted_index.responsible | 186 |
| abstract_inverted_index.significant | 126, 177 |
| abstract_inverted_index.associations | 28 |
| abstract_inverted_index.development. | 25, 288 |
| abstract_inverted_index.methylation. | 40, 122, 266 |
| abstract_inverted_index.suppressors, | 205 |
| abstract_inverted_index.Additionally, | 267 |
| abstract_inverted_index.IlluminaHM450 | 81 |
| abstract_inverted_index.associations. | 226 |
| abstract_inverted_index.environmental | 4 |
| abstract_inverted_index.heterogeneity | 112, 221, 255 |
| abstract_inverted_index.immunological | 197 |
| abstract_inverted_index.inflammatory, | 194 |
| abstract_inverted_index.modifications | 235 |
| abstract_inverted_index.propylparaben | 142 |
| abstract_inverted_index.transcription | 201 |
| abstract_inverted_index.transmembrane | 190 |
| abstract_inverted_index.tumorigenesis | 209 |
| abstract_inverted_index.benzophenone-3 | 137 |
| abstract_inverted_index.concentrations | 33, 119 |
| abstract_inverted_index.differentially | 99 |
| abstract_inverted_index.epigenome-wide | 93 |
| abstract_inverted_index.concentrations. | 153 |
| abstract_inverted_index.2,4-dichlorophenol | 135 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5011439580 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I899635006 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6600000262260437 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.93966575 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |