Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBC Article Swipe
Ashish Singh
,
Josh Thomas Georgy
,
Divya Bala Thumaty
,
Ajoy Oommen John
,
Nithya Ramnath
,
Anjana Joel
,
Tarun K George
,
Parth Sharma
,
Shalom Patole
,
Grace Rebekah
,
Elanthenral Sigamani
,
Marie Therese Manipadam
,
Anish Jacob Cherian
,
Deepak Thomas Abraham
,
Mazhuvanchary Jacob Paul
,
Rajesh Balakrishnan
,
Patricia Sebastian
,
Selvamani Backianathan
,
Raju Titus Chacko
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1519744/v2
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1519744/v2
Purpose The addition of carboplatin has improved pathological complete response (PCR) and event-free survival (EFS) and is becoming a new standard of care for early triple-negative breast cancer (TNBC). However, this comes at the expense of increased toxicity. Here, we aimed to evaluate a novel cisplatin-based chemotherapy regimen for early TNBC. Methods Women with early TNBC who were administered neoadjuvant chemotherapy consisting of four cycles of docetaxel and cyclophosphamide alternated with cisplatin and epirubicin (ddDCEP) given every two weeks over a 16-week period were analyzed in this retrospective real-world study, driven by physician preference. The major outcomes assessed were PCR and EFS. Other outcomes included overall survival, treatment delivery, and adverse events. Results From January 2017 to January 2020, 116 women with stage I-III TNBC received neoadjuvant ddDCEP. PCR (ypT0/TisN0) was observed in 55.2% of evaluable patients. The PCR in stage I/II disease was 62.2%, and stage III was 49.5%. 37.9% of patients developed grade 3 anemia during treatment. Incidence of grade 3/4 neutropenia was 16.3%, and febrile neutropenia was 4.3%. 86% of patients completed all 8 cycles of planned chemotherapy, and 98% at least 6 out of 8 cycles. 12% patients required dose reduction of taxane and 19% for cisplatin. At 30 months of median follow-up, the EFS was 91.2%, and overall survival was 97%. Cost analysis showed this regimen was more cost-effective than carboplatin-based regimens. Conclusion Treatment with ddDCEP led to pCR in a significant proportion of patients, with high completion rates and lower toxicity, particularly neutropenia. These findings suggest that ddDCEP may be a promising, cost-effective treatment option for early TNBC.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1519744/v2
- OA Status
- gold
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313855368
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4313855368Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-1519744/v2Digital Object Identifier
- Title
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Preoperative dose-dense docetaxel and cyclophosphamide alternating with epirubicin and cisplatin(ddDCEP): an effective, novel way of incorporating platinum in the treatment of early TNBCWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-09Full publication date if available
- Authors
-
Ashish Singh, Josh Thomas Georgy, Divya Bala Thumaty, Ajoy Oommen John, Nithya Ramnath, Anjana Joel, Tarun K George, Parth Sharma, Shalom Patole, Grace Rebekah, Elanthenral Sigamani, Marie Therese Manipadam, Anish Jacob Cherian, Deepak Thomas Abraham, Mazhuvanchary Jacob Paul, Rajesh Balakrishnan, Patricia Sebastian, Selvamani Backianathan, Raju Titus ChackoList of authors in order
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https://doi.org/10.21203/rs.3.rs-1519744/v2Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.21203/rs.3.rs-1519744/v2Direct OA link when available
- Concepts
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Epirubicin, Docetaxel, Cisplatin, Cyclophosphamide, Medicine, Oncology, Pharmacology, Chemotherapy, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.real-world | 89 |
| abstract_inverted_index.treatment. | 159 |
| abstract_inverted_index.carboplatin | 5 |
| abstract_inverted_index.neoadjuvant | 60, 127 |
| abstract_inverted_index.neutropenia | 164, 169 |
| abstract_inverted_index.preference. | 94 |
| abstract_inverted_index.significant | 237 |
| abstract_inverted_index.(ypT0/TisN0) | 130 |
| abstract_inverted_index.administered | 59 |
| abstract_inverted_index.chemotherapy | 47, 61 |
| abstract_inverted_index.neutropenia. | 249 |
| abstract_inverted_index.particularly | 248 |
| abstract_inverted_index.pathological | 8 |
| abstract_inverted_index.chemotherapy, | 181 |
| abstract_inverted_index.retrospective | 88 |
| abstract_inverted_index.cost-effective | 224, 259 |
| abstract_inverted_index.cisplatin-based | 46 |
| abstract_inverted_index.triple-negative | 26 |
| abstract_inverted_index.cyclophosphamide | 69 |
| abstract_inverted_index.carboplatin-based | 226 |
| abstract_inverted_index.<bold>Methods</bold> | 52 |
| abstract_inverted_index.<bold>Purpose</bold> | 1 |
| abstract_inverted_index.<bold>Results</bold> | 113 |
| abstract_inverted_index.<bold>Conclusion</bold> | 228 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5042972991 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 19 |
| corresponding_institution_ids | https://openalex.org/I172917736 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.00200154 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |