Preparation and Bioavailability Analysis of Ferrous Bis Alanine Chelate as a New Micronutrient for Treatment of Iron Deficiency Anemia Article Swipe
Marzieh Zargaran
,
Ebrahim Saadat
,
Rassoul Dinarvand
,
Mohammad Sharifzadeh
,
Farid Abedin Dorkoosh
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.15171/apb.2016.053
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.15171/apb.2016.053
Purpose: One of the most nutritional disorders around the world is iron deficiency. A novel iron compound was synthesized by chelating ferrous ions with alanine for prevention and treatment of iron deficiency anemia. Methods: The newly synthesized compound was characterized both qualitatively and quantitatively by Fourier Transform Infrared (FT-IR) spectroscopy. The bioavailability of newly synthesized iron micronutrient was evaluated in four groups of Wistar rats. The group I was a negative control group and the other three groups received three different iron formulations. After 14 days, the blood samples were taken and analyzed accordingly. Results: Calculations showed that more than 91.8% of iron was incorporated in the chelate formulation. In vivo studies showed that serum iron, total iron binding capacity and hemoglobin concentrations were significantly increased in group IV, which received ferrous bis alanine chelate compared with the negative control group (p<0.05) and also group II, which received ferrous sulfate.7H2O (p<0.05). It indicates that the new formulation considerably improves the blood iron status compared with the conventional iron compounds. There were no significant differences (p<0.05) in the serum iron between group IV and group III, which received ferrous bis glycine. Conclusion: The results showed better bioavailability of ferrous bis alanine as a new micronutrient for treatment of iron deficiency anemia in comparison with ferrous sulfate. Ferrous bis alanine could be considered as a suitable supplement for prevention and treatment of iron deficiency anemia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.15171/apb.2016.053
- https://apb.tbzmed.ac.ir/PDF/APB_4066_20160314151653
- OA Status
- diamond
- Cited By
- 3
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2531049540
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2531049540Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.15171/apb.2016.053Digital Object Identifier
- Title
-
Preparation and Bioavailability Analysis of Ferrous Bis Alanine Chelate as a New Micronutrient for Treatment of Iron Deficiency AnemiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-09-25Full publication date if available
- Authors
-
Marzieh Zargaran, Ebrahim Saadat, Rassoul Dinarvand, Mohammad Sharifzadeh, Farid Abedin DorkooshList of authors in order
- Landing page
-
https://doi.org/10.15171/apb.2016.053Publisher landing page
- PDF URL
-
https://apb.tbzmed.ac.ir/PDF/APB_4066_20160314151653Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://apb.tbzmed.ac.ir/PDF/APB_4066_20160314151653Direct OA link when available
- Concepts
-
Ferrous, Micronutrient, Chemistry, Iron-deficiency anemia, Bioavailability, Hemoglobin, Anemia, Deferiprone, Chelation, Alanine, Nuclear chemistry, Ferrous sulphate, Sulfate, Iron deficiency, Internal medicine, Biochemistry, Inorganic chemistry, Medicine, Pharmacology, Amino acid, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2021: 1, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
23Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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