Preparation and characterization of sorafenib-loading microcapsules by complex coacervation of gum Arabic with chitosan or modified chitosan Article Swipe
Chi Uyen Phan
,
Thi Trung Chinh Nguyen
,
Thi Van Thanh
,
Guping Tang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1590/1517-7076-rmat-2023-0015
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1590/1517-7076-rmat-2023-0015
Sorafenib is an oral multi-target kinase inhibitor that has been used to treat unresectable hepatocellular carcinoma and advanced renal cell carcinoma. The aim of the study was to prepare gum Arabic-chitosan (GA-CS) and gum Arabic-modified chitosan (GA-MCS) microcapsules containing sorafenib as the core phase by complex coacervation. The fluorescence microscopy, dynamic light scattering (DLS), drug loading, and encapsulation efficiency of the microcapsules were clarified. The GA-MCS microcapsule was successfully performed at approximate pH of 4 with a 1% modified chitosan -to- 5% gum Arabic ratio of 5:1 (v/v), while the GA-CS microcapsule was successfully prepared at pH 3.5 with a volume ratio of 1% chitosan -to- 5% gum Arabic 1:1 (v/v). Sorafenib was encapsulated in the microcapsules as shown through the fluorescence microscopy images. The formation of GA-CS and GA-MCS microcapsules with hydrodynamic sizes of 6.31 μm and 6.56 μm, respectively, was successfully achieved. The drug loading and encapsulation efficiency of the GA-MCS microcapsule was greater than that of the GA-CS microcapsule. The findings indicated that the GA-MCS microcapsule could be an appropriate formation to load sorafenib with a high encapsulation yield.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1590/1517-7076-rmat-2023-0015
- https://www.scielo.br/j/rmat/a/yKzxvKHTJ4XWV8b6fNwbXDQ/?lang=en&format=pdf
- OA Status
- diamond
- Cited By
- 2
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4365804143
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4365804143Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1590/1517-7076-rmat-2023-0015Digital Object Identifier
- Title
-
Preparation and characterization of sorafenib-loading microcapsules by complex coacervation of gum Arabic with chitosan or modified chitosanWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-01Full publication date if available
- Authors
-
Chi Uyen Phan, Thi Trung Chinh Nguyen, Thi Van Thanh, Guping TangList of authors in order
- Landing page
-
https://doi.org/10.1590/1517-7076-rmat-2023-0015Publisher landing page
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https://www.scielo.br/j/rmat/a/yKzxvKHTJ4XWV8b6fNwbXDQ/?lang=en&format=pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
diamondOpen access status per OpenAlex
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https://www.scielo.br/j/rmat/a/yKzxvKHTJ4XWV8b6fNwbXDQ/?lang=en&format=pdfDirect OA link when available
- Concepts
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Coacervate, Chitosan, Gum arabic, Sorafenib, Arabic, Dynamic light scattering, Materials science, Chemistry, Chemical engineering, Nuclear chemistry, Chromatography, Nanotechnology, Hepatocellular carcinoma, Nanoparticle, Organic chemistry, Medicine, Engineering, Cancer research, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2023-01-01 |
| publication_year | 2023 |
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