Preparation and Evaluation of Pioglitazone Tablet by Solid Dispersion Technique Article Swipe
Parag Sharma
,
Vijay K. Sharma
,
Nuggehalli M. Ravindra
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.32553/jddt.v11i3.468
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.32553/jddt.v11i3.468
Pioglitazone is an oral hypoglycemic drug, used for the treatment of type 2 diabetes. The main objectives of this study were to improve aqueous solubility of Pioglitazone by preparing its solid dispersion by fusion method using various carriers that will improve its absorption and subsequent bioavailability. The prepared tablets (TF1-TF5) were evaluated for various parameters i.e.shape and size, weight variation, hardness, friability, disintegration time, drug content etc. The prepared tablet passed all the tests.Finally, it can be concluded that solid dispersion of Pioglitazone may be prepared to improve its solubility and dissolution. This will lead to better absorption and hence improved bioavailability of the drug (Pioglitazone).
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.32553/jddt.v11i3.468
- https://www.jddt.in/index.php/jddt/article/download/468/410
- OA Status
- diamond
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4376507686
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4376507686Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.32553/jddt.v11i3.468Digital Object Identifier
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Preparation and Evaluation of Pioglitazone Tablet by Solid Dispersion TechniqueWork title
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articleOpenAlex work type
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enPrimary language
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2023Year of publication
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2023-05-14Full publication date if available
- Authors
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Parag Sharma, Vijay K. Sharma, Nuggehalli M. RavindraList of authors in order
- Landing page
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https://doi.org/10.32553/jddt.v11i3.468Publisher landing page
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https://www.jddt.in/index.php/jddt/article/download/468/410Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://www.jddt.in/index.php/jddt/article/download/468/410Direct OA link when available
- Concepts
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Pioglitazone, Bioavailability, Dissolution, Friability, Solubility, Dispersion (optics), Absorption (acoustics), Chemistry, Chromatography, Materials science, Pharmacology, Type 2 diabetes, Medicine, Diabetes mellitus, Organic chemistry, First pass effect, Endocrinology, Composite material, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.objectives | 16 |
| abstract_inverted_index.parameters | 54 |
| abstract_inverted_index.solubility | 24, 89 |
| abstract_inverted_index.subsequent | 44 |
| abstract_inverted_index.variation, | 59 |
| abstract_inverted_index.friability, | 61 |
| abstract_inverted_index.Pioglitazone | 0, 26, 82 |
| abstract_inverted_index.dissolution. | 91 |
| abstract_inverted_index.hypoglycemic | 4 |
| abstract_inverted_index.disintegration | 62 |
| abstract_inverted_index.tests.Finally, | 73 |
| abstract_inverted_index.(Pioglitazone). | 105 |
| abstract_inverted_index.bioavailability | 101 |
| abstract_inverted_index.bioavailability. | 45 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 3 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.5799999833106995 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.07397663 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |