Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacin Article Swipe
Ali Rassouli
,
Sakineh Khanamani Falahatipour
,
Yalda H. Ardakani
,
Hamid Akbari Javar
,
Katayoun Kiani
,
Taghi Zahraee Salehi
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22067/veterinary.v10i1.70288
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.22067/veterinary.v10i1.70288
The implantable drug products are developed mainly to sustain the drug release. This study was conducted to formulate and evaluate cross-linked films of chitosan/β-glycerophosphate (β-GP) for the sustained delivery of enrofloxacin (ENR). Two types of formulations, single-layer (F1 and F2) and triple-layer (F3 and F4) films, were prepared. In vitro drug release, kinetic modelling, Fourier transform infrared spectroscopy (FTIR) spectra, morphological and microbiological studies were performed. Drug release from F1 and F2 continued up to 5 hours but from F3 and F4, it was extended over 96 and 168 hours, respectively. The cumulative drug release for F1, F2, F3 and F4 were 72.6, 70.1, 90.5 and 82.4%, respectively. The inhibition zones of bacterial growth by using positive controls and single layer films were significantly greater than those of triple-layer films (p < 0.05), indicating sustained drug release pattern of the multi-layer films. These findings suggest that the triple-layer chitosan/β-GP films could be effective to deliver ENR for a long period.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doaj.org/article/ac0ae1ed86ce41bfbbaffbc41a168913
- OA Status
- green
- Cited By
- 2
- Related Works
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All OpenAlex metadata
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https://openalex.org/W2888420077Canonical identifier for this work in OpenAlex
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https://doi.org/10.22067/veterinary.v10i1.70288Digital Object Identifier
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Preparation and in vitro evaluation of chitosan-based films for the sustained delivery of enrofloxacinWork title
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articleOpenAlex work type
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enPrimary language
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2018Year of publication
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2018-10-01Full publication date if available
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Ali Rassouli, Sakineh Khanamani Falahatipour, Yalda H. Ardakani, Hamid Akbari Javar, Katayoun Kiani, Taghi Zahraee SalehiList of authors in order
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https://doaj.org/article/ac0ae1ed86ce41bfbbaffbc41a168913Publisher landing page
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greenOpen access status per OpenAlex
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https://doaj.org/article/ac0ae1ed86ce41bfbbaffbc41a168913Direct OA link when available
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Enrofloxacin, Chitosan, In vitro, Drug delivery, Pharmacology, Chemistry, Materials science, Medicine, Nanotechnology, Organic chemistry, Biochemistry, Antibiotics, CiprofloxacinTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.F2) | 39 |
| abstract_inverted_index.F2, | 97 |
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| abstract_inverted_index.(FTIR) | 58 |
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| abstract_inverted_index.82.4%, | 106 |
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| abstract_inverted_index.mainly | 6 |
| abstract_inverted_index.single | 119 |
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| institutions_distinct_count | 6 |
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| citation_normalized_percentile.is_in_top_10_percent | False |