Preparation and Optimization of O/W Emulsions Stabilized by Triglycerol Monolaurate for Curcumin Encapsulation Article Swipe
Guiqiong Zhang
,
Qiang Zhang
,
Lan Wang
,
Lei Ji
,
Pengbing Han
,
Fengju Zhao
,
Qun Su
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27248861
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/molecules27248861
Curcumin is one of the most studied chemo-preventive agents, which may cause suppression, retardation, or inversion of carcinogenesis. But its application is currently limited because of its poor water-solubility and bioaccessibility. A curcumin O/W emulsion was prepared by high-pressure homogenization, using triglyceride monolaurate as an emulsifier and medium chain triglycerides (MCT) as the oil phase. The effects of emulsifiers, emulsifier concentration, oil type, oil-to-water ratio, and homogenization pressure and processing cycles on the physical stability and droplet size distribution of curcumin-encapsulated O/W emulsions were evaluated in this study. The results showed that the mean droplet size of the O/W emulsions remained remarkably stable during 60 days of storage under both light and dark conditions. Curcumin retentions in O/W emulsions after 60 days of storage under light and dark conditions were 97.9% and 81.6%, respectively. In addition, during the simulated gastrointestinal digestion process, the mean droplet size of the O/W emulsions increased from 260 nm to 2743 nm after incubation with simulated gastric fluid (SGF) for 24 h, while the mean droplet size remained unchanged after incubation with simulated intestinal fluid (SIF). The results displayed negligible changes in curcumin content during incubation with simulated gastrointestinal fluids, indicating that effective protection of curcumin was achieved by encapsulation in the O/W emulsion. It is expected that curcumin will acquire high bioaccessibility and bioavailability when the O/W emulsion is to be used in clinical applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules27248861
- https://www.mdpi.com/1420-3049/27/24/8861/pdf?version=1671515086
- OA Status
- gold
- Cited By
- 3
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311364001
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4311364001Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules27248861Digital Object Identifier
- Title
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Preparation and Optimization of O/W Emulsions Stabilized by Triglycerol Monolaurate for Curcumin EncapsulationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-13Full publication date if available
- Authors
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Guiqiong Zhang, Qiang Zhang, Lan Wang, Lei Ji, Pengbing Han, Fengju Zhao, Qun SuList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules27248861Publisher landing page
- PDF URL
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https://www.mdpi.com/1420-3049/27/24/8861/pdf?version=1671515086Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/27/24/8861/pdf?version=1671515086Direct OA link when available
- Concepts
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Curcumin, Emulsion, Bioavailability, Chemistry, Solubility, Chromatography, Homogenization (climate), Particle size, Gastric fluid, Biochemistry, Organic chemistry, Pharmacology, Biology, Ecology, Physical chemistry, Medicine, BiodiversityTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 2, 2023: 1Per-year citation counts (last 5 years)
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33Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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