Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizer Article Swipe
Houra Nekounam
,
Rassoul Dinarvand
,
Rahele Khademi
,
Roya Karimi
,
Hossein Arzani
,
Narges Mahmoodi
,
Elham Hasanzadeh
,
Morteza Kamali
,
Masood Khosravani
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.05.15.444280
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.05.15.444280
Indirubin can be applied as an anti-cancer drug for inhibition of brain tumors. However, its performance is reduced due to hydrophobicity. In this study, we synthesized cationic human serum albumin (CHSA) nanoparticle by a new hybrid approach for improvement the surface chemistry of albumin and investigate the amount of indirubin loaded CHSA nanoparticle. In this study, the generated mechanical force from a high-pressure homogenizer (HPH) was used to make nanoparticles with a certain size with narrow polydispersity. The results indicated that the size of indirubin loaded CHSA nanoparticles were 130 nm and their zeta potential were +9. Besides, the encapsulation efficiency and drug loading capacity were found to be 85% and 5.8 %, respectively. To the best to our knowledge, this is the first time that indirubin has been used in albumin nanoparticles. In this study, indirubin loaded CHSA nanoparticles was shown can be a potential candidate for drug delivery in the treatment of glioblastoma. Moreover, the cationized form allows the chemical agent to be transmitted to the brain.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.05.15.444280
- https://www.biorxiv.org/content/biorxiv/early/2021/08/18/2021.05.15.444280.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3160591964
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3160591964Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.05.15.444280Digital Object Identifier
- Title
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Preparation of cationized albumin nanoparticles loaded indirubin by high pressure hemogenizerWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-05-17Full publication date if available
- Authors
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Houra Nekounam, Rassoul Dinarvand, Rahele Khademi, Roya Karimi, Hossein Arzani, Narges Mahmoodi, Elham Hasanzadeh, Morteza Kamali, Masood KhosravaniList of authors in order
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https://doi.org/10.1101/2021.05.15.444280Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/08/18/2021.05.15.444280.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/08/18/2021.05.15.444280.full.pdfDirect OA link when available
- Concepts
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Indirubin, Zeta potential, Dispersity, Nanoparticle, Chemistry, Homogenizer, Albumin, Drug delivery, Human serum albumin, Nuclear chemistry, Chemical engineering, Nanotechnology, Materials science, Chromatography, Polymer chemistry, Organic chemistry, Biochemistry, Visual arts, Art, Engineering, IndigoTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2023: 2Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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