Presence of nicotinic acetylcholine receptors in cat carotid body afferent system Article Swipe

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Machiko Shirahata , Yumiko Ishizawa , Maria Rudisill , Brian Schofield , Robert S. Fitzgerald ·

YOU? · · 1998 · Open Access · · DOI: https://doi.org/10.1016/s0006-8993(98)01015-4 · OA: W2103469008

With immunocytochemical techniques using a monoclonal antibody for alpha7 subunits of neuronal nicotinic acetylcholine receptors, we have found these subunits to be exclusively expressed in nerve fibers in the carotid body. Double-immunostaining showed that alpha7 subunit-positive nerve endings enveloped tyrosine hydroxylase-positive glomus cells. Some carotid sinus nerve fibers and tyrosine hydroxylase-positive petrosal ganglion neurons also expressed alpha7 subunits. These data support a role for acetylcholine in carotid body neurotransmission.