Preservation of the Innate Immune Response toClostridioides difficileInfection in Hospitalized Immunocompromised Patients Article Swipe
Marcela Banegas
,
Javier Villafuerte-Gálvez
,
Rodrigo Paredes
,
Rebecca Sprague
,
Caitlin Barrett
,
Anne J Gonzales-Luna
,
Kaitlyn Daugherty
,
Kevin W. Garey
,
Hua Xu
,
Qianyun Lin
,
Lamei Wang
,
Xinhua Chen
,
Nira R. Pollock
,
Ciarán P. Kelly
,
Carolyn D. Alonso
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad090
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/ofid/ofad090
Background Clostridioides difficile infection (CDI) immune response is influenced by the innate and adaptive (humoral) immune systems. Our prior research found attenuated humoral responses to C difficile in immunocompromised hosts (ICHs) with CDI. We sought to evaluate whether the innate immune response to CDI was influenced by ICH status. Methods We conducted a prospective study of hospitalized adults with CDI (acute diarrhea, positive C difficile stool nucleic acid amplification testing [NAAT], and decision to treat), with and without immunosuppression and measured a panel of cytokines (granulocyte colony-stimulating factor [G-CSF], interleukin [IL]–10, IL-15, IL-1β, IL-4, IL-6, IL-8, and tumor necrosis factor–α) in blood and stool at CDI diagnosis. Results were compared with measurements from a cohort of asymptomatic carrier patients (ASCs) (NAAT positive, without diarrhea) with and without immunocompromise. Results One hundred twenty-three subjects (42 ICHs, 50 non-ICHs, 31 ASCs) were included. Median values for blood and stool cytokines were similar in ICH versus non-ICH CDI subjects. In blood, G-CSF, IL-10, IL-15, IL-6, and IL-8 were higher in both groups of CDI subjects versus the ASC cohort (P < .05). In stool, IL-1β and IL-8 were higher in both groups of CDI subjects versus the ASC cohort (P < .05). Median stool concentrations of IL-1β demonstrated significant differences between the groups (ICHs, 10.97 pg/mL; non-ICHs, 9.71 pg/mL; and ASCs, 0.56 pg/mL) (P < .0001). Conclusions In this small exploratory analysis, ICH status did not significantly impact blood and fecal patterns of cytokines in humans at the diagnosis of CDI, suggesting that the innate immune response to C difficile may be conserved in immunocompromised patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ofid/ofad090
- OA Status
- gold
- Cited By
- 2
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4321327223
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4321327223Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ofid/ofad090Digital Object Identifier
- Title
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Preservation of the Innate Immune Response toClostridioides difficileInfection in Hospitalized Immunocompromised PatientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-18Full publication date if available
- Authors
-
Marcela Banegas, Javier Villafuerte-Gálvez, Rodrigo Paredes, Rebecca Sprague, Caitlin Barrett, Anne J Gonzales-Luna, Kaitlyn Daugherty, Kevin W. Garey, Hua Xu, Qianyun Lin, Lamei Wang, Xinhua Chen, Nira R. Pollock, Ciarán P. Kelly, Carolyn D. AlonsoList of authors in order
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https://doi.org/10.1093/ofid/ofad090Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1093/ofid/ofad090Direct OA link when available
- Concepts
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Clostridioides, Medicine, Innate immune system, Immunology, Clostridium difficile, Immune system, Intensive care medicine, Internal medicine, Antibiotics, Microbiology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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22Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5010071991 |
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| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I1316535847, https://openalex.org/I136199984 |
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