Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccine Article Swipe
Sarah Conway
,
Shrishti Saxena
,
Clare Baecher‐Allan
,
Rajesh Krishnan
,
Maria K. Houtchens
,
Bonnie I. Glanz
,
Taylor J. Saraceno
,
Mariann Polgar‐Turcsanyi
,
Gauruv Bose
,
Rohit Bakshi
,
Shamik Bhattacharyya
,
Kristin Galetta
,
Tamara Kaplan
,
Christopher Severson
,
Tarun Singhal
,
Lynn Stazzone
,
Jonathan Zurawski
,
Anu Paul
,
Howard L. Weiner
,
Brian C. Healy
,
Tanuja Chitnis
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/20552173231165196
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1177/20552173231165196
Background There is limited knowledge about T cell responses in patients with multiple sclerosis (MS) after 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. Objectives Assess the SARS-CoV-2 spike antibody and T cell responses in MS patients and healthy controls (HCs) after 2 doses (2-vax) and 3 doses (3-vax) of SARS-CoV-2 mRNA vaccination. Methods We studied seroconversion rates and T cell responses by flow cytometry in HC and MS patients on fingolimod or ocrelizumab. Results After 2-vax, 8/33 (24.2%) patients in ocrelizumab group, 5/7 (71.4%) in fingolimod group, and 29/29 (100%) in HC group ( P = 5.7 × 10 −11 ) seroconverted. After 3-vax, 9/22 (40.9%) patients in ocrelizumab group, 19/21 (90.5%) in fingolimod group, and 7/7 (100%) in HC group seroconverted ( P = 0.0003). The percentage of SARS-CoV-2 peptide reactive total CD4+ T cells increased in HC and ocrelizumab group but not in fingolimod group after 2-vax and 3-vax ( P < 0.0001). The percentage of IFNγ and TNFα producing total CD4+ and CD8+ T cells increased in fingolimod group as compared to HC and ocrelizumab group after 2-vax and 3-vax ( P < 0.0001). Conclusions MS patients on ocrelizumab and fingolimod had attenuated humoral responses, but preserved cytokine producing T cell responses compared to HCs after SARS-CoV-2 mRNA vaccination. Clinical Trials Registration NCT05060354.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/20552173231165196
- OA Status
- gold
- Cited By
- 6
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362613310
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362613310Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/20552173231165196Digital Object Identifier
- Title
-
Preserved T cell but attenuated antibody response in MS patients on fingolimod and ocrelizumab following 2nd and 3rd SARS-CoV-2 mRNA vaccineWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-04-01Full publication date if available
- Authors
-
Sarah Conway, Shrishti Saxena, Clare Baecher‐Allan, Rajesh Krishnan, Maria K. Houtchens, Bonnie I. Glanz, Taylor J. Saraceno, Mariann Polgar‐Turcsanyi, Gauruv Bose, Rohit Bakshi, Shamik Bhattacharyya, Kristin Galetta, Tamara Kaplan, Christopher Severson, Tarun Singhal, Lynn Stazzone, Jonathan Zurawski, Anu Paul, Howard L. Weiner, Brian C. Healy, Tanuja ChitnisList of authors in order
- Landing page
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https://doi.org/10.1177/20552173231165196Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1177/20552173231165196Direct OA link when available
- Concepts
-
Ocrelizumab, Medicine, Fingolimod, Immunology, Internal medicine, Multiple sclerosis, T cell, Antibody, Immune system, RituximabTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 4Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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