Prevalence and characterization of piperaquine, mefloquine and artemisinin derivatives triple-resistant Plasmodium falciparum in Cambodia Article Swipe
Mélissa Mairet-Khedim
,
Camille Roesch
,
Nimol Khim
,
Sreynet Srun
,
Anthony Bouillon
,
Saorin Kim
,
Sopheakvatey Ke
,
Chhayleang Kauy
,
Nimol Kloeung
,
Rotha Eam
,
Chanra Khean
,
Chanvong Kul
,
Sophy Chy
,
Rithea Leang
,
Pascal Ringwald
,
Jean-Christophe Barale
,
Benoît Witkowski
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/jac/dkac403
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1093/jac/dkac403
Background In early 2016, in Preah Vihear, Northern Cambodia, artesunate/mefloquine was used to cope with dihydroartemisinin/piperaquine-resistant Plasmodium falciparum parasites. Following this policy, P. falciparum strains harbouring molecular markers associated with artemisinin, piperaquine and mefloquine resistance have emerged. However, the lack of a viable alternative led Cambodia to adopt artesunate/mefloquine countrywide, raising concerns about a surge of triple-resistant P. falciparum strains. Objectives To assess the prevalence of triple-resistant parasites after artesunate/mefloquine implementation countrywide in Cambodia and to characterize their phenotype. Methods For this multicentric study, 846 samples were collected from 2016 to 2019. Genotyping of molecular markers associated with artemisinin, piperaquine and mefloquine resistance was coupled with phenotypic analyses. Results Only four triple-resistant P. falciparum isolates (0.47%) were identified during the study period. These parasites combined the pfk13 polymorphism with pfmdr1 amplification, pfpm2 amplification and/or pfcrt mutations. They showed significantly higher tolerance to artemisinin, piperaquine and mefloquine and also to the mefloquine and piperaquine combination. Conclusions The use of artesunate/mefloquine countrywide in Cambodia has not led to a massive increase of triple-resistant P. falciparum parasites. However, these parasites circulate in the population, and exhibit clear resistance to piperaquine, mefloquine and their combination in vitro. This study demonstrates that P. falciparum can adapt to more complex drug associations, which should be considered in future therapeutic designs.
Related Topics
Concepts
Mefloquine
Piperaquine
Artesunate
Artemisinin
Plasmodium falciparum
Virology
Biology
Malaria
Immunology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jac/dkac403
- https://academic.oup.com/jac/article-pdf/78/2/411/48957810/dkac403.pdf
- OA Status
- hybrid
- Cited By
- 3
- References
- 15
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4311203316
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4311203316Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/jac/dkac403Digital Object Identifier
- Title
-
Prevalence and characterization of piperaquine, mefloquine and artemisinin derivatives triple-resistant Plasmodium falciparum in CambodiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-12-12Full publication date if available
- Authors
-
Mélissa Mairet-Khedim, Camille Roesch, Nimol Khim, Sreynet Srun, Anthony Bouillon, Saorin Kim, Sopheakvatey Ke, Chhayleang Kauy, Nimol Kloeung, Rotha Eam, Chanra Khean, Chanvong Kul, Sophy Chy, Rithea Leang, Pascal Ringwald, Jean-Christophe Barale, Benoît WitkowskiList of authors in order
- Landing page
-
https://doi.org/10.1093/jac/dkac403Publisher landing page
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https://academic.oup.com/jac/article-pdf/78/2/411/48957810/dkac403.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://academic.oup.com/jac/article-pdf/78/2/411/48957810/dkac403.pdfDirect OA link when available
- Concepts
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Mefloquine, Piperaquine, Artesunate, Artemisinin, Plasmodium falciparum, Virology, Biology, Malaria, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
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15Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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