Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysis Article Swipe
Abdullah Ashraf Hamad
,
Basma Ehab Amer
,
N. Abbas
,
Asmaa Zakria Alnajjar
,
Mostafa Meshref
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s10072-023-07119-7
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1007/s10072-023-07119-7
Objectives This systematic review and meta-analysis aimed to determine the frequency and correlates of fatigue in patients with amyotrophic lateral sclerosis (ALS). Methods Three databases were searched up to 2nd May 2023 to identify studies reporting fatigue frequency in ALS. Studies included had to identify ALS patients through one of ALS diagnostic criteria and measure fatigue by a validated tool with a specific cut-off value. Meta-analysis was conducted using RStudio's "meta" package with a random-effects model. Subgroup analyses and meta-regression explored the relationship between fatigue frequency in ALS and different covariates. Results Eleven studies, compromising 1072 patients, met the inclusion criteria and were included in our analysis. The pooled frequency of fatigue across all studies was 48% (95% CI = 40% to 57%). Our subgroup analysis based on the ALSFRS-R revealed a higher frequency of fatigue in studies with lower scores (< 30) compared to those with higher scores (≥ 30), with a pooled frequency of 62% (95% CI = 43% to 79%) and 43% (95% CI = 37% to 49%), respectively. Also, the meta-regression analysis showed a significant negative association between fatigue and ALSFRS-R mean ( P = 0.02). The included studies reported an association between fatigue and lower functional status and poorer quality of life in patients with ALS. Conclusion Our findings suggest that fatigue is prevalent in almost half of ALS patients and is associated with lower functional status and poorer quality of life, highlighting the importance of assessing and managing fatigue in ALS patients.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10072-023-07119-7
- https://link.springer.com/content/pdf/10.1007/s10072-023-07119-7.pdf
- OA Status
- hybrid
- Cited By
- 18
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387641625
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387641625Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s10072-023-07119-7Digital Object Identifier
- Title
-
Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-14Full publication date if available
- Authors
-
Abdullah Ashraf Hamad, Basma Ehab Amer, N. Abbas, Asmaa Zakria Alnajjar, Mostafa MeshrefList of authors in order
- Landing page
-
https://doi.org/10.1007/s10072-023-07119-7Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s10072-023-07119-7.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s10072-023-07119-7.pdfDirect OA link when available
- Concepts
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Meta-analysis, Amyotrophic lateral sclerosis, Medicine, Subgroup analysis, Meta-regression, Internal medicine, Neurology, Quality of life (healthcare), Random effects model, Physical therapy, Disease, Psychiatry, NursingTop concepts (fields/topics) attached by OpenAlex
- Cited by
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18Total citation count in OpenAlex
- Citations by year (recent)
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2025: 10, 2024: 8Per-year citation counts (last 5 years)
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57Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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