Prevalence and Prognostic Significance of Liver Fibrosis in Patients With Aneurysmal Subarachnoid Hemorrhage Article Swipe
Tiangui Li
,
Peng Wang
,
Xiao Gong
,
Weelic Chong
,
Yang Hai
,
Chao You
,
Juan Kang
,
Fang Fang
,
Yu Zhang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2022.850405
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2022.850405
Objectives To report the prevalence, clinical associations, and prognostic consequences of liver fibrosis in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods In a retrospective study of patients with aSAH, we evaluated three validated liver fibrosis indices and modeled them as continuous-exposure variables, including the aspartate aminotransferase/platelet ratio index (APRI), the fibrosis-4 (FIB-4) index, and the Forns index. The primary outcome was mortality at 90 days. We compared the addition of fibrosis indices to the predictors of the full Subarachnoid Hemorrhage International Trialists model. Results A total of 3,722 patients with aSAH were included in the study. According to the APRI, FIB-4 index, and Forns index, 21.7, 17.7, and 11.4% of patients had liver fibrosis. After adjusting for potential confounding factors, liver fibrosis indices were associated with increased 90-day mortality, with odds ratios of 1.35 (95% CI 1.02–1.77) for the FIB-4 index, 1.39 (95% CI.08–1.78) for APRI, and 1.53 (95% CI 1.11–2.12) for the Forns index. Similarly, high liver fibrosis indices were associated with an increased risk of rebleeding. However, the Forns index was not significantly associated with mortality and rebleeding. The addition of FIB-4 indices and APRI into the standard model improved the mortality prediction. Conclusions Liver fibrosis is common in patients with aSAH, and high liver fibrosis indices are associated with mortality and rebleeding. The addition of liver fibrosis indices to a standard clinical model significantly improves risk stratification.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2022.850405
- https://www.frontiersin.org/articles/10.3389/fneur.2022.850405/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281717886
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281717886Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fneur.2022.850405Digital Object Identifier
- Title
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Prevalence and Prognostic Significance of Liver Fibrosis in Patients With Aneurysmal Subarachnoid HemorrhageWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-02Full publication date if available
- Authors
-
Tiangui Li, Peng Wang, Xiao Gong, Weelic Chong, Yang Hai, Chao You, Juan Kang, Fang Fang, Yu ZhangList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2022.850405Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fneur.2022.850405/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fneur.2022.850405/pdfDirect OA link when available
- Concepts
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Medicine, Internal medicine, Gastroenterology, Fibrosis, Odds ratio, Confounding, Subarachnoid hemorrhageTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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