Prevalence of Agr phase variants in Staphylococcus aureus Article Swipe
Vishal Gor
,
Mitsuaki Hoshi
,
Aya J. Takemura
,
Masato Higashide
,
Veronica Medrano Romero
,
Ryosuke L. Ohniwa
,
Kazuya Morikawa
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1099/acmi.ac2020.po0002
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1099/acmi.ac2020.po0002
Staphylococcus aureus is an important human pathogen whose success is largely attributed to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the human host. The expression of these virulence factors is controlled by the quorum sensing Accessory Gene Regulator (Agr) system. However, a large proportion of clinical S. aureus isolates are consistently found to have a mutationally inactivated Agr system. These mutants have a survival advantage in the host but are considered irreversible mutants. Here we show, for the first time, that a fraction of Agr-negative mutants can revert their Agr activity. By serially passaging Agr negative strains and screening for phenotypic reversion of haemolysis and subsequent sequencing, we identified two mutational events responsible for reversion: a genetic duplication plus inversion event and a poly(A) tract alteration. Additionally, we demonstrate that one clinical Agr-negative MRSA isolate could reproducibly generate Agr-revertant colonies with a poly(A) tract genetic mechanism. We also show that these revertants activate their Agr system upon phagocytosis. To assess the significance of our findings we screened a series of primary clinical isolates, which had undergone minimal handling post-isolation, and successfully identified a fraction which were Agr phase variants. Taken together, we propose a model where some Agr-negative S. aureus strains are phase variants who can revert their Agr activity and may act as a cryptic insurance strategy against host-mediated stress.
Related Topics
Concepts
Virulence
Staphylococcus aureus
Biology
Reversion
Mutant
Quorum sensing
Gene duplication
Pathogen
Gene
Microbiology
Genetics
Staphylococcal infections
Phenotype
Human pathogen
Bacteria
Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1099/acmi.ac2020.po0002
- OA Status
- gold
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3041828055Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1099/acmi.ac2020.po0002Digital Object Identifier
- Title
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Prevalence of Agr phase variants in Staphylococcus aureusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-07-01Full publication date if available
- Authors
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Vishal Gor, Mitsuaki Hoshi, Aya J. Takemura, Masato Higashide, Veronica Medrano Romero, Ryosuke L. Ohniwa, Kazuya MorikawaList of authors in order
- Landing page
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https://doi.org/10.1099/acmi.ac2020.po0002Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1099/acmi.ac2020.po0002Direct OA link when available
- Concepts
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Virulence, Staphylococcus aureus, Biology, Reversion, Mutant, Quorum sensing, Gene duplication, Pathogen, Gene, Microbiology, Genetics, Staphylococcal infections, Phenotype, Human pathogen, BacteriaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2021: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| primary_location.is_published | True |
| primary_location.raw_source_name | Access Microbiology |
| primary_location.landing_page_url | https://doi.org/10.1099/acmi.ac2020.po0002 |
| publication_date | 2020-07-01 |
| publication_year | 2020 |
| referenced_works_count | 0 |
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