Prevalence of BCR-ABL T315I Mutation in Malaysian Patients with Imatinib-Resistant Chronic Myeloid Leukemia Article Swipe
Yuslina Mat Yusoff
,
Zahidah Abu Seman
,
Norodiyah Othman
,
Nor Rizan Kamaluddin
,
Ezalia Esa
,
Nor Zulkiply Amalina
,
Julia Abdullah
,
Zubaidah Zakaria
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.31557/apjcp.2018.19.12.3317
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.31557/apjcp.2018.19.12.3317
Objective: Chronic Myeloid Leukemia (CML) is caused by a reciprocal translocation between chromosomes 9 and 22, t(9;22) (q34;q11) which encodes for the BCR-ABL fusion protein. Discovery of Imatinib Mesylate (IM) as first line therapy has brought tremendous improvement in the management of CML. However, emergence of point mutations within the BCR-ABL gene particularly T315I mutation, affects a common BCR-ABL kinase contact residue which impairs drug binding thus contribute to treatment resistance. This study aims to investigate the BCR-ABL T315I mutation in Malaysian patients with CML. Methods: A total of 285 patients diagnosed with CML were included in this study. Mutation detection was performed using qualitative real-time PCR (qPCR). Results: Fifteen out of 285 samples (5.26%) were positive for T315I mutations after amplification with real-time PCR assay. From the total number of positive samples, six patients were in accelerated phase (AP), four in chronic phase (CP) and five in blast crisis (BC). Conclusion: Mutation testing is recommended for choosing various tyrosine kinase inhibitors (TKIs) to optimize outcomes for both cases of treatment failure or suboptimal response to imatinib. Therefore, detection of T315I mutation in CML patients are clinically useful in the selection of appropriate treatment strategies to prevent disease progression.
Related Topics
Concepts
Imatinib
Myeloid leukemia
Imatinib mesylate
Medicine
Tyrosine kinase
Mutation
Dasatinib
Fusion gene
Cancer research
Oncology
ABL
Philadelphia chromosome
Internal medicine
Chromosomal translocation
Gene
Biology
Genetics
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31557/apjcp.2018.19.12.3317
- http://journal.waocp.org/article_80040_002f76a33f14d1cd9e6d81d751beccb8.pdf
- OA Status
- gold
- Cited By
- 13
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2904360643
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2904360643Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31557/apjcp.2018.19.12.3317Digital Object Identifier
- Title
-
Prevalence of BCR-ABL T315I Mutation in Malaysian Patients with Imatinib-Resistant Chronic Myeloid LeukemiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-12-01Full publication date if available
- Authors
-
Yuslina Mat Yusoff, Zahidah Abu Seman, Norodiyah Othman, Nor Rizan Kamaluddin, Ezalia Esa, Nor Zulkiply Amalina, Julia Abdullah, Zubaidah ZakariaList of authors in order
- Landing page
-
https://doi.org/10.31557/apjcp.2018.19.12.3317Publisher landing page
- PDF URL
-
https://journal.waocp.org/article_80040_002f76a33f14d1cd9e6d81d751beccb8.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journal.waocp.org/article_80040_002f76a33f14d1cd9e6d81d751beccb8.pdfDirect OA link when available
- Concepts
-
Imatinib, Myeloid leukemia, Imatinib mesylate, Medicine, Tyrosine kinase, Mutation, Dasatinib, Fusion gene, Cancer research, Oncology, ABL, Philadelphia chromosome, Internal medicine, Chromosomal translocation, Gene, Biology, Genetics, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
13Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 4, 2021: 1, 2020: 5, 2019: 2Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Leukemia | 3 |
| abstract_inverted_index.Mesylate | 28 |
| abstract_inverted_index.Methods: | 85 |
| abstract_inverted_index.Mutation | 99, 152 |
| abstract_inverted_index.Results: | 108 |
| abstract_inverted_index.choosing | 157 |
| abstract_inverted_index.included | 95 |
| abstract_inverted_index.mutation | 79, 181 |
| abstract_inverted_index.optimize | 164 |
| abstract_inverted_index.outcomes | 165 |
| abstract_inverted_index.patients | 82, 90, 134, 184 |
| abstract_inverted_index.positive | 116, 131 |
| abstract_inverted_index.protein. | 24 |
| abstract_inverted_index.response | 174 |
| abstract_inverted_index.samples, | 132 |
| abstract_inverted_index.tyrosine | 159 |
| abstract_inverted_index.(q34;q11) | 17 |
| abstract_inverted_index.Discovery | 25 |
| abstract_inverted_index.Malaysian | 81 |
| abstract_inverted_index.detection | 100, 178 |
| abstract_inverted_index.diagnosed | 91 |
| abstract_inverted_index.emergence | 44 |
| abstract_inverted_index.imatinib. | 176 |
| abstract_inverted_index.mutation, | 54 |
| abstract_inverted_index.mutations | 47, 119 |
| abstract_inverted_index.performed | 102 |
| abstract_inverted_index.real-time | 105, 123 |
| abstract_inverted_index.selection | 190 |
| abstract_inverted_index.treatment | 69, 170, 193 |
| abstract_inverted_index.Objective: | 0 |
| abstract_inverted_index.Therefore, | 177 |
| abstract_inverted_index.clinically | 186 |
| abstract_inverted_index.contribute | 67 |
| abstract_inverted_index.inhibitors | 161 |
| abstract_inverted_index.management | 40 |
| abstract_inverted_index.reciprocal | 9 |
| abstract_inverted_index.strategies | 194 |
| abstract_inverted_index.suboptimal | 173 |
| abstract_inverted_index.tremendous | 36 |
| abstract_inverted_index.Conclusion: | 151 |
| abstract_inverted_index.accelerated | 137 |
| abstract_inverted_index.appropriate | 192 |
| abstract_inverted_index.chromosomes | 12 |
| abstract_inverted_index.improvement | 37 |
| abstract_inverted_index.investigate | 75 |
| abstract_inverted_index.qualitative | 104 |
| abstract_inverted_index.recommended | 155 |
| abstract_inverted_index.resistance. | 70 |
| abstract_inverted_index.particularly | 52 |
| abstract_inverted_index.progression. | 198 |
| abstract_inverted_index.amplification | 121 |
| abstract_inverted_index.translocation | 10 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.81218628 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |