Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New Vision Article Swipe
Kholoud A. Elkashef
,
Wafaa Emam
,
Noha M. Mesbah
,
Dina M. Abo‐Elmatty
,
Asmaa R. Abdel-Hamed
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics12041015
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics12041015
Occult hepatitis C virus infection (OCI) is the absence of HCV RNA in serum and the presence of actively replicating HCV RNA in hepatocytes and peripheral blood mononuclear cells (PBMCs), as evidenced by the presence of antigenomic negative sense single-stranded RNA. This study aimed to determine the prevalence of OCI in Egyptian lymphoma patients and assess changes in biochemical parameters in patients with confirmed OCI. The current study was conducted on 100 apparently healthy subjects as control group and 100 patients with lymphoma as a case group. HCV RNA was extracted and detected in both plasma and PBMCs using qRT-PCR. Total protein, albumin, ALT, AST, and total and direct bilirubin were measured in serum. OCI was detected in 6% of the patient group. OCI patients had lower levels of total protein and serum albumin and higher ALT and AST compared with lymphoma patients without OCI. Our study revealed that six out of 100 patients with lymphoma disorders had occult HCV infection (6%). Therefore, the possibility of this infection should be considered in patients with lymphoma.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics12041015
- https://www.mdpi.com/2075-4418/12/4/1015/pdf?version=1650254764
- OA Status
- gold
- Cited By
- 7
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224087110
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4224087110Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics12041015Digital Object Identifier
- Title
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Prevalence of Occult Hepatitis C Virus Infection in Egyptian Patients with Lymphoma: A New VisionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-17Full publication date if available
- Authors
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Kholoud A. Elkashef, Wafaa Emam, Noha M. Mesbah, Dina M. Abo‐Elmatty, Asmaa R. Abdel-HamedList of authors in order
- Landing page
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https://doi.org/10.3390/diagnostics12041015Publisher landing page
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https://www.mdpi.com/2075-4418/12/4/1015/pdf?version=1650254764Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2075-4418/12/4/1015/pdf?version=1650254764Direct OA link when available
- Concepts
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Occult, Lymphoma, Medicine, Hepatitis C virus, Peripheral blood mononuclear cell, Internal medicine, Albumin, Gastroenterology, Hepatitis C, Immunology, Hematology, Virus, Virology, Pathology, Biology, In vitro, Alternative medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 5, 2024: 1, 2022: 1Per-year citation counts (last 5 years)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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