Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion Article Swipe
Maria Elisa Amodeo
,
Annalisa Deodati
,
Stefania Pedicelli
,
Gianluca Mirra
,
Valentina Pampanini
,
Stefano Cianfarani
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1530/ec-24-0405
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1530/ec-24-0405
Graphical abstract Abstract Background A high prevalence (40–75%) of organic brain lesions in boys with central precocious puberty (CPP) has been reported. Objectives To evaluate the causes of CPP in a large cohort of males and to identify the possible predictive factors for organic brain lesions in males. Design An observational study was conducted in 102 otherwise healthy boys with CPP diagnosed from 1998 to 2023 in a single tertiary center. Methods All boys underwent a thorough clinical, endocrine and neuroimaging assessment with a detailed evaluation of the pituitary region. Results Organic CPP was found in only 8/102 children (7.8%). Children with brain tumors were younger than 8 years, had no family history positive for precocious puberty and maternal menarche occurred at an age significantly more advanced than in children with idiopathic CPP. Headache was reported at diagnosis in 7/8 children with brain tumors. A progressive increase in the occurrence of idiopathic CPP in males has been observed in the last two decades with a peak of new diagnoses during the pandemic lockdown. Conclusions Our findings indicate that the prevalence of pathological brain lesions in boys with CPP is considerably lower than previously reported, thus making the diagnosis less alarming. Age younger than 8 years, presence of neurological symptoms, family history negative for precocious puberty in the first-degree relatives and age of maternal menarche older than 11 years raise suspicion of organic CPP and should lead to prompt neuroimaging. Significance statement Differently from what has been reported in most previous studies, our study has shown a low incidence of brain tumors in male children with precocious puberty, thus making the diagnosis less alarming for parents and physicians. Some criteria for a high index of suspicion of brain tumors in boys with precocious puberty have been identified. Finally, a progressive increase in the occurrence of idiopathic CPP in boys has been observed over the past two decades with a peak of new diagnoses during the pandemic lockdown, as previously reported in girls.
Related Topics
Concepts
Medicine
Precocious puberty
Central precocious puberty
Pediatrics
Family history
Menarche
Pathological
Neuroimaging
Cohort
Internal medicine
Hormone
Psychiatry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1530/ec-24-0405
- OA Status
- gold
- Cited By
- 1
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404816703
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404816703Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1530/ec-24-0405Digital Object Identifier
- Title
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Prevalence of organic central precocious puberty in males: criteria for a high index of suspicionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
- Publication date
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2024-11-28Full publication date if available
- Authors
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Maria Elisa Amodeo, Annalisa Deodati, Stefania Pedicelli, Gianluca Mirra, Valentina Pampanini, Stefano CianfaraniList of authors in order
- Landing page
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https://doi.org/10.1530/ec-24-0405Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1530/ec-24-0405Direct OA link when available
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Medicine, Precocious puberty, Central precocious puberty, Pediatrics, Family history, Menarche, Pathological, Neuroimaging, Cohort, Internal medicine, Hormone, PsychiatryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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