Primary HIV infection features colonic damage and neutrophil inflammation yet containment of microbial translocation Article Swipe
Camilla Tincati
,
Valeria Bono
,
Elvira Stefania Cannizzo
,
Delfina Tosi
,
Federica Savi
,
Camilla Falcinella
,
Anna Casabianca
,
Chiara Orlandi
,
Carmelo Luigiano
,
Matteo Augello
,
Stefano Rusconi
,
Antonio Muscatello
,
Alessandra Bandera
,
Andrea Calcagno
,
Andrea Gori
,
Silvia Nozza
,
Giulia Marchetti
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1097/qad.0000000000003799
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1097/qad.0000000000003799
Introduction: Impairment of the gastrointestinal barrier leads to microbial translocation and peripheral immune activation, which are linked to disease progression. Data in the setting of primary HIV/SIV infection suggest that gut barrier damage is one of the first events of the pathogenic cascade, preceding mucosal immune dysfunction and microbial translocation. We assessed gut structure and immunity as well as microbial translocation in acutely and chronically-infected, combination antiretroviral therapy (cART)-naive individuals. Methods: Fifteen people with primary HIV infection (P-HIV) and 13 with chronic HIV infection (C-HIV) c-ART-naive participants were cross-sectionally studied. Gut biopsies were analysed in terms of gut reservoirs (total, integrated and unintegrated HIV DNA); tight junction proteins (E-cadherin, Zonula Occludens-1), CD4 + expression, neutrophil myeloperoxidase (histochemical staining); collagen deposition (Masson staining). Flow cytometry was used to assess γδ T-cell frequency (CD3 + panγδ+Vδ1+/Vδ2+). In plasma, we measured microbial translocation (LPS, sCD14, EndoCAb) and gut barrier function (I-FABP) markers (ELISA). Results: P-HIV displayed significantly higher tissue HIV DNA, yet neutrophil infiltration and collagen deposition in the gut were similar in the two groups. In contrast, microbial translocation markers were significantly lower in P-HIV compared with C-HIV. A trend to higher mucosal E-cadherin, and gut γδ T-cells was also observed in P-HIV. Conclusion: Early HIV infection features higher HIV DNA in the gut, yet comparable mucosal alterations to those observed in chronic infection. In contrast, microbial translocation is contained in primary HIV infection, likely because of a partial preservation of E-cadherin and mucosal immune subsets, namely γδ T-cells.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/qad.0000000000003799
- OA Status
- hybrid
- Cited By
- 4
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4389074075
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4389074075Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/qad.0000000000003799Digital Object Identifier
- Title
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Primary HIV infection features colonic damage and neutrophil inflammation yet containment of microbial translocationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-11-28Full publication date if available
- Authors
-
Camilla Tincati, Valeria Bono, Elvira Stefania Cannizzo, Delfina Tosi, Federica Savi, Camilla Falcinella, Anna Casabianca, Chiara Orlandi, Carmelo Luigiano, Matteo Augello, Stefano Rusconi, Antonio Muscatello, Alessandra Bandera, Andrea Calcagno, Andrea Gori, Silvia Nozza, Giulia MarchettiList of authors in order
- Landing page
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https://doi.org/10.1097/qad.0000000000003799Publisher landing page
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
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https://doi.org/10.1097/qad.0000000000003799Direct OA link when available
- Concepts
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Biology, Immunology, Chromosomal translocation, Immune system, Inflammation, Gut flora, Myeloperoxidase, Microbiology, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
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50Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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