Primary malignant mediastinal germ cell tumors: A single institutional experience Article Swipe
Subhasis Mishra
,
Saroj Kumar Das Majumdar
,
Mukund Sable
,
Dillip Kumar Parida
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.4103/sajc.sajc_47_19
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.4103/sajc.sajc_47_19
Bacground: Primary mediastinal malignant germ cell tumour (PMMGCT) is rare with unsatisfactory prognosis and pose difficulty in management due to lack of guidelines. Methods: All cases of PMMGCT diagnosed and treated between years 2014 to 2018 were retrospectively evaluated for clinico-pathological features, multimodality treatment and follow up. Results: Among a total of five PMMGCT cases, three were seminomatous and two were non seminomatous tumour [Yolk- sac tumour (n-1) and Mixed tumour (n-1)]. Four of these cases were non - metastatic with locally advancement and another one presented with metastasis to supraclavicular lymph node. All patients received platinum based induction chemotherapy. Post-induction chemotherapy, two cases of non seminomatous tumours underwent surgery. Among the three seminoma cases, one patient showed complete metabolic response; one with metastasis succumbed to the disease and the in-operable case of seminoma received local radiotherapy. Conclusion: PMMGCT needs a multi-disciplinary approach for appropriate diagnosis and management. Clinicopathological features like tumour site, extension, histopathological type, tumour stage and serum tumour marker are necessary for prognostication and decision making of further treatment plan.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/sajc.sajc_47_19
- OA Status
- diamond
- Cited By
- 22
- References
- 12
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2997005792
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2997005792Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/sajc.sajc_47_19Digital Object Identifier
- Title
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Primary malignant mediastinal germ cell tumors: A single institutional experienceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-12-26Full publication date if available
- Authors
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Subhasis Mishra, Saroj Kumar Das Majumdar, Mukund Sable, Dillip Kumar ParidaList of authors in order
- Landing page
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https://doi.org/10.4103/sajc.sajc_47_19Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4103/sajc.sajc_47_19Direct OA link when available
- Concepts
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Medicine, Seminoma, Chemotherapy, Pathological, Radiation therapy, Metastasis, Germ cell tumors, Stage (stratigraphy), Germ cell, Supraclavicular lymph nodes, Radiology, Surgery, Pathology, Internal medicine, Cancer, Biochemistry, Gene, Chemistry, Paleontology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2024: 3, 2023: 6, 2022: 3, 2021: 5, 2020: 5Per-year citation counts (last 5 years)
- References (count)
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12Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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