Primary Prevention of Sudden Cardiac Death in Patients with Heart Failure: How Effective is Current Pharmacologic Therapy? Article Swipe
Juán José Gavira
,
Ignacio García Bolao
,
Javier Dı́ez
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4172/2329-6607.1000198
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.4172/2329-6607.1000198
Sudden cardiac death is the most common cause of death in the early stages of heart failure.Implantable cardioverter-defibrillator therapies substantially reduce sudden cardiac death but incur morbidity and are expensive, so are recommended only after failure of optimal medical therapy.Guidelines recommend simultaneous first-line therapy with an angiotensin converting enzyme inhibitor and a beta blocker for heart failure with reduced ejection fraction, with diuretic therapy for symptom relief.The all-cause mortality benefit of angiotensin converting enzyme inhibitors (or angiotensin receptor blockers) in this setting is largely attributable to reduced deaths related to disease progression.Addition of a beta blocker improves both all-cause survival and rates of sudden cardiac death.Where symptoms persist, introduction of a mineralocorticoid receptor antagonist is recommended and can reduce sudden cardiac death.If symptoms continue, substitution of the angiotensin converting enzyme inhibitor with the angiotensin receptor neprilysin inhibitor sacubitril/valsartan significantly reduces all-cause mortality, with the benefit arising from fewer deaths from both sudden cardiac death and worsening heart failure.Further medical interventions should be instituted in specific situations as required.Disappointingly, despite evidence-led guidelines, approximately a quarter of patients who have heart failure with reduced ejection fraction do not receive standard therapy with an angiotensin converting enzyme inhibitor and beta blocker.It remains to be seen if recent guidelines for successive interventions in the event of non-response to standard therapy are more effectively adopted.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4172/2329-6607.1000198
- https://www.omicsonline.org/open-access/primary-prevention-of-sudden-cardiac-death-in-patients-with-heartfailure-how-effective-is-current-pharmacologic-therapy-2329-6607-1000198.pdf
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2531428607Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4172/2329-6607.1000198Digital Object Identifier
- Title
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Primary Prevention of Sudden Cardiac Death in Patients with Heart Failure: How Effective is Current Pharmacologic Therapy?Work title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-01Full publication date if available
- Authors
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Juán José Gavira, Ignacio García Bolao, Javier Dı́ezList of authors in order
- Landing page
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https://doi.org/10.4172/2329-6607.1000198Publisher landing page
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https://www.omicsonline.org/open-access/primary-prevention-of-sudden-cardiac-death-in-patients-with-heartfailure-how-effective-is-current-pharmacologic-therapy-2329-6607-1000198.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.omicsonline.org/open-access/primary-prevention-of-sudden-cardiac-death-in-patients-with-heartfailure-how-effective-is-current-pharmacologic-therapy-2329-6607-1000198.pdfDirect OA link when available
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Medicine, Heart failure, Primary prevention, Cardiology, Sudden cardiac death, Intensive care medicine, Internal medicine, Current (fluid), Disease, Engineering, Electrical engineeringTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2022: 1, 2016: 1Per-year citation counts (last 5 years)
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69Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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