Principal Components Analysis (PCA) of interface conservation scores and sequence alignment statistics. Article Swipe
Rasna R. Walia
,
Li C. Xue
,
Katherine Wilkins
,
Yasser EL‐Manzalawy
,
Drena Dobbs
,
Vasant Honavar
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0097725.g001
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0097725.g001
Data points in the plot correspond to the projection of a 6-dimensional vector representing the pairwise alignment of a query and homolog sequence onto a 2-dimensional space defined by the first and second principal components. Blue lines with red circles at their tips represent the axes of the original 6-dimensional space for the 6 variables used in PCA analysis: -log(E) (where is the -value), Identity Score (), Positive Score (), log(L) (where is local alignment length), alignment length fractions ( and , where and are the lengths of the query and homolog proteins, respectively). Each data point is colored according to its computed score, with higher score (red/orange) indicating higher interface conservation and lower scores (blue/green) indicating lower interface conservation. The large gray arrow indicates the direction of increasing degree of interface conservation, from Dark to Twilight to Safe Zone.
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- Type
- paratext
- Language
- en
- Landing Page
- https://figshare.com/articles/figure/_Principal_Components_Analysis_PCA_of_interface_conservation_scores_and_sequence_alignment_statistics_/1032549
- OA Status
- green
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W2255034012
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2255034012Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0097725.g001Digital Object Identifier
- Title
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Principal Components Analysis (PCA) of interface conservation scores and sequence alignment statistics.Work title
- Type
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paratextOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-12-02Full publication date if available
- Authors
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Rasna R. Walia, Li C. Xue, Katherine Wilkins, Yasser EL‐Manzalawy, Drena Dobbs, Vasant HonavarList of authors in order
- Landing page
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https://figshare.com/articles/figure/_Principal_Components_Analysis_PCA_of_interface_conservation_scores_and_sequence_alignment_statistics_/1032549Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://figshare.com/articles/figure/_Principal_Components_Analysis_PCA_of_interface_conservation_scores_and_sequence_alignment_statistics_/1032549Direct OA link when available
- Concepts
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Principal component analysis, Statistics, Sequence analysis, Computational biology, Sequence (biology), Sequence alignment, Interface (matter), Biology, Computer science, Bioinformatics, Mathematics, Genetics, Peptide sequence, Biochemistry, Pulmonary surfactant, Gibbs isotherm, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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20Other works algorithmically related by OpenAlex
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