PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS Article Swipe
Cennan Yin
,
Chenyun Wu
,
Xinyue Du
,
Yan Fang
,
Juebiao Pu
,
Jian Wu
,
Lili Tang
,
Wei Zhao
,
Yong-qiang Weng
,
Xiaokui Guo
,
Guangjie Chen
,
Zhaojun Wang
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2018.02609
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2018.02609
Although it is well-recognized that inflammation enhances leukocyte bactericidal activity, the underlying mechanisms are not clear. Here we report that PRL2 is sensitive to oxidative stress at inflamed sites. Reduced PRL2 in phagocytes causes increased respiratory burst activity and enhances phagocyte bactericidal activity. PRL2 (Phosphatase Regenerating Liver 2) is highly expressed in resting immune cells, but is markedly downregulated by inflammation. in vitro experiments showed that PRL2 was sensitive to hydrogen peroxide (H2O2), a common damage signal at inflamed sites. In response to infection, PRL2 knockout (KO) phagocytes were hyper activated, produced more reactive oxygen species (ROS) and exhibited enhanced bactericidal activity. Mice with PRL2 deficiency in the myeloid cell compartment were resistant to lethal listeria infection and cleared the bacteria more rapidly and effectively. Moreover, in vitro experiments demonstrated that PRL2 binds to GTPase Rac and regulates ROS production. Rac GTPases were more active in PRL2 (KO) phagocytes than in wild type cells after bacterium infection. Our findings indicate that PRL2 senses ROS at inflamed sites and regulates ROS production in phagocytes. This positive feedback mechanism promotes bactericidal activity of phagocytes and may play an important role in innate anti-bacterial immunity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2018.02609
- OA Status
- gold
- Cited By
- 11
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2901258674
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2901258674Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2018.02609Digital Object Identifier
- Title
-
PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROSWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-11-13Full publication date if available
- Authors
-
Cennan Yin, Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jian Wu, Lili Tang, Wei Zhao, Yong-qiang Weng, Xiaokui Guo, Guangjie Chen, Zhaojun WangList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2018.02609Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fimmu.2018.02609Direct OA link when available
- Concepts
-
Phagocyte, Reactive oxygen species, Phagocytosis, Innate immune system, Inflammation, Respiratory burst, Cell biology, Microbiology, Macrophage, Chemistry, Chronic granulomatous disease, Biology, In vitro, Immune system, Immunology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 2, 2022: 3, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2524387459, https://openalex.org/W2336656712, https://openalex.org/W2141812010, https://openalex.org/W2094908805, https://openalex.org/W2027895734, https://openalex.org/W2155679312, https://openalex.org/W1976599392, https://openalex.org/W2027446232, https://openalex.org/W2172212550, https://openalex.org/W2109897538, https://openalex.org/W1487122816, https://openalex.org/W1862488265, https://openalex.org/W2127660300, https://openalex.org/W2114827675, https://openalex.org/W2110866843, https://openalex.org/W2084141237, https://openalex.org/W2079133598, https://openalex.org/W1997023449, https://openalex.org/W2042111453, https://openalex.org/W1968960259, https://openalex.org/W2084227839, https://openalex.org/W1561726217, https://openalex.org/W2025068493, https://openalex.org/W2131917465, https://openalex.org/W2099196476, https://openalex.org/W2153672815, https://openalex.org/W2029603139, https://openalex.org/W2043986623, https://openalex.org/W4211208949 |
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| corresponding_author_ids | https://openalex.org/A5100424193, https://openalex.org/A5045394205 |
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