Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritis Article Swipe
Kiran Haresh Kumar Patel
,
Timothy Jones
,
Susanne Sattler
,
Justin C. Mason
,
Fu Siong Ng
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1152/ajpheart.00401.2020
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1152/ajpheart.00401.2020
Chronic inflammatory disorders, including rheumatoid arthritis (RA), are associated with a twofold increase in the incidence of sudden cardiac death (SCD) compared with the healthy population. Although this is partly explained by an increased prevalence of coronary artery disease, growing evidence suggests that ischemia alone cannot completely account for the increased risk. The present review explores the mechanisms of cardiac electrophysiological remodeling in response to chronic inflammation in RA. In particular, it focuses on the roles of nonischemic structural remodeling, altered cardiac ionic currents, and autonomic nervous system dysfunction in ventricular arrhythmogenesis and SCD. It also explores whether common genetic elements predispose to both RA and SCD. Finally, it evaluates the potential dual effects of disease-modifying therapy in both diminishing and promoting the risk of ventricular arrhythmias and SCD.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajpheart.00401.2020
- https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00401.2020
- OA Status
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- Cited By
- 18
- References
- 161
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W3087762178Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1152/ajpheart.00401.2020Digital Object Identifier
- Title
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Proarrhythmic electrophysiological and structural remodeling in rheumatoid arthritisWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-18Full publication date if available
- Authors
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Kiran Haresh Kumar Patel, Timothy Jones, Susanne Sattler, Justin C. Mason, Fu Siong NgList of authors in order
- Landing page
-
https://doi.org/10.1152/ajpheart.00401.2020Publisher landing page
- PDF URL
-
https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00401.2020Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00401.2020Direct OA link when available
- Concepts
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Medicine, Rheumatoid arthritis, Cardiology, Sudden cardiac death, Inflammation, Internal medicine, Coronary artery disease, Ventricular remodeling, Ischemia, Electrophysiology, Autonomic nervous system, Disease, Population, Heart failure, Heart rate, Blood pressure, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
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-
2025: 1, 2024: 1, 2023: 5, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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161Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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