Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis Article Swipe
Houari Bettahar
,
Christos Tapeinos
,
Oğulcan Işıtman
,
Carmine D’Amico
,
Alexandra Correia
,
Hélder A. Santos
,
Quan Zhou
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202507301
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/adfm.202507301
Endocytosis is vital for nutrient uptake and nanomedicine applications, but the biophysics of the pre‐internalization phase remains poorly understood at single‐cell level. This study uses advanced robotic techniques to analyze pre‐internalization adhesion mechanics. MiaPaCa‐2 cells, pancreatic cancer, displayed three interaction phases: rapid lateral displacement, a quasi‐plateau phase, and linear displacement during extraction. Adhesion time is linked to changes in cell mechanics, with MiaPaCa‐2 cells displaying a biphasic uptake process—an initial rapid adhesion phase followed by a strengthening of adhesion high variability in viscoelasticity. In contrast, fibroblasts show a gradual increase in adhesion forces, accompanied by significant rises in stiffness and viscosity. Unlike traditional endocytosis studies, this study focuses on how pathway inhibitors alter initial membrane engagement rather than uptake mechanisms. Clathrin inhibition increased adhesion by 39%, caveolae inhibition by 27%, and microtubule inhibition reduced adhesion by 48%, indicating microtubules' role in adhesion dynamics. Combined inhibition of clathrin, caveolae, and microtubules reduced adhesion by 70%, showing that disrupting multiple pathways severely impairs particle adhesion. Under repeated stress, MiaPaCa‐2 cells soften (≈75% Young's modulus reduction) due to cytoskeletal disruption, while fibroblasts gradually soften (≈71% modulus reduction), highlighting cellular adaptations. These findings provide new insights into the pre‐internalization of particles at the single‐cell level.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adfm.202507301
- OA Status
- hybrid
- References
- 98
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4410826118Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adfm.202507301Digital Object Identifier
- Title
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Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-28Full publication date if available
- Authors
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Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D’Amico, Alexandra Correia, Hélder A. Santos, Quan ZhouList of authors in order
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https://doi.org/10.1002/adfm.202507301Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/adfm.202507301Direct OA link when available
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Materials science, Particle (ecology), Particle-in-cell, Membrane, Single particle analysis, Nanotechnology, Chemical physics, Plasma, Physics, Nuclear physics, Chemistry, Aerosol, Geology, Meteorology, Oceanography, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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98Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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