Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish Article Swipe
Barbara Uszczyńska-Ratajczak
,
Sreedevi Sugunan
,
Monika Kwiatkowska
,
Maciej Migdał
,
Sílvia Carbonell Sala
,
Anna M. Sokòl
,
Cecilia Lanny Winata
,
Agnieszka Chacińska
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.22.473872
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.22.473872
Most mitochondrial proteins are encoded by nuclear genes, synthetized in the cytosol and targeted into the organelle. The import of some, but not all, nuclear-encoded mitochondrial proteins begins with translation of messenger RNAs (mRNAs) on the surface of mitochondria. To characterize the spatial organization of mitochondrial gene products in zebrafish ( Danio rerio ), we sequenced RNA from different cellular fractions. Our results confirmed the presence of nuclear-encoded mRNAs in the mitochondrial fraction, which in unperturbed conditions, are mainly transcripts encoding large proteins with specific properties, like transmembrane domains. To further explore the principles of mitochondrial protein compartmentalization in zebrafish, we quantified the transcriptomic changes for each subcellular fraction triggered by the chchd4a - / - mutation, causing the disorders in the mitochondrial protein import. Our results indicate that the proteostatic stress further restricts the population of transcripts on the mitochondrial surface, allowing only the largest and the most evolutionary conserved proteins to be synthetized there. We also show that many nuclear-encoded mitochondrial transcripts translated by the cytosolic ribosomes stay resistant to the global translation shutdown. Thus, vertebrates, in contrast to yeast, are not likely to employ localized translation to facilitate synthesis of mitochondrial proteins under proteostatic stress conditions.
Related Topics
Concepts
Biology
Zebrafish
Nuclear gene
Mitochondrion
Cell biology
Translation (biology)
Stress granule
Ribosome profiling
Gene
Mitochondrial DNA
Genetics
Messenger RNA
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.12.22.473872
- https://www.biorxiv.org/content/biorxiv/early/2021/12/23/2021.12.22.473872.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200004439
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200004439Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.12.22.473872Digital Object Identifier
- Title
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Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafishWork title
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-12-23Full publication date if available
- Authors
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Barbara Uszczyńska-Ratajczak, Sreedevi Sugunan, Monika Kwiatkowska, Maciej Migdał, Sílvia Carbonell Sala, Anna M. Sokòl, Cecilia Lanny Winata, Agnieszka ChacińskaList of authors in order
- Landing page
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https://doi.org/10.1101/2021.12.22.473872Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2021/12/23/2021.12.22.473872.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/12/23/2021.12.22.473872.full.pdfDirect OA link when available
- Concepts
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Biology, Zebrafish, Nuclear gene, Mitochondrion, Cell biology, Translation (biology), Stress granule, Ribosome profiling, Gene, Mitochondrial DNA, Genetics, Messenger RNATop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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83Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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