Profiling the interplay and coevolution of Microcystis aeruginosa and cyanosiphophage Mic1 Article Swipe
Xiaoqian Wang
,
Kang Du
,
Chaoyi Chen
,
Pu Hou
,
Weifang Li
,
Yuxing Chen
,
Qiong Li
,
Cong‐Zhao Zhou
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.00298-24
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/spectrum.00298-24
The cyanosiphophage Mic1 specifically infects the bloom-forming Microcystis aeruginosa FACHB 1339 from Lake Chaohu, China. Previous genomic analysis showed that its 92,627 bp double-stranded DNA genome consists of 98 putative open reading frames, 63% of which are of unknown function. Here, we investigated the transcriptome dynamics of Mic1 and its host using RNA sequencing. In the early, middle, and late phases of the 10 h lytic cycle, the Mic1 genes are sequentially expressed and could be further temporally grouped into two distinct clusters in each phase. Notably, six early genes, including gp49 that encodes a TnpB-like transposase, immediately reach the highest transcriptional level in half an hour, representing a pioneer cluster that rapidly regulates and redirects host metabolism toward the phage. An in-depth analysis of the host transcriptomic profile in response to Mic1 infection revealed significant upregulation of a polyketide synthase pathway and a type III-B CRISPR system, accompanied by moderate downregulation of the photosynthesis and key metabolism pathways. The constant increase of phage transcripts and relatively low replacement rate over the host transcripts indicated that Mic1 utilizes a unique strategy to gradually take over a small portion of host metabolism pathways after infection. In addition, genomic analysis of a less-infective Mic1 and a Mic1-resistant host strain further confirmed their dynamic interplay and coevolution via the frequent horizontal gene transfer. These findings provide insights into the mutual benefit and symbiosis of the highly polymorphic cyanobacteria M. aeruginosa and cyanophages. IMPORTANCE The highly polymorphic Microcystis aeruginosa is one of the predominant bloom-forming cyanobacteria in eutrophic freshwater bodies and is infected by diverse and abundant cyanophages. The presence of a large number of defense systems in M. aeruginosa genome suggests a dynamic interplay and coevolution with the cyanophages. In this study, we investigated the temporal gene expression pattern of Mic1 after infection and the corresponding transcriptional responses of its host. Moreover, the identification of a less-infective Mic1 and a Mic1-resistant host strain provided the evolved genes in the phage-host coevolution during the multiple-generation cultivation in the laboratory. Our findings enrich the knowledge on the interplay and coevolution of M. aeruginosa and its cyanophages and lay the foundation for the future application of cyanophage as a potential eco-friendly and bio-safe agent in controlling the succession of harmful cyanobacterial blooms.
Related Topics
Concepts
Biology
Transcriptome
Gene
Microcystis aeruginosa
Genetics
Lytic cycle
Microcystis
Cyanobacteria
Gene expression
Bacteria
Virus
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/spectrum.00298-24
- OA Status
- gold
- Cited By
- 4
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396580419
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396580419Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1128/spectrum.00298-24Digital Object Identifier
- Title
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Profiling the interplay and coevolution of Microcystis aeruginosa and cyanosiphophage Mic1Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-02Full publication date if available
- Authors
-
Xiaoqian Wang, Kang Du, Chaoyi Chen, Pu Hou, Weifang Li, Yuxing Chen, Qiong Li, Cong‐Zhao ZhouList of authors in order
- Landing page
-
https://doi.org/10.1128/spectrum.00298-24Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1128/spectrum.00298-24Direct OA link when available
- Concepts
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Biology, Transcriptome, Gene, Microcystis aeruginosa, Genetics, Lytic cycle, Microcystis, Cyanobacteria, Gene expression, Bacteria, VirusTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.this | 288 |
| abstract_inverted_index.type | 145 |
| abstract_inverted_index.with | 284 |
| abstract_inverted_index.FACHB | 10 |
| abstract_inverted_index.Here, | 41 |
| abstract_inverted_index.III-B | 146 |
| abstract_inverted_index.These | 221 |
| abstract_inverted_index.after | 193, 299 |
| abstract_inverted_index.agent | 368 |
| abstract_inverted_index.could | 75 |
| abstract_inverted_index.early | 89 |
| abstract_inverted_index.genes | 70, 324 |
| abstract_inverted_index.host. | 308 |
| abstract_inverted_index.hour, | 107 |
| abstract_inverted_index.large | 269 |
| abstract_inverted_index.level | 103 |
| abstract_inverted_index.lytic | 66 |
| abstract_inverted_index.phage | 164 |
| abstract_inverted_index.reach | 99 |
| abstract_inverted_index.small | 187 |
| abstract_inverted_index.their | 210 |
| abstract_inverted_index.using | 52 |
| abstract_inverted_index.which | 36 |
| abstract_inverted_index.92,627 | 22 |
| abstract_inverted_index.CRISPR | 147 |
| abstract_inverted_index.China. | 15 |
| abstract_inverted_index.bodies | 256 |
| abstract_inverted_index.cycle, | 67 |
| abstract_inverted_index.during | 329 |
| abstract_inverted_index.early, | 57 |
| abstract_inverted_index.enrich | 338 |
| abstract_inverted_index.future | 358 |
| abstract_inverted_index.genes, | 90 |
| abstract_inverted_index.genome | 26, 277 |
| abstract_inverted_index.highly | 233, 242 |
| abstract_inverted_index.mutual | 227 |
| abstract_inverted_index.number | 270 |
| abstract_inverted_index.phage. | 121 |
| abstract_inverted_index.phase. | 86 |
| abstract_inverted_index.phases | 61 |
| abstract_inverted_index.showed | 19 |
| abstract_inverted_index.strain | 207, 320 |
| abstract_inverted_index.study, | 289 |
| abstract_inverted_index.toward | 119 |
| abstract_inverted_index.unique | 180 |
| abstract_inverted_index.Chaohu, | 14 |
| abstract_inverted_index.benefit | 228 |
| abstract_inverted_index.blooms. | 376 |
| abstract_inverted_index.cluster | 111 |
| abstract_inverted_index.defense | 272 |
| abstract_inverted_index.diverse | 261 |
| abstract_inverted_index.dynamic | 211, 280 |
| abstract_inverted_index.encodes | 94 |
| abstract_inverted_index.evolved | 323 |
| abstract_inverted_index.frames, | 33 |
| abstract_inverted_index.further | 77, 208 |
| abstract_inverted_index.genomic | 17, 197 |
| abstract_inverted_index.grouped | 79 |
| abstract_inverted_index.harmful | 374 |
| abstract_inverted_index.highest | 101 |
| abstract_inverted_index.infects | 5 |
| abstract_inverted_index.middle, | 58 |
| abstract_inverted_index.pathway | 142 |
| abstract_inverted_index.pattern | 296 |
| abstract_inverted_index.pioneer | 110 |
| abstract_inverted_index.portion | 188 |
| abstract_inverted_index.profile | 129 |
| abstract_inverted_index.provide | 223 |
| abstract_inverted_index.rapidly | 113 |
| abstract_inverted_index.reading | 32 |
| abstract_inverted_index.system, | 148 |
| abstract_inverted_index.systems | 273 |
| abstract_inverted_index.unknown | 39 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Notably, | 87 |
| abstract_inverted_index.Previous | 16 |
| abstract_inverted_index.abundant | 263 |
| abstract_inverted_index.analysis | 18, 124, 198 |
| abstract_inverted_index.bio-safe | 367 |
| abstract_inverted_index.clusters | 83 |
| abstract_inverted_index.consists | 27 |
| abstract_inverted_index.constant | 161 |
| abstract_inverted_index.distinct | 82 |
| abstract_inverted_index.dynamics | 46 |
| abstract_inverted_index.findings | 222, 337 |
| abstract_inverted_index.frequent | 217 |
| abstract_inverted_index.in-depth | 123 |
| abstract_inverted_index.increase | 162 |
| abstract_inverted_index.infected | 259 |
| abstract_inverted_index.insights | 224 |
| abstract_inverted_index.moderate | 151 |
| abstract_inverted_index.pathways | 192 |
| abstract_inverted_index.presence | 266 |
| abstract_inverted_index.provided | 321 |
| abstract_inverted_index.putative | 30 |
| abstract_inverted_index.response | 131 |
| abstract_inverted_index.revealed | 135 |
| abstract_inverted_index.strategy | 181 |
| abstract_inverted_index.suggests | 278 |
| abstract_inverted_index.synthase | 141 |
| abstract_inverted_index.temporal | 293 |
| abstract_inverted_index.utilizes | 178 |
| abstract_inverted_index.Moreover, | 309 |
| abstract_inverted_index.TnpB-like | 96 |
| abstract_inverted_index.addition, | 196 |
| abstract_inverted_index.confirmed | 209 |
| abstract_inverted_index.eutrophic | 254 |
| abstract_inverted_index.expressed | 73 |
| abstract_inverted_index.function. | 40 |
| abstract_inverted_index.gradually | 183 |
| abstract_inverted_index.including | 91 |
| abstract_inverted_index.indicated | 175 |
| abstract_inverted_index.infection | 134, 300 |
| abstract_inverted_index.interplay | 212, 281, 343 |
| abstract_inverted_index.knowledge | 340 |
| abstract_inverted_index.pathways. | 159 |
| abstract_inverted_index.potential | 364 |
| abstract_inverted_index.redirects | 116 |
| abstract_inverted_index.regulates | 114 |
| abstract_inverted_index.responses | 305 |
| abstract_inverted_index.symbiosis | 230 |
| abstract_inverted_index.transfer. | 220 |
| abstract_inverted_index.IMPORTANCE | 240 |
| abstract_inverted_index.aeruginosa | 9, 237, 245, 276, 348 |
| abstract_inverted_index.cyanophage | 361 |
| abstract_inverted_index.expression | 295 |
| abstract_inverted_index.foundation | 355 |
| abstract_inverted_index.freshwater | 255 |
| abstract_inverted_index.horizontal | 218 |
| abstract_inverted_index.infection. | 194 |
| abstract_inverted_index.metabolism | 118, 158, 191 |
| abstract_inverted_index.phage-host | 327 |
| abstract_inverted_index.polyketide | 140 |
| abstract_inverted_index.relatively | 167 |
| abstract_inverted_index.succession | 372 |
| abstract_inverted_index.temporally | 78 |
| abstract_inverted_index.Microcystis | 8, 244 |
| abstract_inverted_index.accompanied | 149 |
| abstract_inverted_index.application | 359 |
| abstract_inverted_index.coevolution | 214, 283, 328, 345 |
| abstract_inverted_index.controlling | 370 |
| abstract_inverted_index.cultivation | 332 |
| abstract_inverted_index.cyanophages | 351 |
| abstract_inverted_index.immediately | 98 |
| abstract_inverted_index.laboratory. | 335 |
| abstract_inverted_index.polymorphic | 234, 243 |
| abstract_inverted_index.predominant | 250 |
| abstract_inverted_index.replacement | 169 |
| abstract_inverted_index.sequencing. | 54 |
| abstract_inverted_index.significant | 136 |
| abstract_inverted_index.transcripts | 165, 174 |
| abstract_inverted_index.cyanophages. | 239, 264, 286 |
| abstract_inverted_index.eco-friendly | 365 |
| abstract_inverted_index.investigated | 43, 291 |
| abstract_inverted_index.representing | 108 |
| abstract_inverted_index.sequentially | 72 |
| abstract_inverted_index.specifically | 4 |
| abstract_inverted_index.transposase, | 97 |
| abstract_inverted_index.upregulation | 137 |
| abstract_inverted_index.bloom-forming | 7, 251 |
| abstract_inverted_index.corresponding | 303 |
| abstract_inverted_index.cyanobacteria | 235, 252 |
| abstract_inverted_index.transcriptome | 45 |
| abstract_inverted_index.Mic1-resistant | 205, 318 |
| abstract_inverted_index.cyanobacterial | 375 |
| abstract_inverted_index.downregulation | 152 |
| abstract_inverted_index.identification | 311 |
| abstract_inverted_index.less-infective | 201, 314 |
| abstract_inverted_index.photosynthesis | 155 |
| abstract_inverted_index.transcriptomic | 128 |
| abstract_inverted_index.cyanosiphophage | 2 |
| abstract_inverted_index.double-stranded | 24 |
| abstract_inverted_index.transcriptional | 102, 304 |
| abstract_inverted_index.multiple-generation | 331 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| citation_normalized_percentile.value | 0.87053951 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |