Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma Article Swipe
Mariya Muzyka
,
Silvia Ottaviani
,
Irene Caffa
,
Tommaso Bonfiglio
,
Erica Parisi
,
Ana Guijarro
,
Luca Tagliafico
,
Roberto M. Lemoli
,
Marta Ponzano
,
Cristina Marelli
,
Alessio Signori
,
Alessio Nencioni
,
Michele Cea
,
Fiammetta Monacelli
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.15.24312039
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.15.24312039
Introduction Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its assessment, remains to be firmly established. Materials and Methods This retrospective observational study investigated 36 patients, aged 65 or older, who underwent Comprehensive Geriatric Assessment (CGA). The average patient age was 76 (SD 6.22), with 33.3% being female. Patients were evaluated using the International Myeloma Working Group Frailty Index (IMWG-FI) and the 40-item Rockwood’s Frailty Index (FI) at the Oncogeriatrics clinic of the IRCCS Polyclinic San Martino Hospital, Genoa, Italy, between December 2017 and August 2021. Laboratory, cancer-specific, demographic, and clinical variables were collected. Survival analysis and frailty comparison were conducted using Stata version 17.0. Results Stepwise multivariate analysis identified Numerical Rating Scale (NRS) (HR 1.40, 95% CI 1.09-1.78, p=0.008) and Rockwood’s Frailty Index (FI) (HR 2.23, 95% CI 1.29-3.87, p=0.004) as significant prognostic predictors, adjusted for sex, ISS stage, and multimorbility. Comparison between Rockwood’s FI and IMWG-FI using Spearman correlation coefficient showed no statistically significant correlation (r=0.268, p=0.114). Multivariate Cox model, adjusting for sex, International Staging System (ISS) stage, and Cumulative Illness Rating Scale (CIRS) comorbidity index, demonstrated the superior predictive ability of Rockwood’s FI over IMWG-FI (C-index 0.775 vs 0.749). Discussion the 40-item Rockwood FI emerges as a valuable tool for prognostication in old MM patients, surpassing the traditional IMWG-FI in predictive accuracy, emphasizing the importance of a comprehensive approach considering both disease-specific and patient-related factors.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.15.24312039
- https://www.medrxiv.org/content/medrxiv/early/2024/08/20/2024.08.15.24312039.full.pdf
- OA Status
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- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401834468
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https://openalex.org/W4401834468Canonical identifier for this work in OpenAlex
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- Title
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Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myelomaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-20Full publication date if available
- Authors
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Mariya Muzyka, Silvia Ottaviani, Irene Caffa, Tommaso Bonfiglio, Erica Parisi, Ana Guijarro, Luca Tagliafico, Roberto M. Lemoli, Marta Ponzano, Cristina Marelli, Alessio Signori, Alessio Nencioni, Michele Cea, Fiammetta MonacelliList of authors in order
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https://doi.org/10.1101/2024.08.15.24312039Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2024/08/20/2024.08.15.24312039.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2024/08/20/2024.08.15.24312039.full.pdfDirect OA link when available
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Multiple myeloma, Medicine, Term (time), Gerontology, Intensive care medicine, Internal medicine, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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